FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088184514> ?p ?o ?g. }

• W2088184514 endingPage "920" @default.
• W2088184514 startingPage "914" @default.
• W2088184514 abstract "Background. This study assesses the safety and efficacy of the novel human anti-human CD154 monoclonal antibody ABI793 in rhesus monkeys. Methods. Outbred rhesus monkeys were used for renal transplantation from major histocompatibility complex-mismatched donors. Seven recipients were treated with ABI793, and six untreated recipients were used as controls. Graft function was monitored by urine output, serum creatinine, and renal biopsy. Phenotypic analysis of peripheral blood lymphocytes and mixed lymphocyte reaction were performed before transplantation and periodically after transplantation. Anti-donor major histocompatibility complex class I antibody levels were measured at the time of sacrifice. Results. Monkeys in the treated group demonstrated prolonged graft survival compared with controls. One monkey was sacrificed because of a urine leak on postoperative day 13. Three monkeys were sacrificed because of acute rejection (days 44, 149, and 158). Two monkeys were sacrificed because of chronic active rejection (days 154 and 221). One monkey was sacrificed on day 139 without rejection to observe the effects of ABI793 in the absence of rejection. There were no obvious clinical side effects of ABI793, but microscopic thromboembolic changes were observed in two monkeys. Lymphocyte subsets remained unaltered in all monkeys. Mixed lymphocyte reaction showed nonspecific suppression 6 weeks after transplantation. The monkeys with chronic active rejection showed relatively strong alloantibody responses. Conclusions. ABI793 induces prolonged renal allograft survival in rhesus monkeys. Nevertheless, thromboembolic complications may occur and chronic allograft nephropathy may develop after anti-CD154 treatment is discontinued." @default.
• W2088184514 created "2016-06-24" @default.
• W2088184514 creator A5001005514 @default.
• W2088184514 creator A5005316147 @default.
• W2088184514 creator A5007869873 @default.
• W2088184514 creator A5011128403 @default.
• W2088184514 creator A5016394693 @default.
• W2088184514 creator A5017903974 @default.
• W2088184514 creator A5031082112 @default.
• W2088184514 creator A5033263223 @default.
• W2088184514 creator A5038026362 @default.
• W2088184514 creator A5041151171 @default.
• W2088184514 creator A5044082468 @default.
• W2088184514 creator A5055325162 @default.
• W2088184514 creator A5059362407 @default.
• W2088184514 creator A5063525307 @default.
• W2088184514 creator A5084079717 @default.
• W2088184514 date "2004-03-27" @default.
• W2088184514 modified "2023-10-16" @default.
• W2088184514 title "Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model1" @default.
• W2088184514 cites W1485526722 @default.
• W2088184514 cites W1497143986 @default.
• W2088184514 cites W1561516029 @default.
• W2088184514 cites W1581554632 @default.
• W2088184514 cites W1964997094 @default.
• W2088184514 cites W1995592697 @default.
• W2088184514 cites W1995791071 @default.
• W2088184514 cites W1996856059 @default.
• W2088184514 cites W2008367578 @default.
• W2088184514 cites W2023492750 @default.
• W2088184514 cites W2025123869 @default.
• W2088184514 cites W2041674741 @default.
• W2088184514 cites W2052568328 @default.
• W2088184514 cites W2054083392 @default.
• W2088184514 cites W2054540030 @default.
• W2088184514 cites W2081673391 @default.
• W2088184514 cites W2084407937 @default.
• W2088184514 cites W2098123605 @default.
• W2088184514 cites W2118061894 @default.
• W2088184514 cites W2412349014 @default.
• W2088184514 cites W4242417152 @default.
• W2088184514 cites W4249146601 @default.
• W2088184514 doi "https://doi.org/10.1097/01.tp.0000116392.72152.75" @default.
• W2088184514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15077037" @default.
• W2088184514 hasPublicationYear "2004" @default.
• W2088184514 type Work @default.
• W2088184514 sameAs 2088184514 @default.
• W2088184514 citedByCount "74" @default.
• W2088184514 countsByYear W20881845142012 @default.
• W2088184514 countsByYear W20881845142013 @default.
• W2088184514 countsByYear W20881845142014 @default.
• W2088184514 countsByYear W20881845142015 @default.
• W2088184514 countsByYear W20881845142016 @default.
• W2088184514 countsByYear W20881845142017 @default.
• W2088184514 countsByYear W20881845142018 @default.
• W2088184514 countsByYear W20881845142019 @default.
• W2088184514 countsByYear W20881845142020 @default.
• W2088184514 countsByYear W20881845142021 @default.
• W2088184514 countsByYear W20881845142022 @default.
• W2088184514 countsByYear W20881845142023 @default.
• W2088184514 crossrefType "journal-article" @default.
• W2088184514 hasAuthorship W2088184514A5001005514 @default.
• W2088184514 hasAuthorship W2088184514A5005316147 @default.
• W2088184514 hasAuthorship W2088184514A5007869873 @default.
• W2088184514 hasAuthorship W2088184514A5011128403 @default.
• W2088184514 hasAuthorship W2088184514A5016394693 @default.
• W2088184514 hasAuthorship W2088184514A5017903974 @default.
• W2088184514 hasAuthorship W2088184514A5031082112 @default.
• W2088184514 hasAuthorship W2088184514A5033263223 @default.
• W2088184514 hasAuthorship W2088184514A5038026362 @default.
• W2088184514 hasAuthorship W2088184514A5041151171 @default.
• W2088184514 hasAuthorship W2088184514A5044082468 @default.
• W2088184514 hasAuthorship W2088184514A5055325162 @default.
• W2088184514 hasAuthorship W2088184514A5059362407 @default.
• W2088184514 hasAuthorship W2088184514A5063525307 @default.
• W2088184514 hasAuthorship W2088184514A5084079717 @default.
• W2088184514 hasBestOaLocation W20881845141 @default.
• W2088184514 hasConcept C126322002 @default.
• W2088184514 hasConcept C126894567 @default.
• W2088184514 hasConcept C142724271 @default.
• W2088184514 hasConcept C159654299 @default.
• W2088184514 hasConcept C203014093 @default.
• W2088184514 hasConcept C2776090121 @default.
• W2088184514 hasConcept C2777761686 @default.
• W2088184514 hasConcept C2778740727 @default.
• W2088184514 hasConcept C2780303639 @default.
• W2088184514 hasConcept C2780306776 @default.
• W2088184514 hasConcept C2780829873 @default.
• W2088184514 hasConcept C2911091166 @default.
• W2088184514 hasConcept C542903549 @default.
• W2088184514 hasConcept C71924100 @default.
• W2088184514 hasConcept C8891405 @default.
• W2088184514 hasConceptScore W2088184514C126322002 @default.
• W2088184514 hasConceptScore W2088184514C126894567 @default.
• W2088184514 hasConceptScore W2088184514C142724271 @default.
• W2088184514 hasConceptScore W2088184514C159654299 @default.
• W2088184514 hasConceptScore W2088184514C203014093 @default.
• W2088184514 hasConceptScore W2088184514C2776090121 @default.

• next