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• W2088189887 abstract "Seven volunteers inhaled monodisperse 1.2 and 3.9 μm dia. (1.9 and 6.1 μm equivalent aerodynamic diameter) fused aluminosilicate particles labelled with 85 Sr and 88 Y respectively. Lung retention has been followed for over 200 days. Approximately 8% of 1.2 μm and 40% of 3.9 μm particles cleared within 6 days. It was calculated that these fractions were deposited within the conducting airways and therefore no rapid alveolar clearance was observed. Overall retention of the remaining material showed half-times averaging 320 days, with considerable intersubject variation but little effect of particle size. Two-component exponential functions represented retention more satisfactorily. Approximately 4% of 1.2 μm and 11% of 3.9 μm particles retained at 6 days cleared with a half-time of about 20 days, the rest with half-times of 330 and 420 days respectively. Estimated lung dissolution rates were 1×10 −3 and 5×10 −4 d −1 for 1.2 and 3.9 μm particles, indicating that for both sizes mechanical clearance shows a slow phase with a half-time of about 600 days." @default.
• W2088189887 created "2016-06-24" @default.
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• W2088189887 date "1982-02-01" @default.
• W2088189887 modified "2023-09-25" @default.
• W2088189887 title "THE LONG-TERM CLEARANCE KINETICS OF INSOLUBLE PARTICLES FROM THE HUMAN LUNG" @default.
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• W2088189887 doi "https://doi.org/10.1093/annhyg/26.2.273" @default.
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