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- W2088121705 abstract "Forty three patients with lymphomas or chronic lymphocytic leukemia were treated with intravenous methyl ester of streptonigrin. The total dose for a single course ranged from 0.05 to 0.3 mg/kg, the optimum being 0.1 mg/kg. Thirty patients lived for at least 6 weeks and were considered evaluable. Nine objective remissions were seen in Hodgkin's disease, 5 in lymphocytic lymphoma, 2 in mycosis fungoides and 4 in chronic lymphocytic leukemia. The other 10 patients showed some evidence of favorable drug effect. Immediate toxic reactions were mainly nausea and emesis, though 3 patients had striking but reversible hypotension at the time the drug was administered. Thrombocytopenia occurred in 24 patients and leukopenia in 15 patients. Marrow suppression was generally reversible in 2 to 3 weeks." @default.
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- W2088121705 date "1966-10-01" @default.
- W2088121705 modified "2023-10-16" @default.
- W2088121705 title "Treatment of malignant lymphomas with methyl ester of streptonigrin (NSC 45384)" @default.
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- W2088121705 doi "https://doi.org/10.1002/1097-0142(196610)19:10<1377::aid-cncr2820191008>3.0.co;2-l" @default.
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