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- W2088106896 abstract "Nicotinic acid, which has been shown to be a potent inhibitor of lipolysis in vitro (1), depresses plasma free fatty acid (FFA) levels in rats, dogs (2) and man (3,4). In each of these species the initial FFA depression is followed by a rise to markedly elevated concentrations (FFA rebound). Earlier studies in rats have demonstrated that the FFA rebound response is mediated by the pituitary-adrenal system (2). An increase in plasma corticosterone levels was associated with the rise in plasma FFA concentrations. Studies of the time course of changes in plasma FFA levels suggested the possibility that the rebound response and the elevated levels of corticosterone were evoked by the initial depression of plasma FFA concentrations. To investigate this possibility studies of the effects of a wide range of doses of nicotinic acid on plasma FFA and corticosterone levels were undertaken." @default.
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- W2088106896 date "1971-01-01" @default.
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- W2088106896 title "The biphasic effect of nicotinic acid on plasma FFA levels" @default.
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- W2088106896 doi "https://doi.org/10.1016/0024-3205(71)90240-2" @default.
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