FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088287002> ?p ?o ?g. }

• W2088287002 abstract "Tissue adhesives are useful means for various medical procedures. Since varying requirements cause that a single adhesive cannot meet all needs, bond strength testing remains one of the key applications used to screen for new products and study the influence of experimental variables. This study was conducted to develop an easy to use method to screen and evaluate tissue adhesives for tissue engineering applications. Tissue grips were designed to facilitate the reproducible production of substrate tissue and adhesive strength measurements in universal testing machines. Porcine femoral condyles were used to generate osteochondral test tissue cylinders (substrates) of different shapes. Viability of substrates was tested using PI/FDA staining. Self-bonding properties were determined to examine reusability of substrates (n = 3). Serial measurements (n = 5) in different operation modes (OM) were performed to analyze the bonding strength of tissue adhesives in bone (OM-1) and cartilage tissue either in isolation (OM-2) or under specific requirements in joint repair such as filling cartilage defects with clinical applied fibrin/PLGA-cell-transplants (OM-3) or tissues (OM-4). The efficiency of the method was determined on the basis of adhesive properties of fibrin glue for different assembly times (30 s, 60 s). Seven randomly generated collagen formulations were analyzed to examine the potential of method to identify new tissue adhesives. Viability analysis of test tissue cylinders revealed vital cells (>80%) in cartilage components even 48 h post preparation. Reuse (n = 10) of test substrate did not significantly change adhesive characteristics. Adhesive strength of fibrin varied in different test settings (OM-1: 7.1 kPa, OM-2: 2.6 kPa, OM-3: 32.7 kPa, OM-4: 30.1 kPa) and was increasing with assembly time on average (2.4-fold). The screening of the different collagen formulations revealed a substance with significant higher adhesive strength on cartilage (14.8 kPa) and bone tissue (11.8 kPa) compared to fibrin and also considerable adhesive properties when filling defects with cartilage tissue (23.2 kPa). The method confirmed adhesive properties of fibrin and demonstrated the dependence of adhesive properties and applied settings. Furthermore the method was suitable to screen for potential adhesives and to identify a promising candidate for cartilage and bone applications. The method can offer simple, replicable and efficient evaluation of adhesive properties in ex vivo specimens and may be a useful supplement to existing methods in clinical relevant settings." @default.
• W2088287002 created "2016-06-24" @default.
• W2088287002 creator A5007869667 @default.
• W2088287002 creator A5028238778 @default.
• W2088287002 creator A5038061458 @default.
• W2088287002 creator A5050264430 @default.
• W2088287002 creator A5055994992 @default.
• W2088287002 creator A5070684401 @default.
• W2088287002 creator A5078384850 @default.
• W2088287002 creator A5084010065 @default.
• W2088287002 date "2012-09-17" @default.
• W2088287002 modified "2023-10-18" @default.
• W2088287002 title "A method to screen and evaluate tissue adhesives for joint repair applications" @default.
• W2088287002 cites W1971163308 @default.
• W2088287002 cites W1991776465 @default.
• W2088287002 cites W2008750339 @default.
• W2088287002 cites W2018917462 @default.
• W2088287002 cites W2036493028 @default.
• W2088287002 cites W2044308450 @default.
• W2088287002 cites W2048952988 @default.
• W2088287002 cites W2060015278 @default.
• W2088287002 cites W2062671008 @default.
• W2088287002 cites W2072570382 @default.
• W2088287002 cites W2074868036 @default.
• W2088287002 cites W2081891654 @default.
• W2088287002 cites W2098557080 @default.
• W2088287002 cites W2117582266 @default.
• W2088287002 cites W2120598009 @default.
• W2088287002 cites W2141819286 @default.
• W2088287002 cites W2164143250 @default.
• W2088287002 cites W2172710605 @default.
• W2088287002 cites W2172858724 @default.
• W2088287002 doi "https://doi.org/10.1186/1471-2474-13-175" @default.
• W2088287002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732078" @default.
• W2088287002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22984926" @default.
• W2088287002 hasPublicationYear "2012" @default.
• W2088287002 type Work @default.
• W2088287002 sameAs 2088287002 @default.
• W2088287002 citedByCount "13" @default.
• W2088287002 countsByYear W20882870022014 @default.
• W2088287002 countsByYear W20882870022016 @default.
• W2088287002 countsByYear W20882870022017 @default.
• W2088287002 countsByYear W20882870022018 @default.
• W2088287002 countsByYear W20882870022019 @default.
• W2088287002 countsByYear W20882870022021 @default.
• W2088287002 countsByYear W20882870022022 @default.
• W2088287002 countsByYear W20882870022023 @default.
• W2088287002 crossrefType "journal-article" @default.
• W2088287002 hasAuthorship W2088287002A5007869667 @default.
• W2088287002 hasAuthorship W2088287002A5028238778 @default.
• W2088287002 hasAuthorship W2088287002A5038061458 @default.
• W2088287002 hasAuthorship W2088287002A5050264430 @default.
• W2088287002 hasAuthorship W2088287002A5055994992 @default.
• W2088287002 hasAuthorship W2088287002A5070684401 @default.
• W2088287002 hasAuthorship W2088287002A5078384850 @default.
• W2088287002 hasAuthorship W2088287002A5084010065 @default.
• W2088287002 hasBestOaLocation W20882870021 @default.
• W2088287002 hasConcept C105702510 @default.
• W2088287002 hasConcept C136229726 @default.
• W2088287002 hasConcept C141071460 @default.
• W2088287002 hasConcept C159985019 @default.
• W2088287002 hasConcept C192562407 @default.
• W2088287002 hasConcept C2775883587 @default.
• W2088287002 hasConcept C2778171257 @default.
• W2088287002 hasConcept C2779227376 @default.
• W2088287002 hasConcept C2780550940 @default.
• W2088287002 hasConcept C2781472170 @default.
• W2088287002 hasConcept C2910882873 @default.
• W2088287002 hasConcept C49892992 @default.
• W2088287002 hasConcept C68928338 @default.
• W2088287002 hasConcept C71924100 @default.
• W2088287002 hasConceptScore W2088287002C105702510 @default.
• W2088287002 hasConceptScore W2088287002C136229726 @default.
• W2088287002 hasConceptScore W2088287002C141071460 @default.
• W2088287002 hasConceptScore W2088287002C159985019 @default.
• W2088287002 hasConceptScore W2088287002C192562407 @default.
• W2088287002 hasConceptScore W2088287002C2775883587 @default.
• W2088287002 hasConceptScore W2088287002C2778171257 @default.
• W2088287002 hasConceptScore W2088287002C2779227376 @default.
• W2088287002 hasConceptScore W2088287002C2780550940 @default.
• W2088287002 hasConceptScore W2088287002C2781472170 @default.
• W2088287002 hasConceptScore W2088287002C2910882873 @default.
• W2088287002 hasConceptScore W2088287002C49892992 @default.
• W2088287002 hasConceptScore W2088287002C68928338 @default.
• W2088287002 hasConceptScore W2088287002C71924100 @default.
• W2088287002 hasIssue "1" @default.
• W2088287002 hasLocation W20882870021 @default.
• W2088287002 hasLocation W20882870022 @default.
• W2088287002 hasLocation W20882870023 @default.
• W2088287002 hasLocation W20882870024 @default.
• W2088287002 hasOpenAccess W2088287002 @default.
• W2088287002 hasPrimaryLocation W20882870021 @default.
• W2088287002 hasRelatedWork W120312027 @default.
• W2088287002 hasRelatedWork W172058065 @default.
• W2088287002 hasRelatedWork W2021152648 @default.
• W2088287002 hasRelatedWork W2088287002 @default.
• W2088287002 hasRelatedWork W2147162557 @default.
• W2088287002 hasRelatedWork W2162374295 @default.
• W2088287002 hasRelatedWork W2365223900 @default.
• W2088287002 hasRelatedWork W2381875782 @default.

• next