FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088250393> ?p ?o ?g. }

• W2088250393 endingPage "665" @default.
• W2088250393 startingPage "659" @default.
• W2088250393 abstract "Objective The immunosuppressive drug tacrolimus requires strict therapeutic monitoring due to its narrow therapeutic index and great inter-individual variability. Cytochrome P450 3A4 (Cyp3A4) and Cyp3A5 are the most important contributors to tacrolimus metabolism while the P-glycoprotein pump (MDR-1) modulates its bioavailability. The objective was to investigate the association between Cyp3A4, Cyp3A5, and MDR-1 polymorphisms and tacrolimus pharmacokinetics in the early period after renal transplantation. Methods Forty-four renal transplant recipients were genotyped for 8 Cyp3A4, 7 Cyp3A5, and 5 MDR-1 genetic variants affecting the proteins' expression and/or function. Dose-adjusted tacrolimus though levels were determined during the first week after transplantation and correlated with corresponding genotype. Results We found no correlation between Cyp3A4 polymorphism and tacrolimus pharmacokinetics. Patients who do not carry both Cyp3A5*3 alleles achieved lower mean dose-adjusted tacrolimus blood concentrations (p<0.001) and needed a longer time to reach the target concentration (10–12 ng/ml; p<0.001) compared to Cyp3A5*3 homozygotes. Patients with less than three copies of MDR-1 (T-129C, C3435T and G2677T) polymorphisms, associated with reduced expression of P-glycoprotein, had also lower dose-adjusted tacrolimus blood concentrations compared to patients having equal to or greater than three copies of MDR-1 genetic variants (P=0.003). There was no difference in the rate of biopsy-confirmed acute rejection among groups during the first 3 months after transplantation. Conclusion The complete absence of Cyp3A5*3 allele and the accumulation of less than three copies of MDR-1 (T-129C, C3435T and G2677T) polymorphisms are associated with lower tacrolimus blood levels identifying these genotypes as markers for patients requiring higher tacrolimus doses." @default.
• W2088250393 created "2016-06-24" @default.
• W2088250393 creator A5005435540 @default.
• W2088250393 creator A5005618879 @default.
• W2088250393 creator A5056281976 @default.
• W2088250393 creator A5065275231 @default.
• W2088250393 creator A5083068598 @default.
• W2088250393 date "2006-09-01" @default.
• W2088250393 modified "2023-10-02" @default.
• W2088250393 title "Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients" @default.
• W2088250393 cites W1912531397 @default.
• W2088250393 cites W1964698840 @default.
• W2088250393 cites W1966423093 @default.
• W2088250393 cites W1971182486 @default.
• W2088250393 cites W1975261946 @default.
• W2088250393 cites W1995791071 @default.
• W2088250393 cites W1999502217 @default.
• W2088250393 cites W2004411083 @default.
• W2088250393 cites W2007364301 @default.
• W2088250393 cites W2021775978 @default.
• W2088250393 cites W2024131514 @default.
• W2088250393 cites W2034728660 @default.
• W2088250393 cites W2043431574 @default.
• W2088250393 cites W2048793396 @default.
• W2088250393 cites W2054458932 @default.
• W2088250393 cites W2056897801 @default.
• W2088250393 cites W2060016825 @default.
• W2088250393 cites W2066919313 @default.
• W2088250393 cites W2072623157 @default.
• W2088250393 cites W2077109037 @default.
• W2088250393 cites W2077324231 @default.
• W2088250393 cites W2079308844 @default.
• W2088250393 cites W2083650072 @default.
• W2088250393 cites W2085067466 @default.
• W2088250393 cites W2090876589 @default.
• W2088250393 cites W2096675998 @default.
• W2088250393 cites W2105902511 @default.
• W2088250393 cites W2126262050 @default.
• W2088250393 cites W2152193974 @default.
• W2088250393 cites W2161386118 @default.
• W2088250393 cites W2358501499 @default.
• W2088250393 cites W2414200306 @default.
• W2088250393 cites W2791969457 @default.
• W2088250393 doi "https://doi.org/10.1097/01.fpc.0000220571.20961.dd" @default.
• W2088250393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16906020" @default.
• W2088250393 hasPublicationYear "2006" @default.
• W2088250393 type Work @default.
• W2088250393 sameAs 2088250393 @default.
• W2088250393 citedByCount "102" @default.
• W2088250393 countsByYear W20882503932012 @default.
• W2088250393 countsByYear W20882503932013 @default.
• W2088250393 countsByYear W20882503932014 @default.
• W2088250393 countsByYear W20882503932015 @default.
• W2088250393 countsByYear W20882503932016 @default.
• W2088250393 countsByYear W20882503932017 @default.
• W2088250393 countsByYear W20882503932018 @default.
• W2088250393 countsByYear W20882503932019 @default.
• W2088250393 countsByYear W20882503932020 @default.
• W2088250393 countsByYear W20882503932021 @default.
• W2088250393 countsByYear W20882503932022 @default.
• W2088250393 countsByYear W20882503932023 @default.
• W2088250393 crossrefType "journal-article" @default.
• W2088250393 hasAuthorship W2088250393A5005435540 @default.
• W2088250393 hasAuthorship W2088250393A5005618879 @default.
• W2088250393 hasAuthorship W2088250393A5056281976 @default.
• W2088250393 hasAuthorship W2088250393A5065275231 @default.
• W2088250393 hasAuthorship W2088250393A5083068598 @default.
• W2088250393 hasConcept C104317684 @default.
• W2088250393 hasConcept C109650736 @default.
• W2088250393 hasConcept C112705442 @default.
• W2088250393 hasConcept C126322002 @default.
• W2088250393 hasConcept C128057223 @default.
• W2088250393 hasConcept C135763542 @default.
• W2088250393 hasConcept C2780303639 @default.
• W2088250393 hasConcept C2909675724 @default.
• W2088250393 hasConcept C2911091166 @default.
• W2088250393 hasConcept C526171541 @default.
• W2088250393 hasConcept C54355233 @default.
• W2088250393 hasConcept C55775858 @default.
• W2088250393 hasConcept C62231903 @default.
• W2088250393 hasConcept C71924100 @default.
• W2088250393 hasConcept C86803240 @default.
• W2088250393 hasConcept C90924648 @default.
• W2088250393 hasConcept C92137452 @default.
• W2088250393 hasConcept C98274493 @default.
• W2088250393 hasConceptScore W2088250393C104317684 @default.
• W2088250393 hasConceptScore W2088250393C109650736 @default.
• W2088250393 hasConceptScore W2088250393C112705442 @default.
• W2088250393 hasConceptScore W2088250393C126322002 @default.
• W2088250393 hasConceptScore W2088250393C128057223 @default.
• W2088250393 hasConceptScore W2088250393C135763542 @default.
• W2088250393 hasConceptScore W2088250393C2780303639 @default.
• W2088250393 hasConceptScore W2088250393C2909675724 @default.
• W2088250393 hasConceptScore W2088250393C2911091166 @default.
• W2088250393 hasConceptScore W2088250393C526171541 @default.
• W2088250393 hasConceptScore W2088250393C54355233 @default.
• W2088250393 hasConceptScore W2088250393C55775858 @default.
• W2088250393 hasConceptScore W2088250393C62231903 @default.

• next