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• W2088295233 abstract "A three-dimensional multiscale computational model, platelet adhesive dynamics (PAD), is developed and applied in Part I and Part II articles to characterize and quantify key biophysical aspects of GPIbα-von-Willebrand-factor (vWF)-mediated interplatelet binding at high shear rates, a necessary and enabling step that initiates shear-induced platelet aggregation. In this article, an adhesive dynamics model of the transient aggregation of two unactivated platelets via GPIbα-vWF-GPIbα bridging is developed and integrated with the three-dimensional hydrodynamic flow model discussed in Part I. Platelet binding efficiencies predicted by PAD are in good agreement with platelet aggregation behavior observed experimentally, as documented in the literature. Deviations from average vWF ligand size or healthy GPIbα-vWF-A1 binding kinetics are observed in simulations to have significant effects on the dynamics of transient platelet aggregation, i.e., the efficiency of platelet aggregation and characteristics of bond failure, in ways that typify diseased conditions. The GPIbα-vWF-A1 bond formation rate is predicted to have piecewise linear dependence on the prevailing fluid shear rate, with a sharp transition in fluid shear dependency at 7200 s−1. Interplatelet bond force-loading is found to be complex and highly nonlinear. These results demonstrate PAD as a powerful predictive modeling tool for elucidating platelet adhesive phenomena under flow." @default.
• W2088295233 created "2016-06-24" @default.
• W2088295233 creator A5006299776 @default.
• W2088295233 creator A5081005464 @default.
• W2088295233 date "2008-09-01" @default.
• W2088295233 modified "2023-10-02" @default.
• W2088295233 title "Platelet Adhesive Dynamics. Part II: High Shear-Induced Transient Aggregation via GPIbα-vWF-GPIbα Bridging" @default.
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• W2088295233 doi "https://doi.org/10.1529/biophysj.107.128520" @default.
• W2088295233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2517035" @default.
• W2088295233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18515386" @default.
• W2088295233 hasPublicationYear "2008" @default.
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