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- W2088045315 abstract "Routinely processed paraffin sections from 20 patients with adult laryngeal papillomas were examined for the presence of human papillomavirus type 11 (HPV-11) DNA and its specific mRNA by in situ hybridization methods using 35S-labeled RNA probes. Immunohistochemical techniques were also used to identify papillomavirus genus-specific common antigen (pgsantigen). HPV-11 DNA signals and/or papillomavirus genus-specific common antigen were detected in all eight samples of multiple laryngeal papilloma. On the other hand, in 12 samples of single laryngeal papilloma, neither papillomavirus genus-specific common antigen nor HPV-11 DNA were detected. Four patients were positive for both HPV-11 DNA and pgs-antigen. In three of these four patients, HPV-11 mRNA signals were also detected. These results provided direct evidence of the association of HPV and adult multiple laryngeal papilloma." @default.
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- W2088045315 date "1989-01-01" @default.
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- W2088045315 title "In Situ Hybridization and Xmmunohistochemical Study of Human Papillomavirus Infection in Adult Laryngeal Papillomas" @default.
- W2088045315 doi "https://doi.org/10.1288/00005537-198901000-00015" @default.
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