Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088188445> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2088188445 endingPage "103" @default.
- W2088188445 startingPage "92" @default.
- W2088188445 abstract "Abstract Intact and pure nuclei were isolated by zonal centrifugation from calf uteri preincubated with [ 3 H] estradiol at 37°C. Alternatively, labelling of nuclei was performed by cell-free incubation of filtrate homogenates with radio-active homone at 25°C. The kinetics of dissociation of the estradiol—receptor complex was studied by the tritiated estradiol—non-radioactiv estradiol-exchange method at 22°C using: (a) intact nuclei and isolated chromatin, (b) a 0.5M KCl nuclear extract (5 S) and different cytosolic preparations (4 S, 8 S or heavy aggregates), or (c) cytosolic extracts bound to an inert support like hydroxylapatite or precipitated by nuclear basic proteins. In the three groups the dissociation follows the well established two-stage first-order kinetics patterns, but whereas in Group a the operational half-life of the complex was 5 h, all the preparations of Group b, including the nuclear extract, yielded a half-life of only 10 min. Intermediate values were obtained for the preparations of Group c. Its concluded that the binding to the chromatin endows the estradiol— receptor complex with a higher stability. This might account for the characteristic retention of estradiol in uterine cells in in vivo conditions." @default.
- W2088188445 created "2016-06-24" @default.
- W2088188445 creator A5066740582 @default.
- W2088188445 creator A5076376618 @default.
- W2088188445 date "1974-01-25" @default.
- W2088188445 modified "2023-09-26" @default.
- W2088188445 title "Dissociation studies of different forms of the estradiol-receptor complex from calf uterus: Higher stability of the complex bound to chromatin" @default.
- W2088188445 cites W1491804745 @default.
- W2088188445 cites W1506043065 @default.
- W2088188445 cites W1575089413 @default.
- W2088188445 cites W1603357054 @default.
- W2088188445 cites W1969197892 @default.
- W2088188445 cites W1971403740 @default.
- W2088188445 cites W1977839166 @default.
- W2088188445 cites W1997402760 @default.
- W2088188445 cites W2048696126 @default.
- W2088188445 cites W2083305120 @default.
- W2088188445 cites W2111648388 @default.
- W2088188445 cites W2139026276 @default.
- W2088188445 cites W2261816148 @default.
- W2088188445 cites W2282054059 @default.
- W2088188445 doi "https://doi.org/10.1016/0304-4165(74)90339-0" @default.
- W2088188445 hasPublicationYear "1974" @default.
- W2088188445 type Work @default.
- W2088188445 sameAs 2088188445 @default.
- W2088188445 citedByCount "19" @default.
- W2088188445 crossrefType "journal-article" @default.
- W2088188445 hasAuthorship W2088188445A5066740582 @default.
- W2088188445 hasAuthorship W2088188445A5076376618 @default.
- W2088188445 hasConcept C102931765 @default.
- W2088188445 hasConcept C126322002 @default.
- W2088188445 hasConcept C134018914 @default.
- W2088188445 hasConcept C147789679 @default.
- W2088188445 hasConcept C170493617 @default.
- W2088188445 hasConcept C185592680 @default.
- W2088188445 hasConcept C2779066055 @default.
- W2088188445 hasConcept C552990157 @default.
- W2088188445 hasConcept C55493867 @default.
- W2088188445 hasConcept C71924100 @default.
- W2088188445 hasConcept C83640560 @default.
- W2088188445 hasConcept C86803240 @default.
- W2088188445 hasConcept C95444343 @default.
- W2088188445 hasConceptScore W2088188445C102931765 @default.
- W2088188445 hasConceptScore W2088188445C126322002 @default.
- W2088188445 hasConceptScore W2088188445C134018914 @default.
- W2088188445 hasConceptScore W2088188445C147789679 @default.
- W2088188445 hasConceptScore W2088188445C170493617 @default.
- W2088188445 hasConceptScore W2088188445C185592680 @default.
- W2088188445 hasConceptScore W2088188445C2779066055 @default.
- W2088188445 hasConceptScore W2088188445C552990157 @default.
- W2088188445 hasConceptScore W2088188445C55493867 @default.
- W2088188445 hasConceptScore W2088188445C71924100 @default.
- W2088188445 hasConceptScore W2088188445C83640560 @default.
- W2088188445 hasConceptScore W2088188445C86803240 @default.
- W2088188445 hasConceptScore W2088188445C95444343 @default.
- W2088188445 hasIssue "1" @default.
- W2088188445 hasLocation W20881884451 @default.
- W2088188445 hasOpenAccess W2088188445 @default.
- W2088188445 hasPrimaryLocation W20881884451 @default.
- W2088188445 hasRelatedWork W1963919935 @default.
- W2088188445 hasRelatedWork W1979660518 @default.
- W2088188445 hasRelatedWork W2018368842 @default.
- W2088188445 hasRelatedWork W2033472167 @default.
- W2088188445 hasRelatedWork W2034583712 @default.
- W2088188445 hasRelatedWork W2063619316 @default.
- W2088188445 hasRelatedWork W2074821979 @default.
- W2088188445 hasRelatedWork W2107761980 @default.
- W2088188445 hasRelatedWork W2169225653 @default.
- W2088188445 hasRelatedWork W2414846389 @default.
- W2088188445 hasVolume "338" @default.
- W2088188445 isParatext "false" @default.
- W2088188445 isRetracted "false" @default.
- W2088188445 magId "2088188445" @default.
- W2088188445 workType "article" @default.