Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088036511> ?p ?o ?g. }
- W2088036511 abstract "A series of polyhalo 2-aryl-4-aminoquinazolines 3a–3n were prepared by reacting polyhalo isophthalonitriles 1a–1c with amidine hydrochlorides under basic conditions with good yields (70–93%). Also, through the reaction of polyhalo isophthalonitriles 1a–1c with hydrazines to give novel polyhalo 3-aminoindazoles 5 and 7 with moderate yield (70–87%). The anticancer activities of compounds 3, 5 and 7 were evaluated in vitro against human cell lines SKOV-3, HeLa, U2-OS, A549, and MCF-7. Some compounds showed excellent growth inhibitory activities and 3a was found to be the most potent derivative, with an IC50 value lower than 3.86 μg mL−1 against the five tumor cell lines. The mechanism of action of representative compound 5b was investigated in the HCT116 colorectal cancer cell line. It was shown that 5b reduced cell viability of cancer cells in a time and concentration dependent manner. Cells treated with 5b accumulate in the G2/M phase of the cell cycle and finally go into apoptosis." @default.
- W2088036511 created "2016-06-24" @default.
- W2088036511 creator A5019139936 @default.
- W2088036511 creator A5039381424 @default.
- W2088036511 creator A5046349754 @default.
- W2088036511 creator A5062354424 @default.
- W2088036511 creator A5069190322 @default.
- W2088036511 creator A5081210233 @default.
- W2088036511 date "2013-01-01" @default.
- W2088036511 modified "2023-09-25" @default.
- W2088036511 title "Synthesis of polyhalo 2-aryl-4-aminoquinazolines and 3-amino-indazoles as anti-cancer agents" @default.
- W2088036511 cites W1506642042 @default.
- W2088036511 cites W1963497200 @default.
- W2088036511 cites W1971681882 @default.
- W2088036511 cites W1974771624 @default.
- W2088036511 cites W1976117602 @default.
- W2088036511 cites W1990057742 @default.
- W2088036511 cites W1991864810 @default.
- W2088036511 cites W1996764617 @default.
- W2088036511 cites W2004341508 @default.
- W2088036511 cites W2005738368 @default.
- W2088036511 cites W2006332469 @default.
- W2088036511 cites W2010514019 @default.
- W2088036511 cites W2011181574 @default.
- W2088036511 cites W2017165414 @default.
- W2088036511 cites W2017544644 @default.
- W2088036511 cites W2026084014 @default.
- W2088036511 cites W2032048844 @default.
- W2088036511 cites W2033377350 @default.
- W2088036511 cites W2041797943 @default.
- W2088036511 cites W2048641541 @default.
- W2088036511 cites W2053954227 @default.
- W2088036511 cites W2067985580 @default.
- W2088036511 cites W2081022845 @default.
- W2088036511 cites W2083284090 @default.
- W2088036511 cites W2087824460 @default.
- W2088036511 cites W2089330303 @default.
- W2088036511 cites W2091010250 @default.
- W2088036511 cites W2099111782 @default.
- W2088036511 cites W2102438936 @default.
- W2088036511 cites W2140927361 @default.
- W2088036511 cites W2155769896 @default.
- W2088036511 cites W2165994428 @default.
- W2088036511 cites W2333073466 @default.
- W2088036511 cites W2950369396 @default.
- W2088036511 cites W2950675362 @default.
- W2088036511 cites W2950731649 @default.
- W2088036511 cites W2953178902 @default.
- W2088036511 doi "https://doi.org/10.1039/c3ra23059g" @default.
- W2088036511 hasPublicationYear "2013" @default.
- W2088036511 type Work @default.
- W2088036511 sameAs 2088036511 @default.
- W2088036511 citedByCount "3" @default.
- W2088036511 countsByYear W20880365112015 @default.
- W2088036511 countsByYear W20880365112018 @default.
- W2088036511 countsByYear W20880365112019 @default.
- W2088036511 crossrefType "journal-article" @default.
- W2088036511 hasAuthorship W2088036511A5019139936 @default.
- W2088036511 hasAuthorship W2088036511A5039381424 @default.
- W2088036511 hasAuthorship W2088036511A5046349754 @default.
- W2088036511 hasAuthorship W2088036511A5062354424 @default.
- W2088036511 hasAuthorship W2088036511A5069190322 @default.
- W2088036511 hasAuthorship W2088036511A5081210233 @default.
- W2088036511 hasConcept C121608353 @default.
- W2088036511 hasConcept C178790620 @default.
- W2088036511 hasConcept C185592680 @default.
- W2088036511 hasConcept C190283241 @default.
- W2088036511 hasConcept C202751555 @default.
- W2088036511 hasConcept C21951064 @default.
- W2088036511 hasConcept C2777366897 @default.
- W2088036511 hasConcept C2777752497 @default.
- W2088036511 hasConcept C2778622868 @default.
- W2088036511 hasConcept C2780263894 @default.
- W2088036511 hasConcept C2781076698 @default.
- W2088036511 hasConcept C29537977 @default.
- W2088036511 hasConcept C54355233 @default.
- W2088036511 hasConcept C55493867 @default.
- W2088036511 hasConcept C71240020 @default.
- W2088036511 hasConcept C81729549 @default.
- W2088036511 hasConcept C81885089 @default.
- W2088036511 hasConcept C86803240 @default.
- W2088036511 hasConcept C96232424 @default.
- W2088036511 hasConceptScore W2088036511C121608353 @default.
- W2088036511 hasConceptScore W2088036511C178790620 @default.
- W2088036511 hasConceptScore W2088036511C185592680 @default.
- W2088036511 hasConceptScore W2088036511C190283241 @default.
- W2088036511 hasConceptScore W2088036511C202751555 @default.
- W2088036511 hasConceptScore W2088036511C21951064 @default.
- W2088036511 hasConceptScore W2088036511C2777366897 @default.
- W2088036511 hasConceptScore W2088036511C2777752497 @default.
- W2088036511 hasConceptScore W2088036511C2778622868 @default.
- W2088036511 hasConceptScore W2088036511C2780263894 @default.
- W2088036511 hasConceptScore W2088036511C2781076698 @default.
- W2088036511 hasConceptScore W2088036511C29537977 @default.
- W2088036511 hasConceptScore W2088036511C54355233 @default.
- W2088036511 hasConceptScore W2088036511C55493867 @default.
- W2088036511 hasConceptScore W2088036511C71240020 @default.
- W2088036511 hasConceptScore W2088036511C81729549 @default.
- W2088036511 hasConceptScore W2088036511C81885089 @default.
- W2088036511 hasConceptScore W2088036511C86803240 @default.