FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088252859> ?p ?o ?g. }

• W2088252859 endingPage "467" @default.
• W2088252859 startingPage "457" @default.
• W2088252859 abstract "Inactivation of the von Hippel-Lindau (VHL) tumor-suppressor gene causes both the familial cancer syndrome VHL disease and corresponding sporadic tumor types, including renal-cell carcinoma. Subcellular localization of VHL gene products was determined by indirect immunofluorescence. Both native and exogenously expressed VHL proteins displayed a cytoplasmic peri-nuclear immunostaining pattern, which co-localized with markers for the endoplasmic reticulum (ER). In addition, subcellular fractionation indicated that both native and exogenously expressed VHL products are found predominantly in the cytosolic compartment. Deletion analyses demonstrated that a 64-amino acid region of VHL (residues 114-177) is responsible for cytosolic as well as ER subcellular localization. Taken together, the immunostaining and biochemical fractionation studies suggest that VHL localizes to the cytosolic face of the ER. The relationship between VHL subcellular localization and VHL-associated ubiquitination was examined. Chimeric VHL-green fluorescent protein (GFP) products, which localized to the peri-nuclear region, were shown to undergo ubiquitination. VHL amino acids 114-177 were necessary and sufficient for this modification. Consistent with a role of VHL in ubiquitination, expression of VHL led to enhanced ubiquitination of cellular proteins, and amino acids 114-177 were also critical for this effect. Therefore, amino acids 114-177 were required for accurate VHL subcellular localization, ubiquitination of VHL-GFP products and VHL-dependent increases in cellular ubiquitination. Since mutations in this region of VHL are frequently detected in renal-cell carcinomas, these results suggest that proper VHL subcellular localization and associated ubiquitination functions may be necessary for VHL-mediated tumor suppression." @default.
• W2088252859 created "2016-06-24" @default.
• W2088252859 creator A5008521569 @default.
• W2088252859 creator A5021442543 @default.
• W2088252859 creator A5030789444 @default.
• W2088252859 date "2001-01-01" @default.
• W2088252859 modified "2023-10-15" @default.
• W2088252859 title "Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region" @default.
• W2088252859 cites W1749022239 @default.
• W2088252859 cites W1895938869 @default.
• W2088252859 cites W1963533810 @default.
• W2088252859 cites W1965901600 @default.
• W2088252859 cites W1966559306 @default.
• W2088252859 cites W1972009030 @default.
• W2088252859 cites W1976955696 @default.
• W2088252859 cites W1978173977 @default.
• W2088252859 cites W1986464453 @default.
• W2088252859 cites W1987399378 @default.
• W2088252859 cites W1987825597 @default.
• W2088252859 cites W1988935612 @default.
• W2088252859 cites W1989040551 @default.
• W2088252859 cites W1996015469 @default.
• W2088252859 cites W2001420623 @default.
• W2088252859 cites W2010160635 @default.
• W2088252859 cites W2031485253 @default.
• W2088252859 cites W2031514188 @default.
• W2088252859 cites W2032677592 @default.
• W2088252859 cites W2034268083 @default.
• W2088252859 cites W2061834490 @default.
• W2088252859 cites W2068555261 @default.
• W2088252859 cites W2075124527 @default.
• W2088252859 cites W2076145832 @default.
• W2088252859 cites W2076665343 @default.
• W2088252859 cites W2087841059 @default.
• W2088252859 cites W2090648810 @default.
• W2088252859 cites W2090789862 @default.
• W2088252859 cites W2105440305 @default.
• W2088252859 cites W2108366666 @default.
• W2088252859 cites W2108538978 @default.
• W2088252859 cites W2131637236 @default.
• W2088252859 cites W2132836092 @default.
• W2088252859 cites W2140496726 @default.
• W2088252859 cites W2172170481 @default.
• W2088252859 cites W2317428842 @default.
• W2088252859 cites W4297119881 @default.
• W2088252859 doi "https://doi.org/10.1002/1097-0215(20010215)91:4<457::aid-ijc1072>3.0.co;2-p" @default.
• W2088252859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11251966" @default.
• W2088252859 hasPublicationYear "2001" @default.
• W2088252859 type Work @default.
• W2088252859 sameAs 2088252859 @default.
• W2088252859 citedByCount "39" @default.
• W2088252859 countsByYear W20882528592012 @default.
• W2088252859 countsByYear W20882528592014 @default.
• W2088252859 countsByYear W20882528592015 @default.
• W2088252859 countsByYear W20882528592018 @default.
• W2088252859 countsByYear W20882528592021 @default.
• W2088252859 countsByYear W20882528592022 @default.
• W2088252859 countsByYear W20882528592023 @default.
• W2088252859 crossrefType "journal-article" @default.
• W2088252859 hasAuthorship W2088252859A5008521569 @default.
• W2088252859 hasAuthorship W2088252859A5021442543 @default.
• W2088252859 hasAuthorship W2088252859A5030789444 @default.
• W2088252859 hasConcept C104317684 @default.
• W2088252859 hasConcept C140051345 @default.
• W2088252859 hasConcept C153911025 @default.
• W2088252859 hasConcept C158617107 @default.
• W2088252859 hasConcept C181199279 @default.
• W2088252859 hasConcept C190062978 @default.
• W2088252859 hasConcept C203014093 @default.
• W2088252859 hasConcept C204232928 @default.
• W2088252859 hasConcept C25602115 @default.
• W2088252859 hasConcept C27239569 @default.
• W2088252859 hasConcept C27740335 @default.
• W2088252859 hasConcept C2776879804 @default.
• W2088252859 hasConcept C41625074 @default.
• W2088252859 hasConcept C4224716 @default.
• W2088252859 hasConcept C49805395 @default.
• W2088252859 hasConcept C55493867 @default.
• W2088252859 hasConcept C86803240 @default.
• W2088252859 hasConcept C95444343 @default.
• W2088252859 hasConcept C98539663 @default.
• W2088252859 hasConceptScore W2088252859C104317684 @default.
• W2088252859 hasConceptScore W2088252859C140051345 @default.
• W2088252859 hasConceptScore W2088252859C153911025 @default.
• W2088252859 hasConceptScore W2088252859C158617107 @default.
• W2088252859 hasConceptScore W2088252859C181199279 @default.
• W2088252859 hasConceptScore W2088252859C190062978 @default.
• W2088252859 hasConceptScore W2088252859C203014093 @default.
• W2088252859 hasConceptScore W2088252859C204232928 @default.
• W2088252859 hasConceptScore W2088252859C25602115 @default.
• W2088252859 hasConceptScore W2088252859C27239569 @default.
• W2088252859 hasConceptScore W2088252859C27740335 @default.
• W2088252859 hasConceptScore W2088252859C2776879804 @default.
• W2088252859 hasConceptScore W2088252859C41625074 @default.
• W2088252859 hasConceptScore W2088252859C4224716 @default.
• W2088252859 hasConceptScore W2088252859C49805395 @default.
• W2088252859 hasConceptScore W2088252859C55493867 @default.
• W2088252859 hasConceptScore W2088252859C86803240 @default.

• next