FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088156972> ?p ?o ?g. }

• W2088156972 endingPage "1401" @default.
• W2088156972 startingPage "1395" @default.
• W2088156972 abstract "The 72-kd type IV collagenase (matrix metalloproteinase-2 [MMP-2]) is a neutral metalloproteinase that initiates the degradation of type IV collagen in basement membranes. Its production by tumor cells has been correlated with the invasive and metastatic potential of neoplasms. Two recently developed affinity-purified antibodies against synthetic peptides from the amino terminus (H1) and an internal domain (Ab48) of the molecule were used to investigate immunohistochemically the distribution of this enzyme in a variety of thyroid tissues. All primary carcinomas (20 papillary, seven follicular, and three medullary) as well as nine of 11 metastases were positive, with the more aggressive tumors (tall cell variant of papillary carcinomas and invasive follicular carcinomas) tending to be more reactive than the low-grade tumors (classic and microinvasive papillary carcinomas and minimally invasive follicular tumors). Negative or minimal positivity was found in six cases of normal thyroid, one goiter, and two cases of Graves' disease. Immunoreactive follicular cells were seen focally in areas of inflammation, fibrosis, and distortion of normal follicles, and in Hashimoto's thyroiditis (four cases). Five of nine adenomas showed positive cells, but this could be related to previous trauma to the area. We conclude that there is increased production of the 72-kd type IV collagenase (MMP-2) in thyroid cancer; however, this enzyme also is elevated in benign conditions that are undergoing remodeling and repair." @default.
• W2088156972 created "2016-06-24" @default.
• W2088156972 creator A5024598099 @default.
• W2088156972 creator A5056579080 @default.
• W2088156972 creator A5059097260 @default.
• W2088156972 creator A5086886026 @default.
• W2088156972 creator A5091380477 @default.
• W2088156972 date "1992-12-01" @default.
• W2088156972 modified "2023-09-26" @default.
• W2088156972 title "Distribution of the 72-kd type IV collagenase in nonneoplastic and neoplastic thyroid tissue" @default.
• W2088156972 cites W1534999453 @default.
• W2088156972 cites W1583304743 @default.
• W2088156972 cites W1602004990 @default.
• W2088156972 cites W1607177112 @default.
• W2088156972 cites W1664158328 @default.
• W2088156972 cites W1970240053 @default.
• W2088156972 cites W1978476901 @default.
• W2088156972 cites W1984396998 @default.
• W2088156972 cites W1990035139 @default.
• W2088156972 cites W1990440707 @default.
• W2088156972 cites W1993715195 @default.
• W2088156972 cites W1995249913 @default.
• W2088156972 cites W2017812744 @default.
• W2088156972 cites W2021020602 @default.
• W2088156972 cites W2038637551 @default.
• W2088156972 cites W2055333277 @default.
• W2088156972 cites W2073462527 @default.
• W2088156972 cites W2082487528 @default.
• W2088156972 cites W2091585840 @default.
• W2088156972 cites W2096428903 @default.
• W2088156972 cites W2107237937 @default.
• W2088156972 cites W2114341924 @default.
• W2088156972 cites W2161793121 @default.
• W2088156972 cites W2323027060 @default.
• W2088156972 cites W81204267 @default.
• W2088156972 doi "https://doi.org/10.1016/0046-8177(92)90060-g" @default.
• W2088156972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1468777" @default.
• W2088156972 hasPublicationYear "1992" @default.
• W2088156972 type Work @default.
• W2088156972 sameAs 2088156972 @default.
• W2088156972 citedByCount "113" @default.
• W2088156972 countsByYear W20881569722012 @default.
• W2088156972 countsByYear W20881569722013 @default.
• W2088156972 countsByYear W20881569722014 @default.
• W2088156972 countsByYear W20881569722015 @default.
• W2088156972 countsByYear W20881569722016 @default.
• W2088156972 countsByYear W20881569722017 @default.
• W2088156972 countsByYear W20881569722018 @default.
• W2088156972 countsByYear W20881569722020 @default.
• W2088156972 countsByYear W20881569722021 @default.
• W2088156972 countsByYear W20881569722022 @default.
• W2088156972 crossrefType "journal-article" @default.
• W2088156972 hasAuthorship W2088156972A5024598099 @default.
• W2088156972 hasAuthorship W2088156972A5056579080 @default.
• W2088156972 hasAuthorship W2088156972A5059097260 @default.
• W2088156972 hasAuthorship W2088156972A5086886026 @default.
• W2088156972 hasAuthorship W2088156972A5091380477 @default.
• W2088156972 hasConcept C109523444 @default.
• W2088156972 hasConcept C126322002 @default.
• W2088156972 hasConcept C142724271 @default.
• W2088156972 hasConcept C181199279 @default.
• W2088156972 hasConcept C185592680 @default.
• W2088156972 hasConcept C187785154 @default.
• W2088156972 hasConcept C2776193487 @default.
• W2088156972 hasConcept C2776254400 @default.
• W2088156972 hasConcept C2778394429 @default.
• W2088156972 hasConcept C2778696486 @default.
• W2088156972 hasConcept C2780559512 @default.
• W2088156972 hasConcept C2993294228 @default.
• W2088156972 hasConcept C526584372 @default.
• W2088156972 hasConcept C55493867 @default.
• W2088156972 hasConcept C71924100 @default.
• W2088156972 hasConceptScore W2088156972C109523444 @default.
• W2088156972 hasConceptScore W2088156972C126322002 @default.
• W2088156972 hasConceptScore W2088156972C142724271 @default.
• W2088156972 hasConceptScore W2088156972C181199279 @default.
• W2088156972 hasConceptScore W2088156972C185592680 @default.
• W2088156972 hasConceptScore W2088156972C187785154 @default.
• W2088156972 hasConceptScore W2088156972C2776193487 @default.
• W2088156972 hasConceptScore W2088156972C2776254400 @default.
• W2088156972 hasConceptScore W2088156972C2778394429 @default.
• W2088156972 hasConceptScore W2088156972C2778696486 @default.
• W2088156972 hasConceptScore W2088156972C2780559512 @default.
• W2088156972 hasConceptScore W2088156972C2993294228 @default.
• W2088156972 hasConceptScore W2088156972C526584372 @default.
• W2088156972 hasConceptScore W2088156972C55493867 @default.
• W2088156972 hasConceptScore W2088156972C71924100 @default.
• W2088156972 hasIssue "12" @default.
• W2088156972 hasLocation W20881569721 @default.
• W2088156972 hasLocation W20881569722 @default.
• W2088156972 hasOpenAccess W2088156972 @default.
• W2088156972 hasPrimaryLocation W20881569721 @default.
• W2088156972 hasRelatedWork W1883339594 @default.
• W2088156972 hasRelatedWork W1971665675 @default.
• W2088156972 hasRelatedWork W1977015747 @default.
• W2088156972 hasRelatedWork W1992191048 @default.
• W2088156972 hasRelatedWork W2019930929 @default.
• W2088156972 hasRelatedWork W2341815647 @default.

• next