Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088162468> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2088162468 endingPage "23" @default.
- W2088162468 startingPage "1" @default.
- W2088162468 abstract "We studied the pharmacokinetics, biodistribution and metabolism of phospho-sulindac (PS), a novel agent efficacious in the treatment of dry eye, formulated in nanoparticles (PS-NPs) following its topical administration to the eye of New Zealand White rabbits. The nanoparticles were spherical with effective diameter = 108.9 ± 41.7 nm, zeta potential = −21.70 ± 3.78 mV, drug loading = 7%, and entrapment efficiency = 46.4%. Of the total PS delivered topically to the eye, >95% was retained in the anterior segment, predominantly in the cornea (Cmax = 101.3 μM; Tmax = 1 h; T1/2 = 2.6 h; area AUC0–16h = 164.4 µM·h) and conjunctiva (Cmax = 89.4 μM; Tmax = 0.25 h; T1/2 = 3.1 h; AUC0–16h = 63.5 µM·h), the tissues most affected by dry eye disease. No PS or its metabolites were detected in the systemic circulation. PS was metabolized to PS sulfide and PS sulfone; all three molecules were hydrolyzed to sulindac, which was converted to sulindac sulfide and sulindac sulfone. A solution formulation of PS provided lower PS levels in ocular tissues but higher levels of PS metabolites, compared to PS-NPs. Therefore, NPs represent an effective formulation for the topical ocular administration of PS for anterior segment diseases, such as dry eye disease." @default.
- W2088162468 created "2016-06-24" @default.
- W2088162468 creator A5060808445 @default.
- W2088162468 creator A5067506411 @default.
- W2088162468 date "2003-02-01" @default.
- W2088162468 modified "2023-10-01" @default.
- W2088162468 title "Anatomy, development, and physiology of the visual system" @default.
- W2088162468 cites W1561801626 @default.
- W2088162468 cites W1969310811 @default.
- W2088162468 cites W1978673893 @default.
- W2088162468 cites W1981142105 @default.
- W2088162468 cites W1981747116 @default.
- W2088162468 cites W2011335970 @default.
- W2088162468 cites W2026208796 @default.
- W2088162468 cites W2030520178 @default.
- W2088162468 cites W2035913375 @default.
- W2088162468 cites W2040951115 @default.
- W2088162468 cites W2048201103 @default.
- W2088162468 cites W2056077890 @default.
- W2088162468 cites W2066911117 @default.
- W2088162468 cites W2069084189 @default.
- W2088162468 cites W2074274620 @default.
- W2088162468 cites W2085475452 @default.
- W2088162468 cites W2090922624 @default.
- W2088162468 cites W2131365964 @default.
- W2088162468 cites W2136157305 @default.
- W2088162468 cites W2142971391 @default.
- W2088162468 cites W4243915831 @default.
- W2088162468 cites W4251735674 @default.
- W2088162468 doi "https://doi.org/10.1016/s0031-3955(02)00132-3" @default.
- W2088162468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12713101" @default.
- W2088162468 hasPublicationYear "2003" @default.
- W2088162468 type Work @default.
- W2088162468 sameAs 2088162468 @default.
- W2088162468 citedByCount "29" @default.
- W2088162468 countsByYear W20881624682013 @default.
- W2088162468 countsByYear W20881624682014 @default.
- W2088162468 countsByYear W20881624682015 @default.
- W2088162468 countsByYear W20881624682017 @default.
- W2088162468 countsByYear W20881624682019 @default.
- W2088162468 countsByYear W20881624682021 @default.
- W2088162468 countsByYear W20881624682022 @default.
- W2088162468 countsByYear W20881624682023 @default.
- W2088162468 crossrefType "journal-article" @default.
- W2088162468 hasAuthorship W2088162468A5060808445 @default.
- W2088162468 hasAuthorship W2088162468A5067506411 @default.
- W2088162468 hasConcept C112705442 @default.
- W2088162468 hasConcept C118487528 @default.
- W2088162468 hasConcept C134018914 @default.
- W2088162468 hasConcept C181389837 @default.
- W2088162468 hasConcept C185592680 @default.
- W2088162468 hasConcept C202751555 @default.
- W2088162468 hasConcept C22979827 @default.
- W2088162468 hasConcept C2776241388 @default.
- W2088162468 hasConcept C2776882836 @default.
- W2088162468 hasConcept C2777477808 @default.
- W2088162468 hasConcept C2777807558 @default.
- W2088162468 hasConcept C2778484676 @default.
- W2088162468 hasConcept C55493867 @default.
- W2088162468 hasConcept C71924100 @default.
- W2088162468 hasConcept C98274493 @default.
- W2088162468 hasConceptScore W2088162468C112705442 @default.
- W2088162468 hasConceptScore W2088162468C118487528 @default.
- W2088162468 hasConceptScore W2088162468C134018914 @default.
- W2088162468 hasConceptScore W2088162468C181389837 @default.
- W2088162468 hasConceptScore W2088162468C185592680 @default.
- W2088162468 hasConceptScore W2088162468C202751555 @default.
- W2088162468 hasConceptScore W2088162468C22979827 @default.
- W2088162468 hasConceptScore W2088162468C2776241388 @default.
- W2088162468 hasConceptScore W2088162468C2776882836 @default.
- W2088162468 hasConceptScore W2088162468C2777477808 @default.
- W2088162468 hasConceptScore W2088162468C2777807558 @default.
- W2088162468 hasConceptScore W2088162468C2778484676 @default.
- W2088162468 hasConceptScore W2088162468C55493867 @default.
- W2088162468 hasConceptScore W2088162468C71924100 @default.
- W2088162468 hasConceptScore W2088162468C98274493 @default.
- W2088162468 hasIssue "1" @default.
- W2088162468 hasLocation W20881624681 @default.
- W2088162468 hasLocation W20881624682 @default.
- W2088162468 hasOpenAccess W2088162468 @default.
- W2088162468 hasPrimaryLocation W20881624681 @default.
- W2088162468 hasRelatedWork W1969574919 @default.
- W2088162468 hasRelatedWork W2030240071 @default.
- W2088162468 hasRelatedWork W2033151 @default.
- W2088162468 hasRelatedWork W2049403898 @default.
- W2088162468 hasRelatedWork W2056938528 @default.
- W2088162468 hasRelatedWork W2068318921 @default.
- W2088162468 hasRelatedWork W2080955156 @default.
- W2088162468 hasRelatedWork W2373237830 @default.
- W2088162468 hasRelatedWork W2587902810 @default.
- W2088162468 hasRelatedWork W4281257348 @default.
- W2088162468 hasVolume "50" @default.
- W2088162468 isParatext "false" @default.
- W2088162468 isRetracted "false" @default.
- W2088162468 magId "2088162468" @default.
- W2088162468 workType "article" @default.