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- W2088049013 abstract "Abstract Gene therapy is a promising tool to tackle challenging diseases at a molecular level. However, delivery of therapeutic nucleic acids to desired tissues and cells with high efficiency, versatility, and safety has been a fundamental technological gap in gene therapy. Viral and nonviral vectors offer advantages and disadvantages that can complement each other. Viral vectors exhibit high transduction efficiency with immunogenicity, mutagenesis, and limited versatility for structural and functional tenability. On the other hand, low transfection efficiency of nonviral vectors undermines their high flexibility for modification, low immunogenicity, and easy preparation. A number of attempts have been made to hybridize viral and nonviral vectors using genetic, physical, and chemical approaches. Synthetic engineering of viral vectors is reviewed here with (1) challenges in viral nucleic acid delivery pathways, in contrast to those of nonviral vectors, (2) design goals of incorporating synthetic molecules of broad types into viral vectors, and (3) methodology to modify and re-formulate viral vectors. Recent advances in synthetically engineered viral vectors for various biomedical applications are also discussed. This review clearly emphasizes the crucial roles of interdisciplinary approaches to developing ideal vectors in order to obtain desired properties for clinical success." @default.
- W2088049013 created "2016-06-24" @default.
- W2088049013 creator A5025699995 @default.
- W2088049013 creator A5049528038 @default.
- W2088049013 date "2012-12-01" @default.
- W2088049013 modified "2023-09-27" @default.
- W2088049013 title "Synthetically engineered viruses: Can synthetic chemistry tame the nature?" @default.
- W2088049013 cites W1520821663 @default.
- W2088049013 cites W1965786463 @default.
- W2088049013 cites W1968152870 @default.
- W2088049013 cites W1970288095 @default.
- W2088049013 cites W1970767319 @default.
- W2088049013 cites W1975048313 @default.
- W2088049013 cites W1976892064 @default.
- W2088049013 cites W1982619130 @default.
- W2088049013 cites W1983679894 @default.
- W2088049013 cites W1985889861 @default.
- W2088049013 cites W1988177186 @default.
- W2088049013 cites W1988217789 @default.
- W2088049013 cites W1989736806 @default.
- W2088049013 cites W1990369593 @default.
- W2088049013 cites W1995307551 @default.
- W2088049013 cites W1999228064 @default.
- W2088049013 cites W1999472959 @default.
- W2088049013 cites W2005307847 @default.
- W2088049013 cites W2005958375 @default.
- W2088049013 cites W2008453483 @default.
- W2088049013 cites W2009539707 @default.
- W2088049013 cites W2010655741 @default.
- W2088049013 cites W2010999882 @default.
- W2088049013 cites W2011063658 @default.
- W2088049013 cites W2016325791 @default.
- W2088049013 cites W2021242205 @default.
- W2088049013 cites W2021320094 @default.
- W2088049013 cites W2022277849 @default.
- W2088049013 cites W2022668894 @default.
- W2088049013 cites W2023903552 @default.
- W2088049013 cites W2024351675 @default.
- W2088049013 cites W2025592853 @default.
- W2088049013 cites W2029427411 @default.
- W2088049013 cites W2030545270 @default.
- W2088049013 cites W2034450785 @default.
- W2088049013 cites W2034974949 @default.
- W2088049013 cites W2037048276 @default.
- W2088049013 cites W2040493466 @default.
- W2088049013 cites W2042026190 @default.
- W2088049013 cites W2042964200 @default.
- W2088049013 cites W2044776450 @default.
- W2088049013 cites W2051159468 @default.
- W2088049013 cites W2052665217 @default.
- W2088049013 cites W2054790400 @default.
- W2088049013 cites W2056842925 @default.
- W2088049013 cites W2057569371 @default.
- W2088049013 cites W2060955788 @default.
- W2088049013 cites W2061013034 @default.
- W2088049013 cites W2061445615 @default.
- W2088049013 cites W2062061048 @default.
- W2088049013 cites W2062590613 @default.
- W2088049013 cites W2064140172 @default.
- W2088049013 cites W2065129646 @default.
- W2088049013 cites W2066791595 @default.
- W2088049013 cites W2067048467 @default.
- W2088049013 cites W2067379696 @default.
- W2088049013 cites W2070754430 @default.
- W2088049013 cites W2072891049 @default.
- W2088049013 cites W2073345957 @default.
- W2088049013 cites W2073527119 @default.
- W2088049013 cites W2073786015 @default.
- W2088049013 cites W2074353166 @default.
- W2088049013 cites W2078968390 @default.
- W2088049013 cites W2079355808 @default.
- W2088049013 cites W2081217456 @default.
- W2088049013 cites W2082641225 @default.
- W2088049013 cites W2086683789 @default.
- W2088049013 cites W2088632574 @default.
- W2088049013 cites W2092971129 @default.
- W2088049013 cites W2097801329 @default.
- W2088049013 cites W2099345438 @default.
- W2088049013 cites W2106852013 @default.
- W2088049013 cites W2112478022 @default.
- W2088049013 cites W2122522178 @default.
- W2088049013 cites W2132878122 @default.
- W2088049013 cites W2158004797 @default.
- W2088049013 cites W2315339390 @default.
- W2088049013 cites W2316811173 @default.
- W2088049013 cites W2317947423 @default.
- W2088049013 cites W2323746187 @default.
- W2088049013 cites W2327360223 @default.
- W2088049013 cites W4239885108 @default.
- W2088049013 cites W2009052163 @default.
- W2088049013 doi "https://doi.org/10.1016/j.cossms.2012.10.002" @default.
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