Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088147598> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2088147598 endingPage "547" @default.
- W2088147598 startingPage "544" @default.
- W2088147598 abstract "Methotrexate, a mainstay treatment for children with acute lymphoblastic leukaemia, can cause neurotoxicity, with paralysis, seizures, somnolence, anorexia, and headaches. The pathophysiology of this reaction is unknown. It has been suggested that the anti-inflammatory effect of methotrexate in patients with arthritis is due to adenosine release brought on by inhibition of purine synthesis. Since adenosine is a central nervous system depressant, we wondered whether adenosine release in the central nervous system could account for some of the neurotoxicity due to methotrexate, and whether that toxicity could be lessened by displacement of adenosine from its receptor by aminophylline. 6 patients (age 3-16 years) who had methotrexate-induced neurotoxicity unresponsive to standard treatment received 2.5 mg/kg aminophylline. In addition, the concentration of adenosine in the cerebrospinal fluid (CSF) from 11 children completing a 24-h systemic methotrexate protocol was compared with that in 8 newly diagnosed patients and 12 who had not received any treatment for at least a week. 4 of 6 patients with toxic signs and symptoms attributed to methotrexate and unrelieved by steroids, epidural blood patch, promethazine, 5-hydroytryptamine antagonists, paracetamol, and narcotics, had complete resolution of neurotoxicity after or during a 1-h infusion of aminophylline; 2 others had a pronounced improvement but persistent nausea. CSF adenosine concentrations of patients receiving methotrexate, even when there was very slight or no toxicity, were greatly increased compared with control subjects (mean values of 217 and 51 nmol/L, median 175 and 52 nmol/L). Subacute methotrexate neurotoxicity may be mediated by adenosine and relieved by aminophylline." @default.
- W2088147598 created "2016-06-24" @default.
- W2088147598 creator A5007161606 @default.
- W2088147598 creator A5012277409 @default.
- W2088147598 creator A5012328118 @default.
- W2088147598 creator A5017293968 @default.
- W2088147598 creator A5044373932 @default.
- W2088147598 creator A5077925485 @default.
- W2088147598 date "1995-03-01" @default.
- W2088147598 modified "2023-09-27" @default.
- W2088147598 title "Aminophylline for methotrexate-induced neurotoxicity" @default.
- W2088147598 cites W1538643202 @default.
- W2088147598 cites W1828655749 @default.
- W2088147598 cites W1968274099 @default.
- W2088147598 cites W1999086038 @default.
- W2088147598 cites W2015138084 @default.
- W2088147598 cites W2023688534 @default.
- W2088147598 cites W2047861739 @default.
- W2088147598 cites W2051252465 @default.
- W2088147598 cites W2061393018 @default.
- W2088147598 cites W2061524947 @default.
- W2088147598 cites W2067043155 @default.
- W2088147598 cites W2090099318 @default.
- W2088147598 cites W2096864094 @default.
- W2088147598 cites W2120875709 @default.
- W2088147598 cites W2157940881 @default.
- W2088147598 cites W2160877509 @default.
- W2088147598 cites W2163770333 @default.
- W2088147598 cites W2200950976 @default.
- W2088147598 cites W2258754807 @default.
- W2088147598 cites W2264626034 @default.
- W2088147598 cites W2330069154 @default.
- W2088147598 cites W2339823575 @default.
- W2088147598 doi "https://doi.org/10.1016/s0140-6736(95)90464-6" @default.
- W2088147598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7776773" @default.
- W2088147598 hasPublicationYear "1995" @default.
- W2088147598 type Work @default.
- W2088147598 sameAs 2088147598 @default.
- W2088147598 citedByCount "143" @default.
- W2088147598 countsByYear W20881475982012 @default.
- W2088147598 countsByYear W20881475982013 @default.
- W2088147598 countsByYear W20881475982014 @default.
- W2088147598 countsByYear W20881475982015 @default.
- W2088147598 countsByYear W20881475982016 @default.
- W2088147598 countsByYear W20881475982017 @default.
- W2088147598 countsByYear W20881475982018 @default.
- W2088147598 countsByYear W20881475982019 @default.
- W2088147598 countsByYear W20881475982020 @default.
- W2088147598 countsByYear W20881475982021 @default.
- W2088147598 countsByYear W20881475982022 @default.
- W2088147598 countsByYear W20881475982023 @default.
- W2088147598 crossrefType "journal-article" @default.
- W2088147598 hasAuthorship W2088147598A5007161606 @default.
- W2088147598 hasAuthorship W2088147598A5012277409 @default.
- W2088147598 hasAuthorship W2088147598A5012328118 @default.
- W2088147598 hasAuthorship W2088147598A5017293968 @default.
- W2088147598 hasAuthorship W2088147598A5044373932 @default.
- W2088147598 hasAuthorship W2088147598A5077925485 @default.
- W2088147598 hasConcept C126322002 @default.
- W2088147598 hasConcept C2776202631 @default.
- W2088147598 hasConcept C2776991684 @default.
- W2088147598 hasConcept C2779491297 @default.
- W2088147598 hasConcept C2781059491 @default.
- W2088147598 hasConcept C29730261 @default.
- W2088147598 hasConcept C42219234 @default.
- W2088147598 hasConcept C71924100 @default.
- W2088147598 hasConcept C98274493 @default.
- W2088147598 hasConceptScore W2088147598C126322002 @default.
- W2088147598 hasConceptScore W2088147598C2776202631 @default.
- W2088147598 hasConceptScore W2088147598C2776991684 @default.
- W2088147598 hasConceptScore W2088147598C2779491297 @default.
- W2088147598 hasConceptScore W2088147598C2781059491 @default.
- W2088147598 hasConceptScore W2088147598C29730261 @default.
- W2088147598 hasConceptScore W2088147598C42219234 @default.
- W2088147598 hasConceptScore W2088147598C71924100 @default.
- W2088147598 hasConceptScore W2088147598C98274493 @default.
- W2088147598 hasIssue "8949" @default.
- W2088147598 hasLocation W20881475981 @default.
- W2088147598 hasLocation W20881475982 @default.
- W2088147598 hasOpenAccess W2088147598 @default.
- W2088147598 hasPrimaryLocation W20881475981 @default.
- W2088147598 hasRelatedWork W2000981677 @default.
- W2088147598 hasRelatedWork W2080775297 @default.
- W2088147598 hasRelatedWork W2080815447 @default.
- W2088147598 hasRelatedWork W2088367065 @default.
- W2088147598 hasRelatedWork W2214114704 @default.
- W2088147598 hasRelatedWork W2403661347 @default.
- W2088147598 hasRelatedWork W2434055052 @default.
- W2088147598 hasRelatedWork W2439261794 @default.
- W2088147598 hasRelatedWork W2463173140 @default.
- W2088147598 hasRelatedWork W2905944378 @default.
- W2088147598 hasVolume "345" @default.
- W2088147598 isParatext "false" @default.
- W2088147598 isRetracted "false" @default.
- W2088147598 magId "2088147598" @default.
- W2088147598 workType "article" @default.