FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088050791> ?p ?o ?g. }

• W2088050791 endingPage "4677" @default.
• W2088050791 startingPage "4668" @default.
• W2088050791 abstract "Two single-nucleotide polymorphisms in the type 2 ryanodine receptor (RyR2) leading to the nonsynonymous amino acid replacements G1885E and G1886S are associated with arrhythmogenic right ventricular cardiomyopathy in patients who are carrying both of the corresponding RyR2 alleles. The functional properties of HEK293 cell lines isogenically expressing RyR2 mutants associated with arrhythmogenic right ventricular cardiomyopathy, RyR2-G1885E, RyR2-G1886S, RyR2-G1886D (mimicking a constitutively phosphorylated Ser(1886)), and the double mutant RyR2-G1885E/G1886S were investigated by analyzing the intracellular Ca(2+) release activity resulting from store-overload-induced calcium release. The substitution of serine for Gly(1886) caused a significant increase in the cellular Ca(2+) oscillation activity compared with RyR2 wild-type-expressing HEK293 cells. It was even more pronounced if glycine 1885 or 1886 was replaced by the acidic amino acids glutamate (G1885E) or aspartate (G1886D). Surprisingly, when both substitutions were introduced in the same RyR2 subunit (RyR2-G1885E/G1886S), the store-overload-induced calcium release activity was nearly completely abolished, although the Ca(2+) loading of the intracellular stores was markedly enhanced, and the channel still displayed substantial Ca(2+) release on stimulation by 5 mM caffeine. These results suggest that the adjacent glycines 1885 and 1886, located in the divergent region 3, are critical for the function and regulation of RyR2." @default.
• W2088050791 created "2016-06-24" @default.
• W2088050791 creator A5006790152 @default.
• W2088050791 creator A5017390709 @default.
• W2088050791 creator A5045202468 @default.
• W2088050791 creator A5054666828 @default.
• W2088050791 creator A5069171705 @default.
• W2088050791 date "2008-06-01" @default.
• W2088050791 modified "2023-10-18" @default.
• W2088050791 title "ARVC-Related Mutations in Divergent Region 3 Alter Functional Properties of the Cardiac Ryanodine Receptor" @default.
• W2088050791 cites W1981187216 @default.
• W2088050791 cites W1981674309 @default.
• W2088050791 cites W1983710068 @default.
• W2088050791 cites W1986328966 @default.
• W2088050791 cites W2007645700 @default.
• W2088050791 cites W2009039495 @default.
• W2088050791 cites W2018631567 @default.
• W2088050791 cites W2022714275 @default.
• W2088050791 cites W2033039093 @default.
• W2088050791 cites W2050750468 @default.
• W2088050791 cites W2060913542 @default.
• W2088050791 cites W2069593226 @default.
• W2088050791 cites W2081397479 @default.
• W2088050791 cites W2082633743 @default.
• W2088050791 cites W2086449013 @default.
• W2088050791 cites W2091399029 @default.
• W2088050791 cites W2095062180 @default.
• W2088050791 cites W2107748489 @default.
• W2088050791 cites W2137283585 @default.
• W2088050791 cites W2154620339 @default.
• W2088050791 cites W2159514656 @default.
• W2088050791 cites W2162079750 @default.
• W2088050791 doi "https://doi.org/10.1529/biophysj.107.122382" @default.
• W2088050791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2397357" @default.
• W2088050791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18326664" @default.
• W2088050791 hasPublicationYear "2008" @default.
• W2088050791 type Work @default.
• W2088050791 sameAs 2088050791 @default.
• W2088050791 citedByCount "26" @default.
• W2088050791 countsByYear W20880507912012 @default.
• W2088050791 countsByYear W20880507912013 @default.
• W2088050791 countsByYear W20880507912014 @default.
• W2088050791 countsByYear W20880507912015 @default.
• W2088050791 countsByYear W20880507912016 @default.
• W2088050791 countsByYear W20880507912017 @default.
• W2088050791 countsByYear W20880507912020 @default.
• W2088050791 countsByYear W20880507912021 @default.
• W2088050791 countsByYear W20880507912022 @default.
• W2088050791 countsByYear W20880507912023 @default.
• W2088050791 crossrefType "journal-article" @default.
• W2088050791 hasAuthorship W2088050791A5006790152 @default.
• W2088050791 hasAuthorship W2088050791A5017390709 @default.
• W2088050791 hasAuthorship W2088050791A5045202468 @default.
• W2088050791 hasAuthorship W2088050791A5054666828 @default.
• W2088050791 hasAuthorship W2088050791A5069171705 @default.
• W2088050791 hasBestOaLocation W20880507911 @default.
• W2088050791 hasConcept C104317684 @default.
• W2088050791 hasConcept C113217602 @default.
• W2088050791 hasConcept C141231307 @default.
• W2088050791 hasConcept C143065580 @default.
• W2088050791 hasConcept C149904235 @default.
• W2088050791 hasConcept C170493617 @default.
• W2088050791 hasConcept C174510640 @default.
• W2088050791 hasConcept C178790620 @default.
• W2088050791 hasConcept C181080969 @default.
• W2088050791 hasConcept C185592680 @default.
• W2088050791 hasConcept C190712762 @default.
• W2088050791 hasConcept C515207424 @default.
• W2088050791 hasConcept C519063684 @default.
• W2088050791 hasConcept C55493867 @default.
• W2088050791 hasConcept C79879829 @default.
• W2088050791 hasConcept C86803240 @default.
• W2088050791 hasConcept C95444343 @default.
• W2088050791 hasConceptScore W2088050791C104317684 @default.
• W2088050791 hasConceptScore W2088050791C113217602 @default.
• W2088050791 hasConceptScore W2088050791C141231307 @default.
• W2088050791 hasConceptScore W2088050791C143065580 @default.
• W2088050791 hasConceptScore W2088050791C149904235 @default.
• W2088050791 hasConceptScore W2088050791C170493617 @default.
• W2088050791 hasConceptScore W2088050791C174510640 @default.
• W2088050791 hasConceptScore W2088050791C178790620 @default.
• W2088050791 hasConceptScore W2088050791C181080969 @default.
• W2088050791 hasConceptScore W2088050791C185592680 @default.
• W2088050791 hasConceptScore W2088050791C190712762 @default.
• W2088050791 hasConceptScore W2088050791C515207424 @default.
• W2088050791 hasConceptScore W2088050791C519063684 @default.
• W2088050791 hasConceptScore W2088050791C55493867 @default.
• W2088050791 hasConceptScore W2088050791C79879829 @default.
• W2088050791 hasConceptScore W2088050791C86803240 @default.
• W2088050791 hasConceptScore W2088050791C95444343 @default.
• W2088050791 hasIssue "12" @default.
• W2088050791 hasLocation W20880507911 @default.
• W2088050791 hasLocation W20880507912 @default.
• W2088050791 hasLocation W20880507913 @default.
• W2088050791 hasLocation W20880507914 @default.
• W2088050791 hasOpenAccess W2088050791 @default.
• W2088050791 hasPrimaryLocation W20880507911 @default.
• W2088050791 hasRelatedWork W1964779834 @default.

• next