Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088081567> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2088081567 endingPage "1288" @default.
- W2088081567 startingPage "1284" @default.
- W2088081567 abstract "In this study, a series of N-chloro-acetylated dipeptides were synthesised by the application of Houghten’s methodology of multiple analog peptide syntheses (MAPS). The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase activity of the protease. We have succeeded in obtaining a number of effective inactivators, the most potent of which—chloroacetyl-Leu-Leu-OH, inactivates the enzyme with an apparent second-order rate constant of 3.8 × 104 M−1 min−1. In contrast, the esterified analog, chloroacetyl-Leu-Leu-OMe, inactivates the enzyme some three orders of magnitude less efficiently, lending credence to our thesis that a free carboxylic acid moiety is an important determinant for inhibitor effectiveness. This preliminary study has highlighted a number of interesting features about the specificity requirements of the bovine proteinase and we believe that our approach has great potential for the rapid delineation of the subsite specificities of cathepsin B-like proteases from various species." @default.
- W2088081567 created "2016-06-24" @default.
- W2088081567 creator A5053533247 @default.
- W2088081567 creator A5066982091 @default.
- W2088081567 creator A5085991081 @default.
- W2088081567 date "2005-08-01" @default.
- W2088081567 modified "2023-09-23" @default.
- W2088081567 title "The inactivation of bovine cathepsin B by novel N-chloro-acetyl-dipeptides: Application of the Houghten ‘tea bag’ methodology to inhibitor synthesis" @default.
- W2088081567 cites W1506802130 @default.
- W2088081567 cites W1530246363 @default.
- W2088081567 cites W1845792010 @default.
- W2088081567 cites W1985469117 @default.
- W2088081567 cites W2004381546 @default.
- W2088081567 cites W2024172270 @default.
- W2088081567 cites W2048161522 @default.
- W2088081567 cites W2049922066 @default.
- W2088081567 cites W2059426057 @default.
- W2088081567 cites W2060186655 @default.
- W2088081567 cites W2086378370 @default.
- W2088081567 cites W2094954825 @default.
- W2088081567 cites W2102795024 @default.
- W2088081567 cites W2200791553 @default.
- W2088081567 cites W2332555256 @default.
- W2088081567 cites W2395236462 @default.
- W2088081567 doi "https://doi.org/10.1016/j.bbrc.2005.06.033" @default.
- W2088081567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15978544" @default.
- W2088081567 hasPublicationYear "2005" @default.
- W2088081567 type Work @default.
- W2088081567 sameAs 2088081567 @default.
- W2088081567 citedByCount "3" @default.
- W2088081567 countsByYear W20880815672015 @default.
- W2088081567 crossrefType "journal-article" @default.
- W2088081567 hasAuthorship W2088081567A5053533247 @default.
- W2088081567 hasAuthorship W2088081567A5066982091 @default.
- W2088081567 hasAuthorship W2088081567A5085991081 @default.
- W2088081567 hasConcept C13935069 @default.
- W2088081567 hasConcept C167844969 @default.
- W2088081567 hasConcept C181199279 @default.
- W2088081567 hasConcept C182220744 @default.
- W2088081567 hasConcept C185592680 @default.
- W2088081567 hasConcept C2776568683 @default.
- W2088081567 hasConcept C2776980637 @default.
- W2088081567 hasConcept C2777132095 @default.
- W2088081567 hasConcept C2777283782 @default.
- W2088081567 hasConcept C2779281246 @default.
- W2088081567 hasConcept C2781338088 @default.
- W2088081567 hasConcept C28021979 @default.
- W2088081567 hasConcept C55493867 @default.
- W2088081567 hasConcept C71240020 @default.
- W2088081567 hasConceptScore W2088081567C13935069 @default.
- W2088081567 hasConceptScore W2088081567C167844969 @default.
- W2088081567 hasConceptScore W2088081567C181199279 @default.
- W2088081567 hasConceptScore W2088081567C182220744 @default.
- W2088081567 hasConceptScore W2088081567C185592680 @default.
- W2088081567 hasConceptScore W2088081567C2776568683 @default.
- W2088081567 hasConceptScore W2088081567C2776980637 @default.
- W2088081567 hasConceptScore W2088081567C2777132095 @default.
- W2088081567 hasConceptScore W2088081567C2777283782 @default.
- W2088081567 hasConceptScore W2088081567C2779281246 @default.
- W2088081567 hasConceptScore W2088081567C2781338088 @default.
- W2088081567 hasConceptScore W2088081567C28021979 @default.
- W2088081567 hasConceptScore W2088081567C55493867 @default.
- W2088081567 hasConceptScore W2088081567C71240020 @default.
- W2088081567 hasIssue "4" @default.
- W2088081567 hasLocation W20880815671 @default.
- W2088081567 hasLocation W20880815672 @default.
- W2088081567 hasOpenAccess W2088081567 @default.
- W2088081567 hasPrimaryLocation W20880815671 @default.
- W2088081567 hasRelatedWork W1984164374 @default.
- W2088081567 hasRelatedWork W1984532093 @default.
- W2088081567 hasRelatedWork W2076932799 @default.
- W2088081567 hasRelatedWork W2102792735 @default.
- W2088081567 hasRelatedWork W2119193879 @default.
- W2088081567 hasRelatedWork W2157466129 @default.
- W2088081567 hasRelatedWork W2181253379 @default.
- W2088081567 hasRelatedWork W2320305384 @default.
- W2088081567 hasRelatedWork W2327604056 @default.
- W2088081567 hasRelatedWork W2952418774 @default.
- W2088081567 hasVolume "333" @default.
- W2088081567 isParatext "false" @default.
- W2088081567 isRetracted "false" @default.
- W2088081567 magId "2088081567" @default.
- W2088081567 workType "article" @default.