FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088332198> ?p ?o ?g. }

• W2088332198 endingPage "521" @default.
• W2088332198 startingPage "517" @default.
• W2088332198 abstract "Primary hyperparathyroidism (HPT) is the leading cause of hypercalcemia in the outpatient setting, and it is treated primarily by parathyroidectomy. There are few nonsurgical treatment options for patients who do not wish to have surgery, who have failed surgery, or who have contraindications to surgery. Cinacalcet increases the sensitivity of parathyroid calcium-sensing receptors to extracellular calcium, thereby reducing serum calcium levels. We conducted a retrospective chart review from 2004 to 2006 to investigate the efficacy of cinacalcet in reducing serum total calcium, ionized calcium, and parathyroid hormone (PTH) in patients with primary HPT. Patients were started on cinacalcet if they met at least one indication for parathyroidectomy, which includes T score less than -2.5 standard deviations from the mean, serum calcium 1 mg/dL above the upper limit of normal, 24-hour urine calcium above 400 mg/dL, age less than 50 years, or a creatinine clearance that is 30% below age- and sex-matched controls. The primary outcome was normalization of serum calcium. A total of 18 patients with primary HPT were started on cinacalcet: 16 men and 2 women with a mean age of 70 years. Mean baseline serum calcium was 10.60 +/- .53 mg/dL; ionized serum calcium, 1.45 +/- .07 mmol/L; and serum PTH, 141 +/- 78 pg/mL. After treatment with cinacalcet, the mean serum calcium decreased to 9.46 +/- .34 mg/dL, ionized calcium decreased to 1.26 +/- .06 mmol/L, and PTH decreased to 108 +/- 64.5 pg/mL. Ninety-four percent of the patients on cinacalcet had normal total serum calcium, 81% had normal serum ionized calcium, whereas only 25% had a normal serum PTH level. Cinacalcet normalizes serum calcium in most patients while only modestly reducing serum PTH levels." @default.
• W2088332198 created "2016-06-24" @default.
• W2088332198 creator A5002769962 @default.
• W2088332198 creator A5005459931 @default.
• W2088332198 creator A5087352271 @default.
• W2088332198 date "2008-04-01" @default.
• W2088332198 modified "2023-09-28" @default.
• W2088332198 title "Cinacalcet for the treatment of primary hyperparathyroidism" @default.
• W2088332198 cites W1970517193 @default.
• W2088332198 cites W2002351078 @default.
• W2088332198 cites W2014313472 @default.
• W2088332198 cites W2016622147 @default.
• W2088332198 cites W2020113028 @default.
• W2088332198 cites W2021809848 @default.
• W2088332198 cites W2036976619 @default.
• W2088332198 cites W2038261146 @default.
• W2088332198 cites W2042961790 @default.
• W2088332198 cites W2046598957 @default.
• W2088332198 cites W2064584518 @default.
• W2088332198 cites W2084039621 @default.
• W2088332198 cites W2086695519 @default.
• W2088332198 cites W2088244676 @default.
• W2088332198 cites W2113108574 @default.
• W2088332198 cites W2124835329 @default.
• W2088332198 cites W2143878967 @default.
• W2088332198 cites W2313541363 @default.
• W2088332198 cites W2322147818 @default.
• W2088332198 cites W2323791931 @default.
• W2088332198 cites W2326660924 @default.
• W2088332198 cites W4232052338 @default.
• W2088332198 cites W4237538204 @default.
• W2088332198 cites W4241764497 @default.
• W2088332198 cites W4376999369 @default.
• W2088332198 doi "https://doi.org/10.1016/j.metabol.2007.11.014" @default.
• W2088332198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18328354" @default.
• W2088332198 hasPublicationYear "2008" @default.
• W2088332198 type Work @default.
• W2088332198 sameAs 2088332198 @default.
• W2088332198 citedByCount "37" @default.
• W2088332198 countsByYear W20883321982012 @default.
• W2088332198 countsByYear W20883321982013 @default.
• W2088332198 countsByYear W20883321982014 @default.
• W2088332198 countsByYear W20883321982015 @default.
• W2088332198 countsByYear W20883321982016 @default.
• W2088332198 countsByYear W20883321982017 @default.
• W2088332198 countsByYear W20883321982018 @default.
• W2088332198 countsByYear W20883321982020 @default.
• W2088332198 countsByYear W20883321982022 @default.
• W2088332198 countsByYear W20883321982023 @default.
• W2088332198 crossrefType "journal-article" @default.
• W2088332198 hasAuthorship W2088332198A5002769962 @default.
• W2088332198 hasAuthorship W2088332198A5005459931 @default.
• W2088332198 hasAuthorship W2088332198A5087352271 @default.
• W2088332198 hasConcept C126322002 @default.
• W2088332198 hasConcept C126894567 @default.
• W2088332198 hasConcept C134018914 @default.
• W2088332198 hasConcept C2775945674 @default.
• W2088332198 hasConcept C2777645128 @default.
• W2088332198 hasConcept C2778838027 @default.
• W2088332198 hasConcept C2779053571 @default.
• W2088332198 hasConcept C2780306776 @default.
• W2088332198 hasConcept C2780534505 @default.
• W2088332198 hasConcept C2781208988 @default.
• W2088332198 hasConcept C519063684 @default.
• W2088332198 hasConcept C71924100 @default.
• W2088332198 hasConcept C87975464 @default.
• W2088332198 hasConcept C90924648 @default.
• W2088332198 hasConceptScore W2088332198C126322002 @default.
• W2088332198 hasConceptScore W2088332198C126894567 @default.
• W2088332198 hasConceptScore W2088332198C134018914 @default.
• W2088332198 hasConceptScore W2088332198C2775945674 @default.
• W2088332198 hasConceptScore W2088332198C2777645128 @default.
• W2088332198 hasConceptScore W2088332198C2778838027 @default.
• W2088332198 hasConceptScore W2088332198C2779053571 @default.
• W2088332198 hasConceptScore W2088332198C2780306776 @default.
• W2088332198 hasConceptScore W2088332198C2780534505 @default.
• W2088332198 hasConceptScore W2088332198C2781208988 @default.
• W2088332198 hasConceptScore W2088332198C519063684 @default.
• W2088332198 hasConceptScore W2088332198C71924100 @default.
• W2088332198 hasConceptScore W2088332198C87975464 @default.
• W2088332198 hasConceptScore W2088332198C90924648 @default.
• W2088332198 hasIssue "4" @default.
• W2088332198 hasLocation W20883321981 @default.
• W2088332198 hasLocation W20883321982 @default.
• W2088332198 hasOpenAccess W2088332198 @default.
• W2088332198 hasPrimaryLocation W20883321981 @default.
• W2088332198 hasRelatedWork W1966238058 @default.
• W2088332198 hasRelatedWork W1975438252 @default.
• W2088332198 hasRelatedWork W1986416045 @default.
• W2088332198 hasRelatedWork W1987877535 @default.
• W2088332198 hasRelatedWork W1989517281 @default.
• W2088332198 hasRelatedWork W2023088314 @default.
• W2088332198 hasRelatedWork W2088332198 @default.
• W2088332198 hasRelatedWork W2092968079 @default.
• W2088332198 hasRelatedWork W2133709292 @default.
• W2088332198 hasRelatedWork W2326660924 @default.
• W2088332198 hasVolume "57" @default.
• W2088332198 isParatext "false" @default.

• next