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• W2088307639 startingPage "813" @default.
• W2088307639 abstract "The L1 (LINE 1) retrotransposable element encodes two proteins, ORF1p and ORF2p. ORF2p is the L1 replicase, but the role of ORF1p is unknown. Mouse ORF1p, a coiled-coil-mediated trimer of ∼42-kDa monomers, binds nucleic acids and has nucleic acid chaperone activity. We purified human L1 ORF1p expressed in insect cells and made two findings that significantly advance our knowledge of the protein. First, in the absence of nucleic acids, the protein polymerizes under the very conditions (0.05 M NaCl) that are optimal for high (∼1 nM)-affinity nucleic acid binding. The non-coiled-coil C-terminal half mediates formation of the polymer, an active conformer that is instantly resolved to trimers, or multimers thereof, by nucleic acid. Second, the protein has a biphasic effect on mismatched double-stranded DNA, a proxy chaperone substrate. It protects the duplex from dissociation at 37°C before eventually melting it when largely polymeric. Therefore, polymerization of ORF1p seemingly affects its interaction with nucleic acids. Additionally, polymerization of ORF1p at its translation site could explain the heretofore-inexplicable phenomenon of cis preference—the favored retrotransposition of the actively translated L1 transcript, which is essential for L1 survival." @default.
• W2088307639 created "2016-06-24" @default.
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• W2088307639 date "2011-09-21" @default.
• W2088307639 modified "2023-09-26" @default.
• W2088307639 title "Polymerization and nucleic acid-binding properties of human L1 ORF1 protein" @default.
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• W2088307639 doi "https://doi.org/10.1093/nar/gkr728" @default.
• W2088307639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3258132" @default.
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• W2088307639 hasPublicationYear "2011" @default.
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