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• W2088331424 abstract "Cu/Zn SOD1G93A transgenic mice develop phenotypical hallmarks of ALS and serve therefore as an established model to study the molecular mechanisms underlying this disease. Recent reports demonstrate that mutations in the motor protein dynein in Legs at odd angles (Loa) and Cramping (Cra1) mice lead to similar but milder phenotypes. Surprisingly, double transgenic mice (Loa/SOD1G93A) have been recently shown to attenuate rather than to accelerate the phenotypical expression of motor neuron degeneration. These results raise the question whether other functional relevant mutations in dynein cause a similar effect. To address this question, we have cross-bred SOD1G93A with Cra1/+ mice. These double transgenic mice show an attenuated decline of both motor activity and body weight and an increase of survival time compared to SOD1G93A mice. Thus, this study confirms that mechanisms associated with dynein such as retrograde axonal transport may play an important role in SOD1G93A− toxicity on motor neurons." @default.
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• W2088331424 date "2006-03-01" @default.
• W2088331424 modified "2023-09-27" @default.
• W2088331424 title "A dynein mutation attenuates motor neuron degeneration in SOD1G93A mice" @default.
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• W2088331424 doi "https://doi.org/10.1016/j.expneurol.2005.12.005" @default.
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