FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088086136> ?p ?o ?g. }

• W2088086136 endingPage "50" @default.
• W2088086136 startingPage "43" @default.
• W2088086136 abstract "TNFalpha converting enzyme (TACE) is the major metalloproteinase for the processing of TNFalpha, a key inflammatory cytokine. IK682, a hydroxamate compound, was reported to be a potent and specific TACE inhibitor [J.J. Duan, L. Chen, Z.R. Wasserman, Z. Lu, R.Q. Liu, M.B. Covington, M. Qian, K.D. Hardman, R.L. Magolda, R.C. Newton, D.D. Christ, R.R. Wexler, C.P. Decicco, J. Med. Chem. 45 (2002) 4954-4957]. The binding kinetics of IK682 and the ectodomain of human TACE was examined. The k(on) of IK682 was determined as 1.1+/-0.3 x 10(8) M(-1) min(-1). No detectable dissociation of IK682 from TACE was observed following dialysis, dilution, and extensive washing over a maximum of 72 h. This was in contrast to the rapid dissociation of IK682 from ADAM10. LC/MS analysis of the TACE-IK682 complex after dissociation under denaturing conditions indicated that the tight binding is not due to covalent interaction. The X-ray crystal structure of TACE-IK682 complex revealed multiple binding points at the S1' and S3' sites and the movement of a loop (from Ala349 to Gly442) to accommodate the binding of the quinolinyl group of IK682 at the S3' pocket. The conformational changes of TACE may contribute significantly to the high affinity binding as a result of a more stable TACE-inhibitor complex." @default.
• W2088086136 created "2016-06-24" @default.
• W2088086136 creator A5014050332 @default.
• W2088086136 creator A5022095239 @default.
• W2088086136 creator A5053134006 @default.
• W2088086136 creator A5058901392 @default.
• W2088086136 creator A5061618319 @default.
• W2088086136 creator A5067834531 @default.
• W2088086136 creator A5075786952 @default.
• W2088086136 creator A5077493594 @default.
• W2088086136 date "2006-07-01" @default.
• W2088086136 modified "2023-09-23" @default.
• W2088086136 title "IK682, a tight binding inhibitor of TACE" @default.
• W2088086136 cites W1835135188 @default.
• W2088086136 cites W1965065447 @default.
• W2088086136 cites W1983051953 @default.
• W2088086136 cites W1989228411 @default.
• W2088086136 cites W1994971225 @default.
• W2088086136 cites W2001641653 @default.
• W2088086136 cites W2009073915 @default.
• W2088086136 cites W2019012381 @default.
• W2088086136 cites W2026775625 @default.
• W2088086136 cites W2028231353 @default.
• W2088086136 cites W2036842448 @default.
• W2088086136 cites W2038377232 @default.
• W2088086136 cites W2039408139 @default.
• W2088086136 cites W2041717330 @default.
• W2088086136 cites W2045126291 @default.
• W2088086136 cites W2050243158 @default.
• W2088086136 cites W2062784484 @default.
• W2088086136 cites W2066555692 @default.
• W2088086136 cites W2071885136 @default.
• W2088086136 cites W2074881372 @default.
• W2088086136 cites W2078248419 @default.
• W2088086136 cites W2079474526 @default.
• W2088086136 cites W2094559285 @default.
• W2088086136 cites W2105091660 @default.
• W2088086136 cites W2119445810 @default.
• W2088086136 cites W2145837099 @default.
• W2088086136 cites W2210033643 @default.
• W2088086136 doi "https://doi.org/10.1016/j.abb.2006.03.034" @default.
• W2088086136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16762314" @default.
• W2088086136 hasPublicationYear "2006" @default.
• W2088086136 type Work @default.
• W2088086136 sameAs 2088086136 @default.
• W2088086136 citedByCount "47" @default.
• W2088086136 countsByYear W20880861362012 @default.
• W2088086136 countsByYear W20880861362013 @default.
• W2088086136 countsByYear W20880861362014 @default.
• W2088086136 countsByYear W20880861362015 @default.
• W2088086136 countsByYear W20880861362016 @default.
• W2088086136 countsByYear W20880861362017 @default.
• W2088086136 countsByYear W20880861362018 @default.
• W2088086136 countsByYear W20880861362019 @default.
• W2088086136 countsByYear W20880861362020 @default.
• W2088086136 countsByYear W20880861362021 @default.
• W2088086136 countsByYear W20880861362022 @default.
• W2088086136 countsByYear W20880861362023 @default.
• W2088086136 crossrefType "journal-article" @default.
• W2088086136 hasAuthorship W2088086136A5014050332 @default.
• W2088086136 hasAuthorship W2088086136A5022095239 @default.
• W2088086136 hasAuthorship W2088086136A5053134006 @default.
• W2088086136 hasAuthorship W2088086136A5058901392 @default.
• W2088086136 hasAuthorship W2088086136A5061618319 @default.
• W2088086136 hasAuthorship W2088086136A5067834531 @default.
• W2088086136 hasAuthorship W2088086136A5075786952 @default.
• W2088086136 hasAuthorship W2088086136A5077493594 @default.
• W2088086136 hasConcept C1009742 @default.
• W2088086136 hasConcept C107824862 @default.
• W2088086136 hasConcept C121332964 @default.
• W2088086136 hasConcept C148898269 @default.
• W2088086136 hasConcept C170493617 @default.
• W2088086136 hasConcept C181199279 @default.
• W2088086136 hasConcept C185592680 @default.
• W2088086136 hasConcept C55493867 @default.
• W2088086136 hasConcept C62520636 @default.
• W2088086136 hasConcept C71240020 @default.
• W2088086136 hasConcept C74998103 @default.
• W2088086136 hasConceptScore W2088086136C1009742 @default.
• W2088086136 hasConceptScore W2088086136C107824862 @default.
• W2088086136 hasConceptScore W2088086136C121332964 @default.
• W2088086136 hasConceptScore W2088086136C148898269 @default.
• W2088086136 hasConceptScore W2088086136C170493617 @default.
• W2088086136 hasConceptScore W2088086136C181199279 @default.
• W2088086136 hasConceptScore W2088086136C185592680 @default.
• W2088086136 hasConceptScore W2088086136C55493867 @default.
• W2088086136 hasConceptScore W2088086136C62520636 @default.
• W2088086136 hasConceptScore W2088086136C71240020 @default.
• W2088086136 hasConceptScore W2088086136C74998103 @default.
• W2088086136 hasIssue "1" @default.
• W2088086136 hasLocation W20880861361 @default.
• W2088086136 hasLocation W20880861362 @default.
• W2088086136 hasOpenAccess W2088086136 @default.
• W2088086136 hasPrimaryLocation W20880861361 @default.
• W2088086136 hasRelatedWork W1687667812 @default.
• W2088086136 hasRelatedWork W1991375245 @default.
• W2088086136 hasRelatedWork W1992151770 @default.
• W2088086136 hasRelatedWork W2001811442 @default.

• next