Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088272011> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2088272011 abstract "The majority of cyclosporine-treated transplant recipients develop hypertension. Endothelin-1 (ET-1) has been suggested to mediate cyclosporine-induced vasoconstriction when binding to ET-A receptors. We hypothesized that cyclosporine-treated lung transplant recipients have an increased basal vascular resistance and an augmented response to ET-A receptor blockade.The selective ET-A receptor blocker BQ-123 (10 and 50 nmol/min) was infused into the brachial artery, alone or in combination with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine acetate (L-NMMA) (2 and 4 micromol/min) in 10 lung transplant recipients without pharmacologically treated hypertension and 8 healthy controls. Forearm blood flow (FBF) was measured by venous occlusion plethysmography and plasma levels of ET-1 were analyzed.Baseline forearm vascular resistance did not differ between recipients and controls (32 +/- 4 vs 42 +/- 7 mmHg/ml/min, p = 0.32). BQ-123 increased FBF in controls but not in recipients (26% +/- 9% vs 5% +/- 11% at 10 nmol/min, p = 0.043 between groups). Coinfusion of BQ-123 and L-NMMA caused a comparable decrease in FBF in recipients and controls (-26% +/- 11%, vs -34% +/- 7%). Baseline ET-1 was higher in recipients (17.2 +/- 1.1 vs 14.7 +/- 0.8 pg/ml, p = 0.038). BQ-123 infusion increased plasma ET-1 in controls but not in recipients (+24% +/- 11% vs -0.4% +/- 6.2%, p = 0.029 between groups).The results demonstrate that cyclosporine-treated lung transplant recipients have increased plasma levels of ET-1 and a blunted response to ET-A receptor blockade compared with healthy subjects. In contrast, we found no evidence for an increased basal vascular resistance in transplant recipients. These alterations in endothelin handling may contribute to the development of transplant-associated hypertension." @default.
- W2088272011 created "2016-06-24" @default.
- W2088272011 creator A5000407289 @default.
- W2088272011 creator A5022604939 @default.
- W2088272011 creator A5031037993 @default.
- W2088272011 creator A5037644048 @default.
- W2088272011 creator A5075290033 @default.
- W2088272011 date "2005-06-01" @default.
- W2088272011 modified "2023-10-16" @default.
- W2088272011 title "Blunted Vascular Response to Endothelin-A Receptor Blockade in Cyclosporine-Treated Lung Transplant Recipients" @default.
- W2088272011 cites W1972305275 @default.
- W2088272011 cites W1984827528 @default.
- W2088272011 cites W1992583442 @default.
- W2088272011 cites W2002946634 @default.
- W2088272011 cites W2008966495 @default.
- W2088272011 cites W2020741324 @default.
- W2088272011 cites W2026551949 @default.
- W2088272011 cites W2051598816 @default.
- W2088272011 cites W2061720537 @default.
- W2088272011 cites W2063281374 @default.
- W2088272011 cites W2067115016 @default.
- W2088272011 cites W2071505293 @default.
- W2088272011 cites W2075025454 @default.
- W2088272011 cites W2080169345 @default.
- W2088272011 cites W2082081904 @default.
- W2088272011 cites W2082592387 @default.
- W2088272011 cites W2083240647 @default.
- W2088272011 cites W2118889864 @default.
- W2088272011 cites W2139983049 @default.
- W2088272011 cites W2162253577 @default.
- W2088272011 cites W2166338527 @default.
- W2088272011 cites W2327530331 @default.
- W2088272011 cites W2330128514 @default.
- W2088272011 cites W99752789 @default.
- W2088272011 doi "https://doi.org/10.1016/j.healun.2004.04.010" @default.
- W2088272011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15949725" @default.
- W2088272011 hasPublicationYear "2005" @default.
- W2088272011 type Work @default.
- W2088272011 sameAs 2088272011 @default.
- W2088272011 citedByCount "7" @default.
- W2088272011 crossrefType "journal-article" @default.
- W2088272011 hasAuthorship W2088272011A5000407289 @default.
- W2088272011 hasAuthorship W2088272011A5022604939 @default.
- W2088272011 hasAuthorship W2088272011A5031037993 @default.
- W2088272011 hasAuthorship W2088272011A5037644048 @default.
- W2088272011 hasAuthorship W2088272011A5075290033 @default.
- W2088272011 hasConcept C126322002 @default.
- W2088272011 hasConcept C134018914 @default.
- W2088272011 hasConcept C144980905 @default.
- W2088272011 hasConcept C149601957 @default.
- W2088272011 hasConcept C170493617 @default.
- W2088272011 hasConcept C2777604165 @default.
- W2088272011 hasConcept C2777714996 @default.
- W2088272011 hasConcept C2778024521 @default.
- W2088272011 hasConcept C2778468042 @default.
- W2088272011 hasConcept C2779306644 @default.
- W2088272011 hasConcept C2779961880 @default.
- W2088272011 hasConcept C2781448352 @default.
- W2088272011 hasConcept C58245268 @default.
- W2088272011 hasConcept C71924100 @default.
- W2088272011 hasConcept C84393581 @default.
- W2088272011 hasConcept C90924648 @default.
- W2088272011 hasConceptScore W2088272011C126322002 @default.
- W2088272011 hasConceptScore W2088272011C134018914 @default.
- W2088272011 hasConceptScore W2088272011C144980905 @default.
- W2088272011 hasConceptScore W2088272011C149601957 @default.
- W2088272011 hasConceptScore W2088272011C170493617 @default.
- W2088272011 hasConceptScore W2088272011C2777604165 @default.
- W2088272011 hasConceptScore W2088272011C2777714996 @default.
- W2088272011 hasConceptScore W2088272011C2778024521 @default.
- W2088272011 hasConceptScore W2088272011C2778468042 @default.
- W2088272011 hasConceptScore W2088272011C2779306644 @default.
- W2088272011 hasConceptScore W2088272011C2779961880 @default.
- W2088272011 hasConceptScore W2088272011C2781448352 @default.
- W2088272011 hasConceptScore W2088272011C58245268 @default.
- W2088272011 hasConceptScore W2088272011C71924100 @default.
- W2088272011 hasConceptScore W2088272011C84393581 @default.
- W2088272011 hasConceptScore W2088272011C90924648 @default.
- W2088272011 hasLocation W20882720111 @default.
- W2088272011 hasLocation W20882720112 @default.
- W2088272011 hasOpenAccess W2088272011 @default.
- W2088272011 hasPrimaryLocation W20882720111 @default.
- W2088272011 hasRelatedWork W2005378862 @default.
- W2088272011 hasRelatedWork W2008157745 @default.
- W2088272011 hasRelatedWork W2017652955 @default.
- W2088272011 hasRelatedWork W2020741324 @default.
- W2088272011 hasRelatedWork W2056307850 @default.
- W2088272011 hasRelatedWork W2088272011 @default.
- W2088272011 hasRelatedWork W2118889864 @default.
- W2088272011 hasRelatedWork W2125122609 @default.
- W2088272011 hasRelatedWork W2141307244 @default.
- W2088272011 hasRelatedWork W4241967195 @default.
- W2088272011 isParatext "false" @default.
- W2088272011 isRetracted "false" @default.
- W2088272011 magId "2088272011" @default.
- W2088272011 workType "article" @default.