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- W2088202340 abstract "Induction of cytochrome P1-450 has been linked to susceptibility to certain chemically induced cancers in mouse and man. Treatment of the human cell line MCF-7 with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) results in high levels of aryl hydrocarbon (benzo[a]pyrene) hydroxylase (P1-450) activity. This cell line was used to isolate a human P1-450 full-length complementary DNA (cDNA) clone. The cDNA is 2566 nucleotides in length, encodes a polyadenylated messenger RNA (2.8 kilobases in length), and has a continuous reading frame producing a protein with 512 residues (molecular weight, 58,151). The human P1-450 cDNA and protein are 63 percent and 80 percent similar to mouse P1-450 cDNA and protein, respectively. Whereas the mouse TCDD-inducible P-450 gene subfamily has two members (P1-450 and P3-450), the human TCDD-inducible gene subfamily appears to have only one gene (P1-450)." @default.
- W2088202340 created "2016-06-24" @default.
- W2088202340 creator A5027903995 @default.
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- W2088202340 date "1985-04-05" @default.
- W2088202340 modified "2023-10-16" @default.
- W2088202340 title "Human Dioxin-Inducible Cytochrome P <sub>1</sub> -450: Complementary DNA and Amino Acid Sequence" @default.
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- W2088202340 doi "https://doi.org/10.1126/science.3838385" @default.
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