FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088134619> ?p ?o ?g. }

• W2088134619 endingPage "506" @default.
• W2088134619 startingPage "495" @default.
• W2088134619 abstract "Schwann cells contribute to efficient axonal regeneration after peripheral nerve injury and, when grafted to the central nervous system (CNS), also support a modest degree of central axonal regeneration. This study examined (1) whether Schwann cells grafted to the CNS exhibit normal patterns of differentiation and association with spinal axons and what signals putatively modulate these interactions, and (2) whether Schwann cells overexpressing neurotrophic factors enhance axonal regeneration. Thus, primary Schwann cells were transduced to hypersecrete human nerve growth factor (NGF) and were grafted to spinal cord injury sites in adult rats. Comparisons were made to nontransfected Schwann cells. From 3 days to 6 months later, grafted Schwann cells exhibited a phenotypic and temporal course of differentiation that matched patterns normally observed after peripheral nerve injury. Schwann cells spontaneously aligned into regular spatial arrays within the cord, appropriately remyelinated coerulospinal axons that regenerated into grafts, and appropriately ensheathed but did not myelinate sensory axons extending into grafts. Coordinate expression of the cell adhesion molecule L1 on Schwann cells and axons correlated with establishment of appropriate patterns of axon-Schwann cell ensheathment. Transduction of Schwann cells to overexpress NGF robustly increased axonal growth but did not otherwise alter the nature of interactions with growing axons. These findings suggest that signals expressed on Schwann cells that modulate peripheral axonal regeneration and myelination are also recognized in the CNS and that the modification of Schwann cells to overexpress growth factors significantly augments their capacity to support extensive axonal growth in models of CNS injury." @default.
• W2088134619 created "2016-06-24" @default.
• W2088134619 creator A5001684970 @default.
• W2088134619 creator A5004047617 @default.
• W2088134619 creator A5036494964 @default.
• W2088134619 creator A5055508729 @default.
• W2088134619 date "1999-11-01" @default.
• W2088134619 modified "2023-10-07" @default.
• W2088134619 title "Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1" @default.
• W2088134619 cites W123496385 @default.
• W2088134619 cites W1493358526 @default.
• W2088134619 cites W1566611926 @default.
• W2088134619 cites W1651777585 @default.
• W2088134619 cites W1906228984 @default.
• W2088134619 cites W1948129507 @default.
• W2088134619 cites W1965540256 @default.
• W2088134619 cites W1968815371 @default.
• W2088134619 cites W1970805231 @default.
• W2088134619 cites W1971451005 @default.
• W2088134619 cites W1977663196 @default.
• W2088134619 cites W1979510774 @default.
• W2088134619 cites W1980713523 @default.
• W2088134619 cites W1987699863 @default.
• W2088134619 cites W1988713855 @default.
• W2088134619 cites W1998059776 @default.
• W2088134619 cites W2009132635 @default.
• W2088134619 cites W2010124105 @default.
• W2088134619 cites W2013035816 @default.
• W2088134619 cites W2018747295 @default.
• W2088134619 cites W2034695173 @default.
• W2088134619 cites W2035995551 @default.
• W2088134619 cites W2037766842 @default.
• W2088134619 cites W2047945439 @default.
• W2088134619 cites W2053496651 @default.
• W2088134619 cites W2058785291 @default.
• W2088134619 cites W2071935688 @default.
• W2088134619 cites W2076397220 @default.
• W2088134619 cites W2083986625 @default.
• W2088134619 cites W2084141686 @default.
• W2088134619 cites W2085818575 @default.
• W2088134619 cites W2089382097 @default.
• W2088134619 cites W2089776797 @default.
• W2088134619 cites W2092722679 @default.
• W2088134619 cites W2102806552 @default.
• W2088134619 cites W2105197614 @default.
• W2088134619 cites W2112846844 @default.
• W2088134619 cites W2119409468 @default.
• W2088134619 cites W2128178775 @default.
• W2088134619 cites W2153842250 @default.
• W2088134619 cites W2170828389 @default.
• W2088134619 cites W2284201493 @default.
• W2088134619 cites W29868807 @default.
• W2088134619 cites W299374203 @default.
• W2088134619 cites W4206502174 @default.
• W2088134619 cites W4233046958 @default.
• W2088134619 cites W4248546713 @default.
• W2088134619 doi "https://doi.org/10.1002/(sici)1096-9861(19991101)413:4<495::aid-cne1>3.0.co;2-z" @default.
• W2088134619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10495438" @default.
• W2088134619 hasPublicationYear "1999" @default.
• W2088134619 type Work @default.
• W2088134619 sameAs 2088134619 @default.
• W2088134619 citedByCount "154" @default.
• W2088134619 countsByYear W20881346192012 @default.
• W2088134619 countsByYear W20881346192013 @default.
• W2088134619 countsByYear W20881346192014 @default.
• W2088134619 countsByYear W20881346192015 @default.
• W2088134619 countsByYear W20881346192016 @default.
• W2088134619 countsByYear W20881346192017 @default.
• W2088134619 countsByYear W20881346192018 @default.
• W2088134619 countsByYear W20881346192019 @default.
• W2088134619 countsByYear W20881346192020 @default.
• W2088134619 countsByYear W20881346192021 @default.
• W2088134619 countsByYear W20881346192022 @default.
• W2088134619 crossrefType "journal-article" @default.
• W2088134619 hasAuthorship W2088134619A5001684970 @default.
• W2088134619 hasAuthorship W2088134619A5004047617 @default.
• W2088134619 hasAuthorship W2088134619A5036494964 @default.
• W2088134619 hasAuthorship W2088134619A5055508729 @default.
• W2088134619 hasConcept C105702510 @default.
• W2088134619 hasConcept C136940099 @default.
• W2088134619 hasConcept C160539049 @default.
• W2088134619 hasConcept C169760540 @default.
• W2088134619 hasConcept C170493617 @default.
• W2088134619 hasConcept C171056886 @default.
• W2088134619 hasConcept C2777004073 @default.
• W2088134619 hasConcept C2778334475 @default.
• W2088134619 hasConcept C2778423431 @default.
• W2088134619 hasConcept C2779530196 @default.
• W2088134619 hasConcept C2780775167 @default.
• W2088134619 hasConcept C529278444 @default.
• W2088134619 hasConcept C545314008 @default.
• W2088134619 hasConcept C55493867 @default.
• W2088134619 hasConcept C86803240 @default.
• W2088134619 hasConcept C95444343 @default.
• W2088134619 hasConceptScore W2088134619C105702510 @default.
• W2088134619 hasConceptScore W2088134619C136940099 @default.
• W2088134619 hasConceptScore W2088134619C160539049 @default.
• W2088134619 hasConceptScore W2088134619C169760540 @default.

• next