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- W2088156716 abstract "As the major enamel matrix protein contributing to tooth development, amelogenin has been demonstrated to play a crucial role in tooth enamel formation. Previous studies have revealed amelogenin alternative splicing as a mechanism for amelogenin heterogeneous expression in mammals. While amelogenin and its splicing forms in mammalian vertebrates have been characterized, splicing variants of amelogenin gene still remains largely unknown in non-mammalian species. Here, using PCR and sequence analysis we discovered two novel amelogenin transcript variants in tooth organ extracts from a caudate amphibian, the salamander Plethodoncinereus. The one was shorter -S- (416 nucleotides including untranslated regions, 5 exons) and the other larger -L- (851 nt, 7 exons) than the previously published normal gene in this species -M- (812 nucleotides, 6 exons). This is the first report demonstrating the amelogenin alternative splicing in amphibian, revealing a unique exon 2b and two novel amelogenin gene transcripts in Plethodoncinereus." @default.
- W2088156716 created "2016-06-24" @default.
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- W2088156716 date "2013-06-26" @default.
- W2088156716 modified "2023-10-18" @default.
- W2088156716 title "Alternative Splicing of the Amelogenin Gene in a Caudate Amphibian, Plethodon cinereus" @default.
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- W2088156716 doi "https://doi.org/10.1371/journal.pone.0068965" @default.
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