FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088045407> ?p ?o ?g. }

• W2088045407 endingPage "F302" @default.
• W2088045407 startingPage "F287" @default.
• W2088045407 abstract "In rabbit proximal tubular cells, ANG II type 2-receptor (AT 2 )-induced arachidonic acid release is PLA 2 coupled and dependent of G protein βγ (Gβγ) subunits. Moreover, ANG II activates ERK1/2 and transactivates EGFR via a c-Src-dependent mechanism. Arachidonic acid has been shown to mimic this effect, at least in part, by an undetermined mechanism. In this study, we determined the effects of ANG II on fibronectin expression in cultured rabbit proximal tubule cells and elucidated the signaling pathways associated with such expression. We found that ANG II and transfection of Gβγ subunits directly increased fibronectin protein expression, and this increase was inhibited by overexpression of β-adrenergic receptor kinase (βARK)-ct or DN-Src. Moreover, ANG II-induced fibronectin protein expression was significantly abrogated by the AT 2 receptor antagonist PD123319. In addition, inhibition of cystolic PLA 2 diminished ANG II-induced fibronectin expression. Endogenous arachidonic acid mimicked ANG II-induced fibronectin expression. We also found that overexpression of Gβγ subunits induced c-Src, ERK1/2, and EGFR tyrosine phosphorylation, which can be inhibited by overexpression of βARK-ct or DN-Src. Gβγ also induced c-Src SH2 domain association with the EGFR. Supporting these findings, in rabbit proximal tubular epithelium, immunoblot analysis indicated that βγ expression was significant. Interestingly, arachidonic acid- and eicosatetraenoic acid-induced responses were preserved in the presence of βARK-ct. This is the first report demonstrating the regulation of EGFR, ERK1/2, c-Src, and fibronectin by Gβγ subunits in renal epithelial cells. Moreover, this work demonstrates a role for Gβγ heterotrimeric proteins in ANG II, but not arachidonic acid, signaling in renal epithelial cells." @default.
• W2088045407 created "2016-06-24" @default.
• W2088045407 creator A5020566352 @default.
• W2088045407 creator A5032169782 @default.
• W2088045407 creator A5053159837 @default.
• W2088045407 creator A5063160667 @default.
• W2088045407 date "2014-08-01" @default.
• W2088045407 modified "2023-09-27" @default.
• W2088045407 title "Angiotensin II stimulates fibronectin protein synthesis via a Gβγ/arachidonic acid-dependent pathway" @default.
• W2088045407 cites W1523962342 @default.
• W2088045407 cites W1546091073 @default.
• W2088045407 cites W1563716772 @default.
• W2088045407 cites W1576334466 @default.
• W2088045407 cites W1591510379 @default.
• W2088045407 cites W1593556921 @default.
• W2088045407 cites W1604214492 @default.
• W2088045407 cites W1663047717 @default.
• W2088045407 cites W1967352670 @default.
• W2088045407 cites W1975936792 @default.
• W2088045407 cites W1976231373 @default.
• W2088045407 cites W1978410319 @default.
• W2088045407 cites W1978799672 @default.
• W2088045407 cites W1981493299 @default.
• W2088045407 cites W1984261234 @default.
• W2088045407 cites W1990839004 @default.
• W2088045407 cites W1991475526 @default.
• W2088045407 cites W1997266959 @default.
• W2088045407 cites W1997995239 @default.
• W2088045407 cites W2003343079 @default.
• W2088045407 cites W2006985579 @default.
• W2088045407 cites W2008812258 @default.
• W2088045407 cites W2017295712 @default.
• W2088045407 cites W2028615837 @default.
• W2088045407 cites W2034460243 @default.
• W2088045407 cites W2040098150 @default.
• W2088045407 cites W2042154282 @default.
• W2088045407 cites W2044788190 @default.
• W2088045407 cites W2050820350 @default.
• W2088045407 cites W2053223614 @default.
• W2088045407 cites W2058376450 @default.
• W2088045407 cites W2082817039 @default.
• W2088045407 cites W2087511582 @default.
• W2088045407 cites W2095189692 @default.
• W2088045407 cites W2095546290 @default.
• W2088045407 cites W2097665925 @default.
• W2088045407 cites W2101413460 @default.
• W2088045407 cites W2123190981 @default.
• W2088045407 cites W2125093361 @default.
• W2088045407 cites W2128716954 @default.
• W2088045407 cites W2129250322 @default.
• W2088045407 cites W2131340343 @default.
• W2088045407 cites W2137896531 @default.
• W2088045407 cites W2146164021 @default.
• W2088045407 cites W2153899018 @default.
• W2088045407 cites W2157427328 @default.
• W2088045407 cites W2169316199 @default.
• W2088045407 cites W2335620420 @default.
• W2088045407 cites W2398132406 @default.
• W2088045407 cites W4320578728 @default.
• W2088045407 doi "https://doi.org/10.1152/ajprenal.00094.2014" @default.
• W2088045407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4121571" @default.
• W2088045407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24920755" @default.
• W2088045407 hasPublicationYear "2014" @default.
• W2088045407 type Work @default.
• W2088045407 sameAs 2088045407 @default.
• W2088045407 citedByCount "8" @default.
• W2088045407 countsByYear W20880454072015 @default.
• W2088045407 countsByYear W20880454072018 @default.
• W2088045407 countsByYear W20880454072019 @default.
• W2088045407 countsByYear W20880454072020 @default.
• W2088045407 countsByYear W20880454072022 @default.
• W2088045407 countsByYear W20880454072023 @default.
• W2088045407 crossrefType "journal-article" @default.
• W2088045407 hasAuthorship W2088045407A5020566352 @default.
• W2088045407 hasAuthorship W2088045407A5032169782 @default.
• W2088045407 hasAuthorship W2088045407A5053159837 @default.
• W2088045407 hasAuthorship W2088045407A5063160667 @default.
• W2088045407 hasBestOaLocation W20880454072 @default.
• W2088045407 hasConcept C108636557 @default.
• W2088045407 hasConcept C11960822 @default.
• W2088045407 hasConcept C134018914 @default.
• W2088045407 hasConcept C153911025 @default.
• W2088045407 hasConcept C170493617 @default.
• W2088045407 hasConcept C181199279 @default.
• W2088045407 hasConcept C185592680 @default.
• W2088045407 hasConcept C189165786 @default.
• W2088045407 hasConcept C2778078955 @default.
• W2088045407 hasConcept C2908929049 @default.
• W2088045407 hasConcept C42362537 @default.
• W2088045407 hasConcept C55493867 @default.
• W2088045407 hasConcept C62478195 @default.
• W2088045407 hasConcept C86492073 @default.
• W2088045407 hasConcept C86803240 @default.
• W2088045407 hasConcept C95444343 @default.
• W2088045407 hasConceptScore W2088045407C108636557 @default.
• W2088045407 hasConceptScore W2088045407C11960822 @default.
• W2088045407 hasConceptScore W2088045407C134018914 @default.
• W2088045407 hasConceptScore W2088045407C153911025 @default.

• next