FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088105713> ?p ?o ?g. }

• W2088105713 endingPage "230" @default.
• W2088105713 startingPage "223" @default.
• W2088105713 abstract "Wnt proteins that signal via the canonical Wnt/β-catenin pathway directly regulate osteoblast differentiation. In contrast, most studies of Wnt-related effects on osteoclasts involve indirect changes. While investigating bone mineral density loss in the setting of human immunodeficiency virus (HIV) infection and its treatment with the protease inhibitor ritonavir (RTV), we observed that RTV decreased nuclear localization of β-catenin, critical to canonical Wnt signaling, in primary human and murine osteoclast precursors. This occurred in parallel with upregulation of Wnt5a and Wnt5b transcripts. These Wnts typically stimulate noncanonical Wnt signaling, and this can antagonize the canonical Wnt pathway in many cell types, dependent upon Wnt receptor usage. We now document RTV-mediated upregulation of Wnt5a/b protein in osteoclast precursors. Recombinant Wnt5b and retrovirus-mediated expression of Wnt5a enhanced osteoclast differentiation from human and murine monocytic precursors, processes facilitated by RTV. In contrast, canonical Wnt signaling mediated by Wnt3a suppressed osteoclastogenesis. Both RTV and Wnt5b inhibited canonical, β-catenin/T cell factor-based Wnt reporter activation in osteoclast precursors. RTV- and Wnt5-induced osteoclast differentiation were dependent upon the receptor-like tyrosine kinase Ryk, suggesting that Ryk may act as a Wnt5a/b receptor in this context. This is the first demonstration of a direct role for Wnt signaling pathways and Ryk in regulation of osteoclast differentiation, and its modulation by a clinically important drug, ritonavir. These studies also reveal a potential role for noncanonical Wnt5a/b signaling in acceleration of bone mineral density loss in HIV-infected individuals, and illuminate a potential means of influencing such processes in disease states that involve enhanced osteoclast activity." @default.
• W2088105713 created "2016-06-24" @default.
• W2088105713 creator A5008731793 @default.
• W2088105713 creator A5044874669 @default.
• W2088105713 creator A5047150965 @default.
• W2088105713 creator A5069822390 @default.
• W2088105713 date "2012-01-01" @default.
• W2088105713 modified "2023-10-13" @default.
• W2088105713 title "Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir" @default.
• W2088105713 cites W1595811193 @default.
• W2088105713 cites W1976329877 @default.
• W2088105713 cites W1985255191 @default.
• W2088105713 cites W1990287212 @default.
• W2088105713 cites W2002280483 @default.
• W2088105713 cites W2005012167 @default.
• W2088105713 cites W2009684443 @default.
• W2088105713 cites W2032448658 @default.
• W2088105713 cites W2056937874 @default.
• W2088105713 cites W2071497196 @default.
• W2088105713 cites W2072626527 @default.
• W2088105713 cites W2084429573 @default.
• W2088105713 cites W2088466503 @default.
• W2088105713 cites W2095600505 @default.
• W2088105713 cites W2101127468 @default.
• W2088105713 cites W2124485554 @default.
• W2088105713 cites W2128672071 @default.
• W2088105713 cites W2132576204 @default.
• W2088105713 cites W2149248348 @default.
• W2088105713 cites W2154041910 @default.
• W2088105713 cites W2165600338 @default.
• W2088105713 doi "https://doi.org/10.1016/j.bbrc.2011.11.089" @default.
• W2088105713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3259256" @default.
• W2088105713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22142846" @default.
• W2088105713 hasPublicationYear "2012" @default.
• W2088105713 type Work @default.
• W2088105713 sameAs 2088105713 @default.
• W2088105713 citedByCount "47" @default.
• W2088105713 countsByYear W20881057132012 @default.
• W2088105713 countsByYear W20881057132013 @default.
• W2088105713 countsByYear W20881057132014 @default.
• W2088105713 countsByYear W20881057132015 @default.
• W2088105713 countsByYear W20881057132016 @default.
• W2088105713 countsByYear W20881057132017 @default.
• W2088105713 countsByYear W20881057132018 @default.
• W2088105713 countsByYear W20881057132019 @default.
• W2088105713 countsByYear W20881057132020 @default.
• W2088105713 countsByYear W20881057132021 @default.
• W2088105713 countsByYear W20881057132022 @default.
• W2088105713 countsByYear W20881057132023 @default.
• W2088105713 crossrefType "journal-article" @default.
• W2088105713 hasAuthorship W2088105713A5008731793 @default.
• W2088105713 hasAuthorship W2088105713A5044874669 @default.
• W2088105713 hasAuthorship W2088105713A5047150965 @default.
• W2088105713 hasAuthorship W2088105713A5069822390 @default.
• W2088105713 hasBestOaLocation W20881057132 @default.
• W2088105713 hasConcept C104317684 @default.
• W2088105713 hasConcept C127561419 @default.
• W2088105713 hasConcept C137620995 @default.
• W2088105713 hasConcept C142462285 @default.
• W2088105713 hasConcept C170320316 @default.
• W2088105713 hasConcept C170493617 @default.
• W2088105713 hasConcept C182819311 @default.
• W2088105713 hasConcept C185592680 @default.
• W2088105713 hasConcept C202751555 @default.
• W2088105713 hasConcept C203014093 @default.
• W2088105713 hasConcept C2522874641 @default.
• W2088105713 hasConcept C2776033226 @default.
• W2088105713 hasConcept C2778260815 @default.
• W2088105713 hasConcept C2779131293 @default.
• W2088105713 hasConcept C2779298103 @default.
• W2088105713 hasConcept C2780176071 @default.
• W2088105713 hasConcept C2993143319 @default.
• W2088105713 hasConcept C55493867 @default.
• W2088105713 hasConcept C62478195 @default.
• W2088105713 hasConcept C86803240 @default.
• W2088105713 hasConcept C95444343 @default.
• W2088105713 hasConceptScore W2088105713C104317684 @default.
• W2088105713 hasConceptScore W2088105713C127561419 @default.
• W2088105713 hasConceptScore W2088105713C137620995 @default.
• W2088105713 hasConceptScore W2088105713C142462285 @default.
• W2088105713 hasConceptScore W2088105713C170320316 @default.
• W2088105713 hasConceptScore W2088105713C170493617 @default.
• W2088105713 hasConceptScore W2088105713C182819311 @default.
• W2088105713 hasConceptScore W2088105713C185592680 @default.
• W2088105713 hasConceptScore W2088105713C202751555 @default.
• W2088105713 hasConceptScore W2088105713C203014093 @default.
• W2088105713 hasConceptScore W2088105713C2522874641 @default.
• W2088105713 hasConceptScore W2088105713C2776033226 @default.
• W2088105713 hasConceptScore W2088105713C2778260815 @default.
• W2088105713 hasConceptScore W2088105713C2779131293 @default.
• W2088105713 hasConceptScore W2088105713C2779298103 @default.
• W2088105713 hasConceptScore W2088105713C2780176071 @default.
• W2088105713 hasConceptScore W2088105713C2993143319 @default.
• W2088105713 hasConceptScore W2088105713C55493867 @default.
• W2088105713 hasConceptScore W2088105713C62478195 @default.
• W2088105713 hasConceptScore W2088105713C86803240 @default.
• W2088105713 hasConceptScore W2088105713C95444343 @default.
• W2088105713 hasFunder F4320332161 @default.

• next