Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088046543> ?p ?o ?g. }
- W2088046543 endingPage "737" @default.
- W2088046543 startingPage "715" @default.
- W2088046543 abstract "This review examines the ways in which dominant–subordinate behavior in animals, as determined in laboratory studies, can be used to model depression and mania in humans. Affective disorders are mood illnesses with two opposite poles, melancholia (depression) and mania that are expressed to different degrees in affected individuals. Dominance and submissiveness are also two contrasting behavioral poles distributed as a continuum along an axis with less or more dominant or submissive animals. The premise of this article is that important elements of both mania and depression can be modeled in rats and mice based on observation of dominant and submissive behavior exhibited under well defined conditions. Studies from our own research, where dominance and submissiveness are defined in a competition test and measured as the relative success of two food-restricted rats to gain access to a feeder, have yielded a paradigm that we call the Dominant Submissive Relationship (DSR). This paradigm results in two models sensitive to drugs used to treat mood disorders. Specifically, drugs used to treat mania inhibit the dominant behavior of rats gaining access to food at the expense of an opponent (Reduction of Dominant Behavior Model or RDBM), whereas antidepressants counteract the behavior of rats losing such encounters; Reduction of Submissive Behavior Model (RSBM). The validation of these models, as well as their advantages and limitations, are discussed and compared with other animal paradigms that utilize animal social behavior to model human mood disturbances." @default.
- W2088046543 created "2016-06-24" @default.
- W2088046543 creator A5052911891 @default.
- W2088046543 creator A5074827721 @default.
- W2088046543 date "2005-01-01" @default.
- W2088046543 modified "2023-09-25" @default.
- W2088046543 title "Dominant–submissive behavior as models of mania and depression" @default.
- W2088046543 cites W1757887121 @default.
- W2088046543 cites W1960686950 @default.
- W2088046543 cites W1965696501 @default.
- W2088046543 cites W1965879244 @default.
- W2088046543 cites W1966295021 @default.
- W2088046543 cites W1966587065 @default.
- W2088046543 cites W1967047746 @default.
- W2088046543 cites W1967679048 @default.
- W2088046543 cites W1970539422 @default.
- W2088046543 cites W1971701459 @default.
- W2088046543 cites W1973304036 @default.
- W2088046543 cites W1975600279 @default.
- W2088046543 cites W1979008433 @default.
- W2088046543 cites W1979355353 @default.
- W2088046543 cites W1982277568 @default.
- W2088046543 cites W1985307269 @default.
- W2088046543 cites W1985450372 @default.
- W2088046543 cites W1985691553 @default.
- W2088046543 cites W1986673346 @default.
- W2088046543 cites W1988962090 @default.
- W2088046543 cites W1989954292 @default.
- W2088046543 cites W1990603613 @default.
- W2088046543 cites W1991201649 @default.
- W2088046543 cites W1992175858 @default.
- W2088046543 cites W1992186274 @default.
- W2088046543 cites W1993415415 @default.
- W2088046543 cites W1994096357 @default.
- W2088046543 cites W1998580054 @default.
- W2088046543 cites W2000610098 @default.
- W2088046543 cites W2001249543 @default.
- W2088046543 cites W2002057152 @default.
- W2088046543 cites W2002169109 @default.
- W2088046543 cites W2005128569 @default.
- W2088046543 cites W2005950756 @default.
- W2088046543 cites W2008826625 @default.
- W2088046543 cites W2010269783 @default.
- W2088046543 cites W2012861818 @default.
- W2088046543 cites W2013579180 @default.
- W2088046543 cites W2018456716 @default.
- W2088046543 cites W2018604620 @default.
- W2088046543 cites W2020147283 @default.
- W2088046543 cites W2021069714 @default.
- W2088046543 cites W2021841620 @default.
- W2088046543 cites W2023265126 @default.
- W2088046543 cites W2023464568 @default.
- W2088046543 cites W2023908369 @default.
- W2088046543 cites W2024448817 @default.
- W2088046543 cites W2024493419 @default.
- W2088046543 cites W2025000270 @default.
- W2088046543 cites W2025066281 @default.
- W2088046543 cites W2025484712 @default.
- W2088046543 cites W2026438823 @default.
- W2088046543 cites W2029822846 @default.
- W2088046543 cites W2030869048 @default.
- W2088046543 cites W2032932763 @default.
- W2088046543 cites W2034272531 @default.
- W2088046543 cites W2035558638 @default.
- W2088046543 cites W2035865479 @default.
- W2088046543 cites W2037434120 @default.
- W2088046543 cites W2039252917 @default.
- W2088046543 cites W2039996819 @default.
- W2088046543 cites W2041195576 @default.
- W2088046543 cites W2044033981 @default.
- W2088046543 cites W2044183177 @default.
- W2088046543 cites W2047121031 @default.
- W2088046543 cites W2048457021 @default.
- W2088046543 cites W2048595403 @default.
- W2088046543 cites W2050512750 @default.
- W2088046543 cites W2051441198 @default.
- W2088046543 cites W2051446251 @default.
- W2088046543 cites W2052027999 @default.
- W2088046543 cites W2054507179 @default.
- W2088046543 cites W2054968781 @default.
- W2088046543 cites W2055054167 @default.
- W2088046543 cites W2056086807 @default.
- W2088046543 cites W2057299377 @default.
- W2088046543 cites W2057317784 @default.
- W2088046543 cites W2057922606 @default.
- W2088046543 cites W2058791014 @default.
- W2088046543 cites W2060854689 @default.
- W2088046543 cites W2062298899 @default.
- W2088046543 cites W2064212981 @default.
- W2088046543 cites W2064884441 @default.
- W2088046543 cites W2065153248 @default.
- W2088046543 cites W2068510950 @default.
- W2088046543 cites W2068560382 @default.
- W2088046543 cites W2068815553 @default.
- W2088046543 cites W2069147769 @default.
- W2088046543 cites W2070656240 @default.
- W2088046543 cites W2071240457 @default.
- W2088046543 cites W2071509654 @default.