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- W2088017871 abstract "Trehalase, an anomer-inverting glycosidase, hydrolyzes only α,α-trehalose in natural substrates to release equimolecular β-glucose and α-glucose. Since the hydrolytic reaction is reversible, α,α-[1,1′-2H]trehalose is capable of synthesis from [1-2H]glucose through the reverse reaction of trehalase. α-Secondary deuterium kinetic isotope effects (α-SDKIEs) for the hydrolysis of synthesized α,α-[1,1′-2H]trehalose by honeybee trehalase were measured to examine the catalytic reaction mechanism. Relatively high k H⁄k D value of 1.53 for α-SDKIEs was observed. The data imply that the catalytic reaction of the trehalase occurs by the oxocarbenium ion intermediate mechanism. In addition, the hydrolytic reaction of glycosidase is discussed from the viewpoint of chemical reactivity for the hydrolysis of acetal in organic chemistry. As to the hydrolytic reaction mechanism of glycosidases, oxocarbenium ion intermediate and nucleophilic displacement mechanisms have been widely recognized, but it is pointed out for the first time that the former mechanism is rational and valid and generally the latter mechanism is unlikely to occur in the hydrolytic reaction of glycosidases." @default.
- W2088017871 created "2016-06-24" @default.
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- W2088017871 date "2009-11-23" @default.
- W2088017871 modified "2023-09-27" @default.
- W2088017871 title "Catalytic Reaction Mechanism Based on α-Secondary Deuterium Isotope Effects in Hydrolysis of Trehalose by European Honeybee Trehalase" @default.
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- W2088017871 doi "https://doi.org/10.1271/bbb.90447" @default.
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