Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088046895> ?p ?o ?g. }
- W2088046895 endingPage "510" @default.
- W2088046895 startingPage "502" @default.
- W2088046895 abstract "New targeted anti-inflammatory drugs have revolutionized the therapeutic strategies in rheumatology. Recombinant DNA selection technologies have enabled the isolation and humanization of specific antibody fragments of any specificity that can be ‘armed’ to deliver effective anti-inflammatory ‘payloads’. Antibodies and other targeted provide the opportunity to block key soluble mediators of inflammation in their milieu, or alternatively to block intracellular inflammation-triggering pathways by binding to an upstream cell-surface receptor. Designed proteins can be improved with respect to desired pharmacokinetic and pharmacodynamic effects. They facilitate the delivery of the required immunosuppressive effect. However, the individual extent of desired and undesired effects of a particular biologic therapy can be broader than initially predicted and requires careful evaluation during clinical trials. This review highlights advances in the application of recombinant antibody technology for novel biologic therapies in rheumatology." @default.
- W2088046895 created "2016-06-24" @default.
- W2088046895 creator A5015549021 @default.
- W2088046895 creator A5036850777 @default.
- W2088046895 date "2011-09-01" @default.
- W2088046895 modified "2023-10-14" @default.
- W2088046895 title "Recombinant proteins in rheumatology – recent advances" @default.
- W2088046895 cites W1534063614 @default.
- W2088046895 cites W1976537150 @default.
- W2088046895 cites W1980345972 @default.
- W2088046895 cites W1980725734 @default.
- W2088046895 cites W1987135399 @default.
- W2088046895 cites W1993067667 @default.
- W2088046895 cites W1993575340 @default.
- W2088046895 cites W1995276823 @default.
- W2088046895 cites W1998003752 @default.
- W2088046895 cites W2002477089 @default.
- W2088046895 cites W2008709724 @default.
- W2088046895 cites W2026865649 @default.
- W2088046895 cites W2028839726 @default.
- W2088046895 cites W2030476352 @default.
- W2088046895 cites W2049324939 @default.
- W2088046895 cites W2049623193 @default.
- W2088046895 cites W2053620243 @default.
- W2088046895 cites W2054383673 @default.
- W2088046895 cites W2055495515 @default.
- W2088046895 cites W2058858133 @default.
- W2088046895 cites W2060208115 @default.
- W2088046895 cites W2063340779 @default.
- W2088046895 cites W2066991166 @default.
- W2088046895 cites W2071080861 @default.
- W2088046895 cites W2073489229 @default.
- W2088046895 cites W2073851342 @default.
- W2088046895 cites W2075785757 @default.
- W2088046895 cites W2087638630 @default.
- W2088046895 cites W2088446845 @default.
- W2088046895 cites W2088691921 @default.
- W2088046895 cites W2089023076 @default.
- W2088046895 cites W2089068941 @default.
- W2088046895 cites W2092646113 @default.
- W2088046895 cites W2102572875 @default.
- W2088046895 cites W2106964599 @default.
- W2088046895 cites W2109844644 @default.
- W2088046895 cites W2136445320 @default.
- W2088046895 cites W2138788677 @default.
- W2088046895 cites W2139339400 @default.
- W2088046895 cites W2140859187 @default.
- W2088046895 cites W2141111992 @default.
- W2088046895 cites W2141989396 @default.
- W2088046895 cites W2145249112 @default.
- W2088046895 cites W2155338471 @default.
- W2088046895 cites W2157769714 @default.
- W2088046895 cites W2158342449 @default.
- W2088046895 cites W2158777708 @default.
- W2088046895 cites W2163058169 @default.
- W2088046895 cites W2166360124 @default.
- W2088046895 cites W2169160438 @default.
- W2088046895 cites W2328587823 @default.
- W2088046895 cites W90110751 @default.
- W2088046895 cites W159267763 @default.
- W2088046895 doi "https://doi.org/10.1016/j.nbt.2011.03.019" @default.
- W2088046895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21473939" @default.
- W2088046895 hasPublicationYear "2011" @default.
- W2088046895 type Work @default.
- W2088046895 sameAs 2088046895 @default.
- W2088046895 citedByCount "3" @default.
- W2088046895 countsByYear W20880468952012 @default.
- W2088046895 countsByYear W20880468952014 @default.
- W2088046895 countsByYear W20880468952015 @default.
- W2088046895 crossrefType "journal-article" @default.
- W2088046895 hasAuthorship W2088046895A5015549021 @default.
- W2088046895 hasAuthorship W2088046895A5036850777 @default.
- W2088046895 hasConcept C104317684 @default.
- W2088046895 hasConcept C126322002 @default.
- W2088046895 hasConcept C159654299 @default.
- W2088046895 hasConcept C185592680 @default.
- W2088046895 hasConcept C198451711 @default.
- W2088046895 hasConcept C203014093 @default.
- W2088046895 hasConcept C2776914184 @default.
- W2088046895 hasConcept C40767141 @default.
- W2088046895 hasConcept C55493867 @default.
- W2088046895 hasConcept C70721500 @default.
- W2088046895 hasConcept C71924100 @default.
- W2088046895 hasConcept C86803240 @default.
- W2088046895 hasConcept C98274493 @default.
- W2088046895 hasConceptScore W2088046895C104317684 @default.
- W2088046895 hasConceptScore W2088046895C126322002 @default.
- W2088046895 hasConceptScore W2088046895C159654299 @default.
- W2088046895 hasConceptScore W2088046895C185592680 @default.
- W2088046895 hasConceptScore W2088046895C198451711 @default.
- W2088046895 hasConceptScore W2088046895C203014093 @default.
- W2088046895 hasConceptScore W2088046895C2776914184 @default.
- W2088046895 hasConceptScore W2088046895C40767141 @default.
- W2088046895 hasConceptScore W2088046895C55493867 @default.
- W2088046895 hasConceptScore W2088046895C70721500 @default.
- W2088046895 hasConceptScore W2088046895C71924100 @default.
- W2088046895 hasConceptScore W2088046895C86803240 @default.
- W2088046895 hasConceptScore W2088046895C98274493 @default.