FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088268752> ?p ?o ?g. }

• W2088268752 endingPage "38" @default.
• W2088268752 startingPage "27" @default.
• W2088268752 abstract "Atherosclerosis is an example of a complex trait, where the course of the disease is influenced by a combination of common variation in a constellation of genes and the effect of a wide range of environmental variables. Thus, the underlying disease mechanisms will be modulated by genetic diversity and the effect this diversity has on an individual's response to environmental challenges such as smoking, diet, and exercise. Unlike the consequences of mutations in severe single-gene disorders on protein function, the impact of individual common, functionally important sequence changes in genes contributing to multifactorial diseases is likely to be very small. The challenge is to dissect the contribution that each of these genes makes to the disease process. We have tackled this by identifying common genetic variants, studying their effects on function, and applying them to the analysis of association in appropriately structured and suitably powered studies. Even with our incomplete understanding of the disease, the list of potential candidate genes we could study is vast; but, we do know from pathological studies that a wide spectrum of structural architecture exists in atherosclerotic plaques, suggesting that remodeling of vascular connective tissue is fundamentally important. Matrix remodeling is controlled by a complex network of cell and matrix interactions, the net outcome of which is the product of a balance between synthetic and degradative processes. Our work has focused on the family of enzymes and inhibitors most directly associated with matrix turnover--the matrix metalloproteinases (MMPs) and their natural inhibitors (TIMPs, tissue inhibitors of MPs). We specifically searched for functionally relevant genetic variants that might modulate the delicate control of matrix turnover. Using these molecular genetic strategies to investigate the impact of natural genetic variation on vascular matrix remodeling has begun to shed new light on the importance of these genes in atherogenesis." @default.
• W2088268752 created "2016-06-24" @default.
• W2088268752 creator A5000729930 @default.
• W2088268752 creator A5001000727 @default.
• W2088268752 creator A5010346589 @default.
• W2088268752 creator A5023822375 @default.
• W2088268752 creator A5028094654 @default.
• W2088268752 creator A5035546629 @default.
• W2088268752 creator A5066522294 @default.
• W2088268752 date "2000-05-01" @default.
• W2088268752 modified "2023-10-03" @default.
• W2088268752 title "Genetic Diversity in the Matrix Metalloproteinase Family: Effects on Function and Disease Progressiona" @default.
• W2088268752 cites W1546229037 @default.
• W2088268752 cites W1556788404 @default.
• W2088268752 cites W1894541755 @default.
• W2088268752 cites W1961781761 @default.
• W2088268752 cites W1966552057 @default.
• W2088268752 cites W1978743225 @default.
• W2088268752 cites W1980930513 @default.
• W2088268752 cites W1995440798 @default.
• W2088268752 cites W2005285972 @default.
• W2088268752 cites W2005521257 @default.
• W2088268752 cites W2010131482 @default.
• W2088268752 cites W2030176576 @default.
• W2088268752 cites W2031575410 @default.
• W2088268752 cites W2069297972 @default.
• W2088268752 cites W2083169533 @default.
• W2088268752 cites W2088023626 @default.
• W2088268752 cites W2093664978 @default.
• W2088268752 cites W2106319388 @default.
• W2088268752 cites W2115911961 @default.
• W2088268752 cites W2169095915 @default.
• W2088268752 cites W3109810545 @default.
• W2088268752 doi "https://doi.org/10.1111/j.1749-6632.2000.tb06298.x" @default.
• W2088268752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10865823" @default.
• W2088268752 hasPublicationYear "2000" @default.
• W2088268752 type Work @default.
• W2088268752 sameAs 2088268752 @default.
• W2088268752 citedByCount "27" @default.
• W2088268752 countsByYear W20882687522012 @default.
• W2088268752 countsByYear W20882687522013 @default.
• W2088268752 countsByYear W20882687522021 @default.
• W2088268752 crossrefType "journal-article" @default.
• W2088268752 hasAuthorship W2088268752A5000729930 @default.
• W2088268752 hasAuthorship W2088268752A5001000727 @default.
• W2088268752 hasAuthorship W2088268752A5010346589 @default.
• W2088268752 hasAuthorship W2088268752A5023822375 @default.
• W2088268752 hasAuthorship W2088268752A5028094654 @default.
• W2088268752 hasAuthorship W2088268752A5035546629 @default.
• W2088268752 hasAuthorship W2088268752A5066522294 @default.
• W2088268752 hasConcept C104317684 @default.
• W2088268752 hasConcept C109523444 @default.
• W2088268752 hasConcept C14036430 @default.
• W2088268752 hasConcept C142724271 @default.
• W2088268752 hasConcept C2775905019 @default.
• W2088268752 hasConcept C2779134260 @default.
• W2088268752 hasConcept C54355233 @default.
• W2088268752 hasConcept C60644358 @default.
• W2088268752 hasConcept C70721500 @default.
• W2088268752 hasConcept C71924100 @default.
• W2088268752 hasConcept C86803240 @default.
• W2088268752 hasConceptScore W2088268752C104317684 @default.
• W2088268752 hasConceptScore W2088268752C109523444 @default.
• W2088268752 hasConceptScore W2088268752C14036430 @default.
• W2088268752 hasConceptScore W2088268752C142724271 @default.
• W2088268752 hasConceptScore W2088268752C2775905019 @default.
• W2088268752 hasConceptScore W2088268752C2779134260 @default.
• W2088268752 hasConceptScore W2088268752C54355233 @default.
• W2088268752 hasConceptScore W2088268752C60644358 @default.
• W2088268752 hasConceptScore W2088268752C70721500 @default.
• W2088268752 hasConceptScore W2088268752C71924100 @default.
• W2088268752 hasConceptScore W2088268752C86803240 @default.
• W2088268752 hasIssue "1" @default.
• W2088268752 hasLocation W20882687521 @default.
• W2088268752 hasLocation W20882687522 @default.
• W2088268752 hasOpenAccess W2088268752 @default.
• W2088268752 hasPrimaryLocation W20882687521 @default.
• W2088268752 hasRelatedWork W1967535888 @default.
• W2088268752 hasRelatedWork W1991523530 @default.
• W2088268752 hasRelatedWork W2002128513 @default.
• W2088268752 hasRelatedWork W2011938312 @default.
• W2088268752 hasRelatedWork W2020824267 @default.
• W2088268752 hasRelatedWork W2171277769 @default.
• W2088268752 hasRelatedWork W4225380788 @default.
• W2088268752 hasRelatedWork W4318983165 @default.
• W2088268752 hasRelatedWork W4383711240 @default.
• W2088268752 hasRelatedWork W2092874662 @default.
• W2088268752 hasVolume "902" @default.
• W2088268752 isParatext "false" @default.
• W2088268752 isRetracted "false" @default.
• W2088268752 magId "2088268752" @default.
• W2088268752 workType "article" @default.