FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088045602> ?p ?o ?g. }

• W2088045602 endingPage "194" @default.
• W2088045602 startingPage "190" @default.
• W2088045602 abstract "To investigate the expression of endothelin-1 (ET-1) and adrenomedullin (ADM) in the renal pelvis, stenotic ureteropelvic junction, and ureter of 20 male Wistar rats with congenital unilateral ureteropelvic junction obstruction; the normal contralateral kidneys served as controls. The molecular pathophysiology of congenital ureteropelvic junction obstruction is still unclear. The implication of altered peptidergic innervation is under discussion. Our study group has recently been able to demonstrate a significant increase in ET-1 and a significant decrease in ADM in prestenotic and stenotic tissue, but not in the remainder of the ureter, compared with controls.Twenty animals were killed, and samples of the renal pelvis, ureteropelvic junction, upper ureter, middle part of the ureter, and lower ureter were immediately snap-frozen and stored in liquid nitrogen. Total RNA was extracted, and subsequently 1 microg of RNA was reversely transcribed. mRNA expression of ET-1 and ADM was determined semiquantitatively using on-line polymerase chain reaction. The expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was determined to relate the specific mRNA expression to the expression of a housekeeping gene.We found a significant increase in the expression of ET-1 in the obstructed junctions related to GAPDH (P <0.001). The expression of ADM, however, revealed no statistically significant differences. No differences at all could be detected in the tissue samples from the rest of the ureter.Alterations in the local production of peptidergic neurotransmitters, especially ET-1, may contribute to the molecular pathogenesis of ureteropelvic junction obstruction. Results previously obtained in the stenotic tissue from children were confirmed in the stenotic tissue from the rat model. We hypothesize that the alterations are disease-, but not age-specific." @default.
• W2088045602 created "2016-06-24" @default.
• W2088045602 creator A5006966089 @default.
• W2088045602 creator A5017333758 @default.
• W2088045602 creator A5019770940 @default.
• W2088045602 creator A5040102378 @default.
• W2088045602 creator A5070999622 @default.
• W2088045602 creator A5088519516 @default.
• W2088045602 creator A5090514831 @default.
• W2088045602 date "2004-01-01" @default.
• W2088045602 modified "2023-09-24" @default.
• W2088045602 title "Congenital unilateral ureteropelvic junction obstruction of the rat: a useful animal model for human ureteropelvic junction obstruction?" @default.
• W2088045602 cites W1574811330 @default.
• W2088045602 cites W166547845 @default.
• W2088045602 cites W1964479164 @default.
• W2088045602 cites W1973929461 @default.
• W2088045602 cites W1991522691 @default.
• W2088045602 cites W1994091239 @default.
• W2088045602 cites W1998175274 @default.
• W2088045602 cites W2003378872 @default.
• W2088045602 cites W2003671607 @default.
• W2088045602 cites W2008639630 @default.
• W2088045602 cites W2015896729 @default.
• W2088045602 cites W2018505804 @default.
• W2088045602 cites W2018761569 @default.
• W2088045602 cites W2018958299 @default.
• W2088045602 cites W2038614737 @default.
• W2088045602 cites W2092419989 @default.
• W2088045602 cites W2135500293 @default.
• W2088045602 cites W2162664545 @default.
• W2088045602 cites W2163341842 @default.
• W2088045602 cites W2164578725 @default.
• W2088045602 cites W2277327479 @default.
• W2088045602 cites W2410002992 @default.
• W2088045602 cites W2410065247 @default.
• W2088045602 cites W2418842690 @default.
• W2088045602 cites W4292340830 @default.
• W2088045602 cites W4294731714 @default.
• W2088045602 doi "https://doi.org/10.1016/j.urology.2003.07.019" @default.
• W2088045602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14751390" @default.
• W2088045602 hasPublicationYear "2004" @default.
• W2088045602 type Work @default.
• W2088045602 sameAs 2088045602 @default.
• W2088045602 citedByCount "12" @default.
• W2088045602 countsByYear W20880456022012 @default.
• W2088045602 countsByYear W20880456022014 @default.
• W2088045602 countsByYear W20880456022016 @default.
• W2088045602 crossrefType "journal-article" @default.
• W2088045602 hasAuthorship W2088045602A5006966089 @default.
• W2088045602 hasAuthorship W2088045602A5017333758 @default.
• W2088045602 hasAuthorship W2088045602A5019770940 @default.
• W2088045602 hasAuthorship W2088045602A5040102378 @default.
• W2088045602 hasAuthorship W2088045602A5070999622 @default.
• W2088045602 hasAuthorship W2088045602A5088519516 @default.
• W2088045602 hasAuthorship W2088045602A5090514831 @default.
• W2088045602 hasConcept C10162356 @default.
• W2088045602 hasConcept C104317684 @default.
• W2088045602 hasConcept C105702510 @default.
• W2088045602 hasConcept C126322002 @default.
• W2088045602 hasConcept C126894567 @default.
• W2088045602 hasConcept C134018914 @default.
• W2088045602 hasConcept C134792803 @default.
• W2088045602 hasConcept C142724271 @default.
• W2088045602 hasConcept C150194340 @default.
• W2088045602 hasConcept C2776664737 @default.
• W2088045602 hasConcept C2777521186 @default.
• W2088045602 hasConcept C2779863012 @default.
• W2088045602 hasConcept C2780091579 @default.
• W2088045602 hasConcept C2781040948 @default.
• W2088045602 hasConcept C55493867 @default.
• W2088045602 hasConcept C71924100 @default.
• W2088045602 hasConcept C77411442 @default.
• W2088045602 hasConcept C86803240 @default.
• W2088045602 hasConceptScore W2088045602C10162356 @default.
• W2088045602 hasConceptScore W2088045602C104317684 @default.
• W2088045602 hasConceptScore W2088045602C105702510 @default.
• W2088045602 hasConceptScore W2088045602C126322002 @default.
• W2088045602 hasConceptScore W2088045602C126894567 @default.
• W2088045602 hasConceptScore W2088045602C134018914 @default.
• W2088045602 hasConceptScore W2088045602C134792803 @default.
• W2088045602 hasConceptScore W2088045602C142724271 @default.
• W2088045602 hasConceptScore W2088045602C150194340 @default.
• W2088045602 hasConceptScore W2088045602C2776664737 @default.
• W2088045602 hasConceptScore W2088045602C2777521186 @default.
• W2088045602 hasConceptScore W2088045602C2779863012 @default.
• W2088045602 hasConceptScore W2088045602C2780091579 @default.
• W2088045602 hasConceptScore W2088045602C2781040948 @default.
• W2088045602 hasConceptScore W2088045602C55493867 @default.
• W2088045602 hasConceptScore W2088045602C71924100 @default.
• W2088045602 hasConceptScore W2088045602C77411442 @default.
• W2088045602 hasConceptScore W2088045602C86803240 @default.
• W2088045602 hasIssue "1" @default.
• W2088045602 hasLocation W20880456021 @default.
• W2088045602 hasLocation W20880456022 @default.
• W2088045602 hasOpenAccess W2088045602 @default.
• W2088045602 hasPrimaryLocation W20880456021 @default.
• W2088045602 hasRelatedWork W1964495689 @default.
• W2088045602 hasRelatedWork W2020959757 @default.

• next