Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088067673> ?p ?o ?g. }
- W2088067673 endingPage "196" @default.
- W2088067673 startingPage "184" @default.
- W2088067673 abstract "Electron microscopy and biochemical studies indicate that developmental abnormalities in synaptic organization may be present in brains of schizophrenic patients. This study determined whether these synaptic abnormalities are reflected in differential or uniform alterations in the expression of various synaptic protein genes in the left superior temporal gyrus of schizophrenic patients.Levels of mRNAs encoding four synaptic vesicle proteins (synaptotagmin I [p65], rab3a, synaptobrevin 1, and synaptobrevin 2) and two synaptic plasma membrane proteins (syntaxin 1A and SNAP-25) were measured postmortem in the left superior temporal gyrus from elderly (58-95 years) schizophrenic patients (n = 14) and age-matched control subjects (n = 9).There were significant negative correlations between age and levels of synaptotagmin I (p65), rab3a, synaptobrevin 1, SNAP-25, and syntaxin 1A mRNAs in schizophrenic patients (-.692 < r < -.517,.003 < p <.030) but not in control subjects. Levels of all six synaptic mRNAs studied were increased in the younger (58-79 years) subgroup of schizophrenic patients compared to control subjects and older (80-95 years) subgroup of schizophrenic patients.That similar abnormalities were found for mRNAs encoding different synaptic vesicle and synaptic plasma membrane proteins suggests that they reflect overall neurodevelopmental abnormalities in synaptic connectivity in the temporal cortex of schizophrenic patients rather than changes in the number of synaptic vesicles per synapse or abnormalities in a specific synaptic function." @default.
- W2088067673 created "2016-06-24" @default.
- W2088067673 creator A5000219240 @default.
- W2088067673 creator A5008735636 @default.
- W2088067673 creator A5054795331 @default.
- W2088067673 creator A5066690815 @default.
- W2088067673 date "2000-08-01" @default.
- W2088067673 modified "2023-10-10" @default.
- W2088067673 title "Levels of mRNAs encoding synaptic vesicle and synaptic plasma membrane proteins in the temporal cortex of elderly schizophrenic patients" @default.
- W2088067673 cites W1226482428 @default.
- W2088067673 cites W1491903356 @default.
- W2088067673 cites W1511501308 @default.
- W2088067673 cites W1520904574 @default.
- W2088067673 cites W1525752116 @default.
- W2088067673 cites W1555714096 @default.
- W2088067673 cites W1606131697 @default.
- W2088067673 cites W1657694742 @default.
- W2088067673 cites W1937144007 @default.
- W2088067673 cites W1964347513 @default.
- W2088067673 cites W1965403083 @default.
- W2088067673 cites W1969311327 @default.
- W2088067673 cites W1971695370 @default.
- W2088067673 cites W1977410909 @default.
- W2088067673 cites W1980214775 @default.
- W2088067673 cites W1981402761 @default.
- W2088067673 cites W1984953308 @default.
- W2088067673 cites W1988400201 @default.
- W2088067673 cites W1993683682 @default.
- W2088067673 cites W1994489140 @default.
- W2088067673 cites W1997240749 @default.
- W2088067673 cites W1997576450 @default.
- W2088067673 cites W2000242561 @default.
- W2088067673 cites W2010230693 @default.
- W2088067673 cites W2013617213 @default.
- W2088067673 cites W2019699695 @default.
- W2088067673 cites W2023316520 @default.
- W2088067673 cites W2025011978 @default.
- W2088067673 cites W2026965872 @default.
- W2088067673 cites W2041069875 @default.
- W2088067673 cites W2042897724 @default.
- W2088067673 cites W2043377800 @default.
- W2088067673 cites W2044162798 @default.
- W2088067673 cites W2046013073 @default.
- W2088067673 cites W2052785307 @default.
- W2088067673 cites W2053717239 @default.
- W2088067673 cites W2060642455 @default.
- W2088067673 cites W2077451533 @default.
- W2088067673 cites W2080791044 @default.
- W2088067673 cites W2083579475 @default.
- W2088067673 cites W2084772141 @default.
- W2088067673 cites W2085647154 @default.
- W2088067673 cites W2088717688 @default.
- W2088067673 cites W2090829912 @default.
- W2088067673 cites W2092602709 @default.
- W2088067673 cites W2092728840 @default.
- W2088067673 cites W2101850570 @default.
- W2088067673 cites W2113359311 @default.
- W2088067673 cites W2121999864 @default.
- W2088067673 cites W2123697751 @default.
- W2088067673 cites W2129090701 @default.
- W2088067673 cites W2132406375 @default.
- W2088067673 cites W2144451499 @default.
- W2088067673 cites W2146729934 @default.
- W2088067673 cites W2171405125 @default.
- W2088067673 cites W2332722142 @default.
- W2088067673 cites W2885719476 @default.
- W2088067673 cites W61342229 @default.
- W2088067673 cites W73166056 @default.
- W2088067673 cites W84775351 @default.
- W2088067673 cites W97450362 @default.
- W2088067673 doi "https://doi.org/10.1016/s0006-3223(00)00875-1" @default.
- W2088067673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10924661" @default.
- W2088067673 hasPublicationYear "2000" @default.
- W2088067673 type Work @default.
- W2088067673 sameAs 2088067673 @default.
- W2088067673 citedByCount "78" @default.
- W2088067673 countsByYear W20880676732012 @default.
- W2088067673 countsByYear W20880676732013 @default.
- W2088067673 countsByYear W20880676732014 @default.
- W2088067673 countsByYear W20880676732015 @default.
- W2088067673 countsByYear W20880676732016 @default.
- W2088067673 countsByYear W20880676732017 @default.
- W2088067673 countsByYear W20880676732018 @default.
- W2088067673 countsByYear W20880676732019 @default.
- W2088067673 countsByYear W20880676732020 @default.
- W2088067673 countsByYear W20880676732021 @default.
- W2088067673 crossrefType "journal-article" @default.
- W2088067673 hasAuthorship W2088067673A5000219240 @default.
- W2088067673 hasAuthorship W2088067673A5008735636 @default.
- W2088067673 hasAuthorship W2088067673A5054795331 @default.
- W2088067673 hasAuthorship W2088067673A5066690815 @default.
- W2088067673 hasConcept C112592302 @default.
- W2088067673 hasConcept C125667969 @default.
- W2088067673 hasConcept C126322002 @default.
- W2088067673 hasConcept C127445978 @default.
- W2088067673 hasConcept C130316041 @default.
- W2088067673 hasConcept C134018914 @default.
- W2088067673 hasConcept C134499376 @default.