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- W2088180456 abstract "The effects of the voltage-dependent Ca2+ inward current (ICa) on gamma-aminobutyric acid (GABA)-induced Cl- current (ICl) in isolated frog sensory neurons were examined at different temperatures and with different concentrations of external Ca2+ using the 'concentration-clamp' technique. The total amount of inhibition of GABA-induced ICl by a preceding ICa increased in a hyperbolic manner with increasing Ca2+ influx. The time course of recovery of the GABA response after inhibition by Ca2+ influx followed a single exponential and was facilitated by warming but slowed dramatically by a slight cooling from 20 to 15 degrees C in spite of a decrease in Ca2+ influx. It is discussed that the energy-dependent, temperature-sensitive ionic pump and exchange systems at the surface membrane and intracellular organelles regulate the cytoplasmic free Ca2+, thus explaining the quantitative effects of Ca2+ influx and temperature on the inhibition of the GABA-gated Cl- channel." @default.
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- W2088180456 date "1990-01-01" @default.
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- W2088180456 title "Effect of temperature on the inhibition of the GABA-gated response by intracellular calcium" @default.
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- W2088180456 doi "https://doi.org/10.1016/0006-8993(90)90515-d" @default.
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