Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088218326> ?p ?o ?g. }
- W2088218326 endingPage "1940" @default.
- W2088218326 startingPage "1940" @default.
- W2088218326 abstract "Parkinson's disease (PD) is a common neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. To further explore potential functional mechanisms of PD, we performed a comparative proteomic analysis using stable isotope labeling with amino acids in cell culture (SILAC) combined with nano-LC tandem mass spectrometry (nano-LC MS). In total, 1740 proteins were identified in MPP+-treated SH-SY5Y cells. Our comparative proteomic analysis indicated that a total of 39 proteins were differentially expressed in SH-SY5Y cells responding to MPP+ treatment. Of these, 14 altered proteins were clustered in the mitochondria, 5 proteins were already reported as related to PD, and the remaining proteins were newly identified in this study. Together, our data further define that the mitochondria play an important role in regulating PD through multiple and complex mechanisms and provide new insights into the functional contribution of mitochondrial proteins in PD." @default.
- W2088218326 created "2016-06-24" @default.
- W2088218326 creator A5009658070 @default.
- W2088218326 creator A5042960453 @default.
- W2088218326 creator A5066556622 @default.
- W2088218326 date "2014-01-01" @default.
- W2088218326 modified "2023-10-12" @default.
- W2088218326 title "Quantitative proteomic analysis reveals mitochondrial protein changes in MPP+-induced neuronal cells" @default.
- W2088218326 cites W1797925867 @default.
- W2088218326 cites W1963577160 @default.
- W2088218326 cites W1967178211 @default.
- W2088218326 cites W1969026701 @default.
- W2088218326 cites W1970095022 @default.
- W2088218326 cites W1998287296 @default.
- W2088218326 cites W1999971438 @default.
- W2088218326 cites W2002482269 @default.
- W2088218326 cites W2002764641 @default.
- W2088218326 cites W2006696253 @default.
- W2088218326 cites W2015556811 @default.
- W2088218326 cites W2024071559 @default.
- W2088218326 cites W2027708488 @default.
- W2088218326 cites W2030411545 @default.
- W2088218326 cites W2058075792 @default.
- W2088218326 cites W2063256813 @default.
- W2088218326 cites W2066289113 @default.
- W2088218326 cites W2075589522 @default.
- W2088218326 cites W2092108876 @default.
- W2088218326 cites W2104382960 @default.
- W2088218326 cites W2106296386 @default.
- W2088218326 cites W2112078820 @default.
- W2088218326 cites W2119873134 @default.
- W2088218326 cites W2134862369 @default.
- W2088218326 cites W2137748756 @default.
- W2088218326 cites W2624338235 @default.
- W2088218326 doi "https://doi.org/10.1039/c4mb00026a" @default.
- W2088218326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24806433" @default.
- W2088218326 hasPublicationYear "2014" @default.
- W2088218326 type Work @default.
- W2088218326 sameAs 2088218326 @default.
- W2088218326 citedByCount "11" @default.
- W2088218326 countsByYear W20882183262015 @default.
- W2088218326 countsByYear W20882183262016 @default.
- W2088218326 countsByYear W20882183262017 @default.
- W2088218326 countsByYear W20882183262018 @default.
- W2088218326 countsByYear W20882183262019 @default.
- W2088218326 countsByYear W20882183262020 @default.
- W2088218326 countsByYear W20882183262021 @default.
- W2088218326 countsByYear W20882183262022 @default.
- W2088218326 countsByYear W20882183262023 @default.
- W2088218326 crossrefType "journal-article" @default.
- W2088218326 hasAuthorship W2088218326A5009658070 @default.
- W2088218326 hasAuthorship W2088218326A5042960453 @default.
- W2088218326 hasAuthorship W2088218326A5066556622 @default.
- W2088218326 hasConcept C104317684 @default.
- W2088218326 hasConcept C137183658 @default.
- W2088218326 hasConcept C142724271 @default.
- W2088218326 hasConcept C162356407 @default.
- W2088218326 hasConcept C169760540 @default.
- W2088218326 hasConcept C185592680 @default.
- W2088218326 hasConcept C2776773494 @default.
- W2088218326 hasConcept C2776925932 @default.
- W2088218326 hasConcept C2779134260 @default.
- W2088218326 hasConcept C2779734285 @default.
- W2088218326 hasConcept C2780938664 @default.
- W2088218326 hasConcept C28859421 @default.
- W2088218326 hasConcept C31827203 @default.
- W2088218326 hasConcept C34905852 @default.
- W2088218326 hasConcept C43617362 @default.
- W2088218326 hasConcept C46111723 @default.
- W2088218326 hasConcept C513476851 @default.
- W2088218326 hasConcept C55493867 @default.
- W2088218326 hasConcept C71924100 @default.
- W2088218326 hasConcept C80311884 @default.
- W2088218326 hasConcept C86153913 @default.
- W2088218326 hasConcept C86803240 @default.
- W2088218326 hasConcept C95444343 @default.
- W2088218326 hasConceptScore W2088218326C104317684 @default.
- W2088218326 hasConceptScore W2088218326C137183658 @default.
- W2088218326 hasConceptScore W2088218326C142724271 @default.
- W2088218326 hasConceptScore W2088218326C162356407 @default.
- W2088218326 hasConceptScore W2088218326C169760540 @default.
- W2088218326 hasConceptScore W2088218326C185592680 @default.
- W2088218326 hasConceptScore W2088218326C2776773494 @default.
- W2088218326 hasConceptScore W2088218326C2776925932 @default.
- W2088218326 hasConceptScore W2088218326C2779134260 @default.
- W2088218326 hasConceptScore W2088218326C2779734285 @default.
- W2088218326 hasConceptScore W2088218326C2780938664 @default.
- W2088218326 hasConceptScore W2088218326C28859421 @default.
- W2088218326 hasConceptScore W2088218326C31827203 @default.
- W2088218326 hasConceptScore W2088218326C34905852 @default.
- W2088218326 hasConceptScore W2088218326C43617362 @default.
- W2088218326 hasConceptScore W2088218326C46111723 @default.
- W2088218326 hasConceptScore W2088218326C513476851 @default.
- W2088218326 hasConceptScore W2088218326C55493867 @default.
- W2088218326 hasConceptScore W2088218326C71924100 @default.
- W2088218326 hasConceptScore W2088218326C80311884 @default.
- W2088218326 hasConceptScore W2088218326C86153913 @default.
- W2088218326 hasConceptScore W2088218326C86803240 @default.