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• W2088094564 abstract "NOTCH signaling plays a key role in cell fate determination in both vertebrates and invertebrates. It is well known that Su(H)/RBP‐J is a major mediator of NOTCH signaling. In a previous study, it was shown that NOTCH signaling was involved in cranial neural crest formation in avian embryos. However, Su(H)/RBP‐J activity did not appear to be required in this process. In this study, the Deltex/Dtx gene was focussed on as a potential mediator of NOTCH signaling in neural crest formation. At the time of neural crest formation, quail Deltex2 was expressed throughout the ectoderm. Misexpression of a dominant‐negative form of Deltex in the ectoderm caused reduced expression of Slug , a neural crest marker. Dominant‐negative Deltex expression reduced the expression of Bmp4 , a neural crest inducer, whereas co‐transfection of Bmp4 with dominant‐negative Deltex rescued Slug expression. In parallel, Hairy2 expression in the epidermis was regulated by a Su(H) ‐dependent pathway. These results indicate that NOTCH signaling has dual functions mediated by either Su(H) or Deltex in the avian embryonic ectoderm." @default.
• W2088094564 created "2016-06-24" @default.
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• W2088094564 date "2003-06-01" @default.
• W2088094564 modified "2023-10-14" @default.
• W2088094564 title "Deltex/Dtx mediates NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development" @default.
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• W2088094564 doi "https://doi.org/10.1046/j.1524-4725.2003.693.x" @default.
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