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- W2088302007 abstract "Vitamin K is a trace nutrient necessary not only for the synthesis of four plasma clotting factors but also the production of two important anticlotting factors, protein C and protein S, and the synthesis of two bone proteins. If protein C and protein S are produced more quickly and/or in higher quantities than four plasma coagulation factors after vitamin K administration, then the result is unfavorable for stopping of hemorrhage. We therefore studied the difference of time dependence of prothrombin procoagulant factors, protein C and S and bone Gla protein after the administration of vitamin K in normal and vitamin K-deficient neonates. Results of our study showed that, on the whole, coagulation factors increased markedly more than anticlotting factors after vitamin K administration. Furthermore, the increase in bone Gla protein was also higher compared with protein C activity, although the detailed mechanism of the difference in reactivity of prothrombin procoagulant factors, protein C and S and bone Gla protein to vitamin K administration is not clear." @default.
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- W2088302007 date "2000-01-01" @default.
- W2088302007 modified "2023-10-16" @default.
- W2088302007 title "Differences in Reactivity to Vitamin K Administration of the Vitamin K-Dependent Procoagulant Factors, Protein C and S, and Osteocalcin" @default.
- W2088302007 doi "https://doi.org/10.1055/s-2000-9814" @default.
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