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• W2088022718 abstract "To examine and compare the efficacy and safety of salmeterol xinafoate, a long-acting inhaled beta2-adrenergic agonist, with inhaled ipratropium bromide and inhaled placebo in patients with COPD.A stratified, randomized, double-blind, double-dummy, placebo-controlled, parallel group clinical trial.Multiple sites at clinics and university medical centers throughout the United States.Four hundred eleven symptomatic patients with COPD with FEV1 < or = 65% predicted and no clinically significant concurrent disease.Comparison of inhaled salmeterol (42 microg twice daily), inhaled ipratropium bromide (36 microg four times a day), and inhaled placebo (2 puffs four times a day) over 12 weeks.Salmeterol xinafoate was significantly (p < 0.0001) better than placebo and ipratropium in improving lung function at the recommended doses over the 12-week trial. Both salmeterol and ipratropium reduced dyspnea related to activities of daily living compared with placebo; this improvement was associated with reduced use of supplemental albuterol. Analyses of time to first COPD exacerbation revealed salmeterol to be superior to placebo and ipratropium (p < 0.05). Adverse effects were similar among the three treatments.These collective data support the use of salmeterol as first-line bronchodilator therapy for the long-term treatment of airflow obstruction in patients with COPD." @default.
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• W2088022718 date "1999-04-01" @default.
• W2088022718 modified "2023-09-27" @default.
• W2088022718 title "Efficacy of Salmeterol Xinafoate in the Treatment of COPD" @default.
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• W2088022718 doi "https://doi.org/10.1378/chest.115.4.957" @default.
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