FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088117005> ?p ?o ?g. }

• W2088117005 endingPage "69" @default.
• W2088117005 startingPage "64" @default.
• W2088117005 abstract "Ion channels are integral membrane proteins that control movement of ions into or out of cells. They are key components in a wide range of biological processes. Different types of ion channels have different biological functions. With the appearance of vast proteomic data, it is highly desirable for both basic research and drug–target discovery to develop a computational method for the reliable prediction of ion channels and their types. In this study, we developed a support vector machine-based method to predict ion channels and their types using primary sequence information. A feature selection technique, analysis of variance (ANOVA), was introduced to remove feature redundancy and find out an optimized feature set for improving predictive performance. Jackknife cross-validated results show that the proposed method can discriminate ion channels from non-ion channels with an overall accuracy of 86.6%, classify voltage-gated ion channels and ligand-gated ion channels with an overall accuracy of 92.6% and predict four types (potassium, sodium, calcium and anion) of voltage-gated ion channels with an overall accuracy of 87.8%, respectively. These results indicate that the proposed method can correctly identify ion channels and provide important instructions for drug–target discovery. The predictor can be freely downloaded from http://cobi.uestc.edu.cn/people/hlin/tools/IonchanPred/." @default.
• W2088117005 created "2016-06-24" @default.
• W2088117005 creator A5041539298 @default.
• W2088117005 creator A5062628676 @default.
• W2088117005 date "2011-01-01" @default.
• W2088117005 modified "2023-10-06" @default.
• W2088117005 title "Predicting ion channels and their types by the dipeptide mode of pseudo amino acid composition" @default.
• W2088117005 cites W171109620 @default.
• W2088117005 cites W1964077604 @default.
• W2088117005 cites W1967501922 @default.
• W2088117005 cites W1967888993 @default.
• W2088117005 cites W1968019678 @default.
• W2088117005 cites W1969766315 @default.
• W2088117005 cites W1972848687 @default.
• W2088117005 cites W1973253766 @default.
• W2088117005 cites W1976133477 @default.
• W2088117005 cites W1977927254 @default.
• W2088117005 cites W1978257492 @default.
• W2088117005 cites W1980256262 @default.
• W2088117005 cites W1980826656 @default.
• W2088117005 cites W1981091069 @default.
• W2088117005 cites W1982178440 @default.
• W2088117005 cites W1982276763 @default.
• W2088117005 cites W1992577925 @default.
• W2088117005 cites W1992991025 @default.
• W2088117005 cites W1995143646 @default.
• W2088117005 cites W2003613304 @default.
• W2088117005 cites W2008767404 @default.
• W2088117005 cites W2012686113 @default.
• W2088117005 cites W2013592650 @default.
• W2088117005 cites W2017277794 @default.
• W2088117005 cites W2018235493 @default.
• W2088117005 cites W2025577942 @default.
• W2088117005 cites W2029580264 @default.
• W2088117005 cites W2030634427 @default.
• W2088117005 cites W2033468519 @default.
• W2088117005 cites W2036154117 @default.
• W2088117005 cites W2036956828 @default.
• W2088117005 cites W2037831301 @default.
• W2088117005 cites W2040861514 @default.
• W2088117005 cites W2046691535 @default.
• W2088117005 cites W2048279801 @default.
• W2088117005 cites W2052932274 @default.
• W2088117005 cites W2053979203 @default.
• W2088117005 cites W2058557545 @default.
• W2088117005 cites W2061044370 @default.
• W2088117005 cites W2063030304 @default.
• W2088117005 cites W2068707634 @default.
• W2088117005 cites W2072294105 @default.
• W2088117005 cites W2076021406 @default.
• W2088117005 cites W2077799065 @default.
• W2088117005 cites W2080915318 @default.
• W2088117005 cites W2084242773 @default.
• W2088117005 cites W2087453953 @default.
• W2088117005 cites W2092616995 @default.
• W2088117005 cites W2092676806 @default.
• W2088117005 cites W2093577984 @default.
• W2088117005 cites W2099344204 @default.
• W2088117005 cites W2102354653 @default.
• W2088117005 cites W2105503585 @default.
• W2088117005 cites W2106386982 @default.
• W2088117005 cites W2114531694 @default.
• W2088117005 cites W2118101156 @default.
• W2088117005 cites W2120026469 @default.
• W2088117005 cites W2122181892 @default.
• W2088117005 cites W2132292391 @default.
• W2088117005 cites W2136228105 @default.
• W2088117005 cites W2138265290 @default.
• W2088117005 cites W2138441594 @default.
• W2088117005 cites W2143244636 @default.
• W2088117005 cites W2145957695 @default.
• W2088117005 cites W2146146101 @default.
• W2088117005 cites W2146773802 @default.
• W2088117005 cites W2149506965 @default.
• W2088117005 cites W2151000170 @default.
• W2088117005 cites W2151935677 @default.
• W2088117005 cites W2154053567 @default.
• W2088117005 cites W2156125289 @default.
• W2088117005 cites W2156168829 @default.
• W2088117005 cites W2160020195 @default.
• W2088117005 cites W2162132908 @default.
• W2088117005 cites W2163884975 @default.
• W2088117005 cites W2167635982 @default.
• W2088117005 cites W2169043568 @default.
• W2088117005 cites W4211000692 @default.
• W2088117005 doi "https://doi.org/10.1016/j.jtbi.2010.10.019" @default.
• W2088117005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20969879" @default.
• W2088117005 hasPublicationYear "2011" @default.
• W2088117005 type Work @default.
• W2088117005 sameAs 2088117005 @default.
• W2088117005 citedByCount "138" @default.
• W2088117005 countsByYear W20881170052012 @default.
• W2088117005 countsByYear W20881170052013 @default.
• W2088117005 countsByYear W20881170052014 @default.
• W2088117005 countsByYear W20881170052015 @default.
• W2088117005 countsByYear W20881170052016 @default.
• W2088117005 countsByYear W20881170052017 @default.
• W2088117005 countsByYear W20881170052018 @default.

• next