FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088164987> ?p ?o ?g. }

• W2088164987 abstract "Propofol is a commonly used general anesthetic agent which has been previously shown to enhance the inhibitory GABAergic transmission in the central nervous system. In addition to the GABAergic element, the excitatory transmission may be another central molecular site impacted by propofol. Increasing evidence implies that the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor represents an excitatory amino acid receptor subtype subjected to the regulation by propofol. Indeed, in this study, we found that a single injection of propofol at an anesthetic dose increased AMPA receptor GluA1 subunit phosphorylation in young (2-3 months old) and aged (20-21 months old) mice in vivo. Propofol caused an increase in GluA1 phosphorylation in the hippocampus but not in the prefrontal cortex. The propofol effect was also site-selective as the drug elevated GluA1 phosphorylation at serine 831 (S831) but not serine 845. Interestingly, while propofol induced a moderate and transient increase in S831 phosphorylation in young mice, the drug caused a substantial and sustained S831 phosphorylation in aged animals. Total GluA1 abundance remained stable in the hippocampus and prefrontal cortex in both young and aged mice in response to propofol. These results provide evidence supporting the sensitivity of GluA1 AMPA receptors to propofol. A single dose of propofol was able to upregulate GluA1 phosphorylation in the confined hippocampus in an age-dependent manner." @default.
• W2088164987 created "2016-06-24" @default.
• W2088164987 creator A5043622724 @default.
• W2088164987 creator A5049821571 @default.
• W2088164987 creator A5069926062 @default.
• W2088164987 creator A5086719486 @default.
• W2088164987 date "2014-09-01" @default.
• W2088164987 modified "2023-09-22" @default.
• W2088164987 title "Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice" @default.
• W2088164987 cites W1579839296 @default.
• W2088164987 cites W1965400901 @default.
• W2088164987 cites W1969895093 @default.
• W2088164987 cites W197691482 @default.
• W2088164987 cites W1977507283 @default.
• W2088164987 cites W1978155331 @default.
• W2088164987 cites W1982912361 @default.
• W2088164987 cites W1983252720 @default.
• W2088164987 cites W1986789637 @default.
• W2088164987 cites W1987468578 @default.
• W2088164987 cites W1991789257 @default.
• W2088164987 cites W1993135690 @default.
• W2088164987 cites W2014596089 @default.
• W2088164987 cites W2019035666 @default.
• W2088164987 cites W2023894581 @default.
• W2088164987 cites W2024207015 @default.
• W2088164987 cites W2026817996 @default.
• W2088164987 cites W2037852973 @default.
• W2088164987 cites W2045565980 @default.
• W2088164987 cites W2045780885 @default.
• W2088164987 cites W2047470842 @default.
• W2088164987 cites W2051710103 @default.
• W2088164987 cites W2058109462 @default.
• W2088164987 cites W2058185503 @default.
• W2088164987 cites W2063509404 @default.
• W2088164987 cites W2073585436 @default.
• W2088164987 cites W2080210728 @default.
• W2088164987 cites W2081025398 @default.
• W2088164987 cites W2086494545 @default.
• W2088164987 cites W2092273976 @default.
• W2088164987 cites W2092589787 @default.
• W2088164987 cites W2100231995 @default.
• W2088164987 cites W2106828113 @default.
• W2088164987 cites W2108050717 @default.
• W2088164987 cites W2110802266 @default.
• W2088164987 cites W2118549143 @default.
• W2088164987 cites W2122473696 @default.
• W2088164987 cites W2145437687 @default.
• W2088164987 cites W2145822280 @default.
• W2088164987 cites W2146375752 @default.
• W2088164987 cites W2149594094 @default.
• W2088164987 cites W2156427101 @default.
• W2088164987 cites W2161036636 @default.
• W2088164987 cites W2162552344 @default.
• W2088164987 cites W2165120030 @default.
• W2088164987 cites W2165483780 @default.
• W2088164987 cites W2166990495 @default.
• W2088164987 cites W2168132039 @default.
• W2088164987 cites W2170310896 @default.
• W2088164987 cites W2170532212 @default.
• W2088164987 cites W2471491982 @default.
• W2088164987 doi "https://doi.org/10.1016/j.ejphar.2014.05.053" @default.
• W2088164987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4114233" @default.
• W2088164987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24907515" @default.
• W2088164987 hasPublicationYear "2014" @default.
• W2088164987 type Work @default.
• W2088164987 sameAs 2088164987 @default.
• W2088164987 citedByCount "2" @default.
• W2088164987 countsByYear W20881649872015 @default.
• W2088164987 countsByYear W20881649872021 @default.
• W2088164987 crossrefType "journal-article" @default.
• W2088164987 hasAuthorship W2088164987A5043622724 @default.
• W2088164987 hasAuthorship W2088164987A5049821571 @default.
• W2088164987 hasAuthorship W2088164987A5069926062 @default.
• W2088164987 hasAuthorship W2088164987A5086719486 @default.
• W2088164987 hasBestOaLocation W20881649872 @default.
• W2088164987 hasConcept C112592302 @default.
• W2088164987 hasConcept C11960822 @default.
• W2088164987 hasConcept C126322002 @default.
• W2088164987 hasConcept C134018914 @default.
• W2088164987 hasConcept C160268369 @default.
• W2088164987 hasConcept C169760540 @default.
• W2088164987 hasConcept C169900460 @default.
• W2088164987 hasConcept C170493617 @default.
• W2088164987 hasConcept C17077164 @default.
• W2088164987 hasConcept C185592680 @default.
• W2088164987 hasConcept C2776277131 @default.
• W2088164987 hasConcept C2779177108 @default.
• W2088164987 hasConcept C2781161787 @default.
• W2088164987 hasConcept C2781195155 @default.
• W2088164987 hasConcept C61174792 @default.
• W2088164987 hasConcept C71924100 @default.
• W2088164987 hasConcept C86803240 @default.
• W2088164987 hasConcept C95444343 @default.
• W2088164987 hasConcept C98274493 @default.
• W2088164987 hasConceptScore W2088164987C112592302 @default.
• W2088164987 hasConceptScore W2088164987C11960822 @default.
• W2088164987 hasConceptScore W2088164987C126322002 @default.
• W2088164987 hasConceptScore W2088164987C134018914 @default.
• W2088164987 hasConceptScore W2088164987C160268369 @default.
• W2088164987 hasConceptScore W2088164987C169760540 @default.

• next