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• W2088059603 abstract "Fibronectin (Fn) is a 440 kDa glycoprotein assumed to participate in sperm–egg interaction in human. Recently, it has been demonstrated that Fn – when present during bovine IVF – strongly inhibits sperm penetration. The present study was conducted firstly to evaluate the expression of Fn and its integrin receptor (α 5 β 1 ) on male and female bovine gametes using indirect immunofluorescence and secondly, to determine the function of Fn during bovine IVF. Endogenous Fn was detected underneath the zona pellucida (ZP) and integrin α 5 on the oolemma of cumulus-denuded oocytes. Bovine spermatozoa displayed integrin α 5 at their equatorial segment after acrosome reaction. We established that the main inhibitory effect of exogenously supplemented Fn was located at the sperm–oolemma binding, with a (concurrent) effect on fusion, and this can probably be attributed to the binding of Fn to spermatozoa at the equatorial segment, as shown by means of Alexa Fluor 488-conjugated Fn. Combining these results, the inhibitory effect of exogenously supplemented Fn seemed to be exerted on the male gamete by binding to the exposed integrin α 5 β 1 receptor after acrosome reaction. The presence of endogenous Fn underneath the ZP together with integrin α 5 expression on oolemma and acrosome-reacted (AR) sperm cell surface suggests a ‘velcro’ interaction between the endogenous Fn ligand and corresponding receptors on both (AR) sperm cell and oolemma, initiating sperm–egg binding." @default.
• W2088059603 created "2016-06-24" @default.
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• W2088059603 date "2009-09-01" @default.
• W2088059603 modified "2023-10-01" @default.
• W2088059603 title "Expression and putative function of fibronectin and its receptor (integrin α5β1) in male and female gametes during bovine fertilization in vitro" @default.
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• W2088059603 doi "https://doi.org/10.1530/rep-09-0094" @default.
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