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• W2088177531 abstract "ABSTRACT Proliferation responses of naïve CD4 + T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV + ) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healthy controls and from HIV + subjects. The overall response to T-cell receptor stimulation alone or in combination with IL-7, however, was diminished among viremic HIV + donors and occurred independent of antigen-presenting cells. Frequencies of CD127 + cells were related to the magnitudes of proliferation enhancement that were mediated by IL-7. Thus, IL-7 enhances but does not fully restore the function of naïve CD4 + T cells from HIV-infected persons." @default.
• W2088177531 created "2016-06-24" @default.
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• W2088177531 date "2007-11-15" @default.
• W2088177531 modified "2023-09-24" @default.
• W2088177531 title "Interleukin-7 Enhances Proliferation Responses to T-Cell Receptor Stimulation in Naïve CD4 + T Cells from Human Immunodeficiency Virus-Infected Persons" @default.
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• W2088177531 doi "https://doi.org/10.1128/jvi.00476-07" @default.
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