FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088195456> ?p ?o ?g. }

• W2088195456 endingPage "439" @default.
• W2088195456 startingPage "432" @default.
• W2088195456 abstract "Thromboxane A2, produced from the arachidonic acid released from platelet phospholipids by phospholipase A2, stimulates platelet aggregation. It remains unresolved whether additional products of platelet phospholipase A2 might promote aggregation. To address this question, we have used aspirin-treated platelets to block thromboxane A2 formation and studied the influence of the phospholipase A2 inhibitor U10029A on platelet aggregation and secretion in response to thrombin. U10029A at 100 microM markedly inhibited platelet aggregation, but had no effect on platelet secretion. Since this concentration of U10029A effectively blocked lysophosphatidic acid (LPA) formation, LPA was added and found to substantially reverse the inhibitory effect of U10029A in these platelets. Furthermore, the action of U10029A was not due to inhibition of phosphatidate phosphohydrolase because U10029A, unlike propranolol, did not inhibit this enzyme. Although it is not possible to conclusively rule out an effect of U10029A in addition to its inhibition of phospholipase A2, our results reveal that a product of phospholipase A2 other than thromboxane A2 is important for platelet aggregation, but not for secretion in response to thrombin. Our data suggest that this product is LPA. Since the amount of phosphatidic acid (PA) increased dramatically concurrent with inhibition of platelet aggregation, it is safe to conclude that PA has no direct role to promote platelet aggregation in response to thrombin." @default.
• W2088195456 created "2016-06-24" @default.
• W2088195456 creator A5008687660 @default.
• W2088195456 creator A5018837258 @default.
• W2088195456 creator A5026209355 @default.
• W2088195456 creator A5059879827 @default.
• W2088195456 date "1993-09-01" @default.
• W2088195456 modified "2023-10-18" @default.
• W2088195456 title "Increased phosphatidic acid and decreased lysophosphatidic acid in response to thrombin is associated with inhibition of platelet aggregation" @default.
• W2088195456 cites W126310588 @default.
• W2088195456 cites W1493283928 @default.
• W2088195456 cites W1512600725 @default.
• W2088195456 cites W1598223054 @default.
• W2088195456 cites W1903779798 @default.
• W2088195456 cites W1972470633 @default.
• W2088195456 cites W1978484948 @default.
• W2088195456 cites W1986919612 @default.
• W2088195456 cites W1996922835 @default.
• W2088195456 cites W2003197672 @default.
• W2088195456 cites W2003271809 @default.
• W2088195456 cites W2020766558 @default.
• W2088195456 cites W2033548549 @default.
• W2088195456 cites W2038049723 @default.
• W2088195456 cites W2061375880 @default.
• W2088195456 cites W2070206012 @default.
• W2088195456 cites W2087632630 @default.
• W2088195456 cites W2124647612 @default.
• W2088195456 cites W2148800894 @default.
• W2088195456 cites W2149439788 @default.
• W2088195456 cites W2212849247 @default.
• W2088195456 cites W2225582428 @default.
• W2088195456 cites W2338738191 @default.
• W2088195456 cites W2404461233 @default.
• W2088195456 cites W2409604495 @default.
• W2088195456 cites W2413562772 @default.
• W2088195456 cites W2464058341 @default.
• W2088195456 cites W334592368 @default.
• W2088195456 doi "https://doi.org/10.1139/o93-064" @default.
• W2088195456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8192895" @default.
• W2088195456 hasPublicationYear "1993" @default.
• W2088195456 type Work @default.
• W2088195456 sameAs 2088195456 @default.
• W2088195456 citedByCount "21" @default.
• W2088195456 countsByYear W20881954562013 @default.
• W2088195456 countsByYear W20881954562015 @default.
• W2088195456 crossrefType "journal-article" @default.
• W2088195456 hasAuthorship W2088195456A5008687660 @default.
• W2088195456 hasAuthorship W2088195456A5018837258 @default.
• W2088195456 hasAuthorship W2088195456A5026209355 @default.
• W2088195456 hasAuthorship W2088195456A5059879827 @default.
• W2088195456 hasConcept C126322002 @default.
• W2088195456 hasConcept C12927208 @default.
• W2088195456 hasConcept C170493617 @default.
• W2088195456 hasConcept C181199279 @default.
• W2088195456 hasConcept C185592680 @default.
• W2088195456 hasConcept C2776551241 @default.
• W2088195456 hasConcept C2776661833 @default.
• W2088195456 hasConcept C2776785769 @default.
• W2088195456 hasConcept C2776909261 @default.
• W2088195456 hasConcept C2777292125 @default.
• W2088195456 hasConcept C2778078955 @default.
• W2088195456 hasConcept C2778918659 @default.
• W2088195456 hasConcept C2781024287 @default.
• W2088195456 hasConcept C41625074 @default.
• W2088195456 hasConcept C55493867 @default.
• W2088195456 hasConcept C6182249 @default.
• W2088195456 hasConcept C71924100 @default.
• W2088195456 hasConcept C86803240 @default.
• W2088195456 hasConcept C89560881 @default.
• W2088195456 hasConcept C98274493 @default.
• W2088195456 hasConceptScore W2088195456C126322002 @default.
• W2088195456 hasConceptScore W2088195456C12927208 @default.
• W2088195456 hasConceptScore W2088195456C170493617 @default.
• W2088195456 hasConceptScore W2088195456C181199279 @default.
• W2088195456 hasConceptScore W2088195456C185592680 @default.
• W2088195456 hasConceptScore W2088195456C2776551241 @default.
• W2088195456 hasConceptScore W2088195456C2776661833 @default.
• W2088195456 hasConceptScore W2088195456C2776785769 @default.
• W2088195456 hasConceptScore W2088195456C2776909261 @default.
• W2088195456 hasConceptScore W2088195456C2777292125 @default.
• W2088195456 hasConceptScore W2088195456C2778078955 @default.
• W2088195456 hasConceptScore W2088195456C2778918659 @default.
• W2088195456 hasConceptScore W2088195456C2781024287 @default.
• W2088195456 hasConceptScore W2088195456C41625074 @default.
• W2088195456 hasConceptScore W2088195456C55493867 @default.
• W2088195456 hasConceptScore W2088195456C6182249 @default.
• W2088195456 hasConceptScore W2088195456C71924100 @default.
• W2088195456 hasConceptScore W2088195456C86803240 @default.
• W2088195456 hasConceptScore W2088195456C89560881 @default.
• W2088195456 hasConceptScore W2088195456C98274493 @default.
• W2088195456 hasIssue "9-10" @default.
• W2088195456 hasLocation W20881954561 @default.
• W2088195456 hasLocation W20881954562 @default.
• W2088195456 hasOpenAccess W2088195456 @default.
• W2088195456 hasPrimaryLocation W20881954561 @default.
• W2088195456 hasRelatedWork W153398886 @default.
• W2088195456 hasRelatedWork W1691884031 @default.
• W2088195456 hasRelatedWork W1986919612 @default.

• next