Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088067986> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2088067986 endingPage "396" @default.
- W2088067986 startingPage "396" @default.
- W2088067986 abstract "Dopamine (DA) D1 agonists are classified as high- or low-efficacy on the basis of in vitro functional measures as compared to DA. In monkeys self-administering cocaine, high-efficacy D1 agonists have been shown to have reinforcing effects, while low-efficacy agonists do not. However, the relationship between D1 agonist efficacy and cocaine-like discriminative stimulus effects, particularly in rhesus monkeys, is not clear. The present study investigated the discriminative stimulus effects of a high- (SKF 81297) and a low-efficacy (SKF 38393) D1 agonist in rhesus monkeys (n=4) trained to discriminate cocaine from saline using a two-lever drug discrimination procedure. In a second experiment, the effects of agonist pretreatments, as well as pretreatment with a D1 antagonist, on cocaine's discriminative stimulus effects were evaluated. SKF 81297 (0.01–1.7 mg/kg) fully substituted for cocaine in three of four animals (>80% cocaine-appropriate responding), while SKF 38393 (0.3–10 mg/kg) occasioned <50% cocaine-appropriate responding in all subjects. When given as a pretreatment, neither agonist altered cocaine's discriminative stimulus effects at the doses tested. In contrast, the D1 antagonist SCH 23390 attenuated cocaine's discriminative stimulus effects. These results indicate that D1 agonists have cocaine-like discriminative stimulus effects in rhesus monkeys that are consistent with their in vitro efficacies. However, when given in combination with cocaine, D1 agonist efficacy does not appear to be a major factor in modifying cocaine's discriminative stimulus effects." @default.
- W2088067986 created "2016-06-24" @default.
- W2088067986 creator A5000965015 @default.
- W2088067986 creator A5017366585 @default.
- W2088067986 creator A5032119531 @default.
- W2088067986 creator A5068321695 @default.
- W2088067986 date "1993-09-01" @default.
- W2088067986 modified "2023-09-25" @default.
- W2088067986 title "Atypical neuroleptic profile of S 14506, a high affinity 5-HT1A agonist with D-2 and 5-HT1C antagonist activities" @default.
- W2088067986 cites W2086393860 @default.
- W2088067986 doi "https://doi.org/10.1016/0924-977x(93)90188-r" @default.
- W2088067986 hasPublicationYear "1993" @default.
- W2088067986 type Work @default.
- W2088067986 sameAs 2088067986 @default.
- W2088067986 citedByCount "1" @default.
- W2088067986 crossrefType "journal-article" @default.
- W2088067986 hasAuthorship W2088067986A5000965015 @default.
- W2088067986 hasAuthorship W2088067986A5017366585 @default.
- W2088067986 hasAuthorship W2088067986A5032119531 @default.
- W2088067986 hasAuthorship W2088067986A5068321695 @default.
- W2088067986 hasConcept C126322002 @default.
- W2088067986 hasConcept C15744967 @default.
- W2088067986 hasConcept C169760540 @default.
- W2088067986 hasConcept C170493617 @default.
- W2088067986 hasConcept C2776885963 @default.
- W2088067986 hasConcept C2778258207 @default.
- W2088067986 hasConcept C2778938600 @default.
- W2088067986 hasConcept C2779547902 @default.
- W2088067986 hasConcept C2779917531 @default.
- W2088067986 hasConcept C57022672 @default.
- W2088067986 hasConcept C58732023 @default.
- W2088067986 hasConcept C71924100 @default.
- W2088067986 hasConcept C98274493 @default.
- W2088067986 hasConceptScore W2088067986C126322002 @default.
- W2088067986 hasConceptScore W2088067986C15744967 @default.
- W2088067986 hasConceptScore W2088067986C169760540 @default.
- W2088067986 hasConceptScore W2088067986C170493617 @default.
- W2088067986 hasConceptScore W2088067986C2776885963 @default.
- W2088067986 hasConceptScore W2088067986C2778258207 @default.
- W2088067986 hasConceptScore W2088067986C2778938600 @default.
- W2088067986 hasConceptScore W2088067986C2779547902 @default.
- W2088067986 hasConceptScore W2088067986C2779917531 @default.
- W2088067986 hasConceptScore W2088067986C57022672 @default.
- W2088067986 hasConceptScore W2088067986C58732023 @default.
- W2088067986 hasConceptScore W2088067986C71924100 @default.
- W2088067986 hasConceptScore W2088067986C98274493 @default.
- W2088067986 hasIssue "3" @default.
- W2088067986 hasLocation W20880679861 @default.
- W2088067986 hasOpenAccess W2088067986 @default.
- W2088067986 hasPrimaryLocation W20880679861 @default.
- W2088067986 hasRelatedWork W1972795403 @default.
- W2088067986 hasRelatedWork W1981062366 @default.
- W2088067986 hasRelatedWork W2009355260 @default.
- W2088067986 hasRelatedWork W2009536591 @default.
- W2088067986 hasRelatedWork W2009579516 @default.
- W2088067986 hasRelatedWork W2009652649 @default.
- W2088067986 hasRelatedWork W2055953604 @default.
- W2088067986 hasRelatedWork W2063828160 @default.
- W2088067986 hasRelatedWork W2072822407 @default.
- W2088067986 hasRelatedWork W2220256369 @default.
- W2088067986 hasVolume "3" @default.
- W2088067986 isParatext "false" @default.
- W2088067986 isRetracted "false" @default.
- W2088067986 magId "2088067986" @default.
- W2088067986 workType "article" @default.