Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088165738> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2088165738 abstract "Respiratory distress syndrome, resulting from the deficiency of endogenous surfactant, remains a leading cause of mortality and morbidity in preterm infants. Exogenous surfactant replacement therapy is one of the most widely researched areas in neonatal medicine and is now accepted as the standard of care for preventing and treating respiratory distress syndrome in these newborns. Exogenous surfactant replacement therapy has evolved in the past three decades, but controversies still exist as to the choice of preparation (i.e., is one better than the others?), dosing and volume of individual preparations, and cost. At present, animal-derived surfactants that contain proteins appear to be the choice of most clinicians; however, they may have the limitation of being derived from animal sources. This has prompted the development of newer synthetic surfactants such as lucinactant (Surfaxin™, Discovery Laboratories, PA, USA), which contains the protein B mimic synthetic peptide, sinapultide. Although it is not yet commercially available or approved for clinical use by regulatory authorities, recent Phase III clinical trials with lucinactant demonstrated promising results with similar efficacy to animal-derived surfactants whilst avoiding the disadvantage associated with animal products. The availability of such a surfactant in large amounts at a relatively lower production cost should also prompt further investigations regarding expanded use of surfactants in conditions other than neonatal respiratory distress syndrome, such as meconium aspiration syndromes and pneumonia, and as a vehicle for administering drugs directly to the lungs. There are also some developments towards making aerosolized forms of surfactant, which could be administered noninvasively, thus obviating the need for endotracheal intubation and its associated complications. The purpose of this article is to provide an appraisal of the recent advances in surfactant replacement therapy and its future developments." @default.
- W2088165738 created "2016-06-24" @default.
- W2088165738 creator A5016652252 @default.
- W2088165738 creator A5041853225 @default.
- W2088165738 date "2009-10-01" @default.
- W2088165738 modified "2023-09-26" @default.
- W2088165738 title "Lucinactant (Surfaxin™) for prevention and treatment of respiratory distress syndrome in newborns" @default.
- W2088165738 cites W1988390928 @default.
- W2088165738 cites W1995419725 @default.
- W2088165738 cites W1996682753 @default.
- W2088165738 cites W2006465225 @default.
- W2088165738 cites W2010158544 @default.
- W2088165738 cites W2015899239 @default.
- W2088165738 cites W2020236767 @default.
- W2088165738 cites W2042028931 @default.
- W2088165738 cites W2086067732 @default.
- W2088165738 cites W2101595291 @default.
- W2088165738 cites W2127352951 @default.
- W2088165738 cites W2132448456 @default.
- W2088165738 cites W2149883421 @default.
- W2088165738 cites W2149985735 @default.
- W2088165738 cites W2903859633 @default.
- W2088165738 cites W3021353032 @default.
- W2088165738 cites W4234614979 @default.
- W2088165738 cites W4238246092 @default.
- W2088165738 cites W2129596517 @default.
- W2088165738 doi "https://doi.org/10.2217/phe.09.49" @default.
- W2088165738 hasPublicationYear "2009" @default.
- W2088165738 type Work @default.
- W2088165738 sameAs 2088165738 @default.
- W2088165738 citedByCount "2" @default.
- W2088165738 countsByYear W20881657382020 @default.
- W2088165738 crossrefType "journal-article" @default.
- W2088165738 hasAuthorship W2088165738A5016652252 @default.
- W2088165738 hasAuthorship W2088165738A5041853225 @default.
- W2088165738 hasConcept C126322002 @default.
- W2088165738 hasConcept C141071460 @default.
- W2088165738 hasConcept C141983124 @default.
- W2088165738 hasConcept C177713679 @default.
- W2088165738 hasConcept C187212893 @default.
- W2088165738 hasConcept C2777288759 @default.
- W2088165738 hasConcept C2778376644 @default.
- W2088165738 hasConcept C2779234561 @default.
- W2088165738 hasConcept C2780395437 @default.
- W2088165738 hasConcept C54355233 @default.
- W2088165738 hasConcept C55493867 @default.
- W2088165738 hasConcept C58226133 @default.
- W2088165738 hasConcept C71924100 @default.
- W2088165738 hasConcept C86803240 @default.
- W2088165738 hasConceptScore W2088165738C126322002 @default.
- W2088165738 hasConceptScore W2088165738C141071460 @default.
- W2088165738 hasConceptScore W2088165738C141983124 @default.
- W2088165738 hasConceptScore W2088165738C177713679 @default.
- W2088165738 hasConceptScore W2088165738C187212893 @default.
- W2088165738 hasConceptScore W2088165738C2777288759 @default.
- W2088165738 hasConceptScore W2088165738C2778376644 @default.
- W2088165738 hasConceptScore W2088165738C2779234561 @default.
- W2088165738 hasConceptScore W2088165738C2780395437 @default.
- W2088165738 hasConceptScore W2088165738C54355233 @default.
- W2088165738 hasConceptScore W2088165738C55493867 @default.
- W2088165738 hasConceptScore W2088165738C58226133 @default.
- W2088165738 hasConceptScore W2088165738C71924100 @default.
- W2088165738 hasConceptScore W2088165738C86803240 @default.
- W2088165738 hasLocation W20881657381 @default.
- W2088165738 hasOpenAccess W2088165738 @default.
- W2088165738 hasPrimaryLocation W20881657381 @default.
- W2088165738 hasRelatedWork W1520469746 @default.
- W2088165738 hasRelatedWork W1539705221 @default.
- W2088165738 hasRelatedWork W1935221637 @default.
- W2088165738 hasRelatedWork W1982589376 @default.
- W2088165738 hasRelatedWork W1991235040 @default.
- W2088165738 hasRelatedWork W2042851369 @default.
- W2088165738 hasRelatedWork W2048518028 @default.
- W2088165738 hasRelatedWork W2049701596 @default.
- W2088165738 hasRelatedWork W2085183303 @default.
- W2088165738 hasRelatedWork W2102630937 @default.
- W2088165738 hasRelatedWork W2105208588 @default.
- W2088165738 hasRelatedWork W2147856180 @default.
- W2088165738 hasRelatedWork W2314598075 @default.
- W2088165738 hasRelatedWork W2332189489 @default.
- W2088165738 hasRelatedWork W2398855022 @default.
- W2088165738 hasRelatedWork W2407774834 @default.
- W2088165738 hasRelatedWork W2409666033 @default.
- W2088165738 hasRelatedWork W253625367 @default.
- W2088165738 hasRelatedWork W2769345299 @default.
- W2088165738 hasRelatedWork W78203264 @default.
- W2088165738 isParatext "false" @default.
- W2088165738 isRetracted "false" @default.
- W2088165738 magId "2088165738" @default.
- W2088165738 workType "article" @default.