Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088333502> ?p ?o ?g. }
- W2088333502 endingPage "65" @default.
- W2088333502 startingPage "49" @default.
- W2088333502 abstract "The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here, we describe a novel mechanism relating to the regulatory role of Neutrophil Gelatinase Associated Lipocalin (NGAL) in modulating the levels of autoantibodies in pristane induced lupus. Following a single injection of pristane intraperitoneally, NGAL expression was induced in both the serum and spleen. Furthermore, NGAL deficient mice were more susceptible to the induction of pristane stimulated autoimmunity, and displayed higher numbers of autoantibody secreting cells and increased expression of activation induced cytidine deaminase (AID) and other inflammatory mediators in the spleen. In contrast, kidney damage was milder in NGAL deficient mice, indicating that NGAL was detrimental in autoantibody mediated kidney disease. These studies indicate that NGAL plays differential roles in different tissues in the context of lupus, and suggest a previously unrecognized role for NGAL in adaptive immunity." @default.
- W2088333502 created "2016-06-24" @default.
- W2088333502 creator A5029479045 @default.
- W2088333502 creator A5036519472 @default.
- W2088333502 creator A5046223338 @default.
- W2088333502 creator A5046874707 @default.
- W2088333502 creator A5055090130 @default.
- W2088333502 creator A5078972851 @default.
- W2088333502 creator A5088498253 @default.
- W2088333502 date "2014-09-01" @default.
- W2088333502 modified "2023-10-18" @default.
- W2088333502 title "Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin" @default.
- W2088333502 cites W1484813060 @default.
- W2088333502 cites W1537587697 @default.
- W2088333502 cites W1565375494 @default.
- W2088333502 cites W1573072168 @default.
- W2088333502 cites W1574315642 @default.
- W2088333502 cites W1577362137 @default.
- W2088333502 cites W1710938496 @default.
- W2088333502 cites W1880840061 @default.
- W2088333502 cites W1893091919 @default.
- W2088333502 cites W1898659608 @default.
- W2088333502 cites W1900142034 @default.
- W2088333502 cites W1909153838 @default.
- W2088333502 cites W1919092568 @default.
- W2088333502 cites W1957540688 @default.
- W2088333502 cites W1957752652 @default.
- W2088333502 cites W1968595448 @default.
- W2088333502 cites W1968712129 @default.
- W2088333502 cites W1974866235 @default.
- W2088333502 cites W1981866304 @default.
- W2088333502 cites W1984242910 @default.
- W2088333502 cites W1991133811 @default.
- W2088333502 cites W2001370885 @default.
- W2088333502 cites W2003346334 @default.
- W2088333502 cites W2005719119 @default.
- W2088333502 cites W2009795423 @default.
- W2088333502 cites W2013522744 @default.
- W2088333502 cites W2014243721 @default.
- W2088333502 cites W2020393858 @default.
- W2088333502 cites W2021234688 @default.
- W2088333502 cites W2029499211 @default.
- W2088333502 cites W2035718151 @default.
- W2088333502 cites W2037398275 @default.
- W2088333502 cites W2041736631 @default.
- W2088333502 cites W2043526660 @default.
- W2088333502 cites W2045355153 @default.
- W2088333502 cites W2046530746 @default.
- W2088333502 cites W2050169698 @default.
- W2088333502 cites W2051515223 @default.
- W2088333502 cites W2061261440 @default.
- W2088333502 cites W2063413550 @default.
- W2088333502 cites W2065326187 @default.
- W2088333502 cites W2071646381 @default.
- W2088333502 cites W2074692187 @default.
- W2088333502 cites W2079796469 @default.
- W2088333502 cites W2084235654 @default.
- W2088333502 cites W2086943252 @default.
- W2088333502 cites W2088120033 @default.
- W2088333502 cites W2094463157 @default.
- W2088333502 cites W2094773688 @default.
- W2088333502 cites W2096137281 @default.
- W2088333502 cites W2101494871 @default.
- W2088333502 cites W2102891732 @default.
- W2088333502 cites W2103425125 @default.
- W2088333502 cites W2103982494 @default.
- W2088333502 cites W2106610000 @default.
- W2088333502 cites W2107398177 @default.
- W2088333502 cites W2109977280 @default.
- W2088333502 cites W2115375944 @default.
- W2088333502 cites W2118495715 @default.
- W2088333502 cites W2120859412 @default.
- W2088333502 cites W2122327137 @default.
- W2088333502 cites W2122934045 @default.
- W2088333502 cites W2125173446 @default.
- W2088333502 cites W2125867015 @default.
- W2088333502 cites W2126780894 @default.
- W2088333502 cites W2128830838 @default.
- W2088333502 cites W2137234819 @default.
- W2088333502 cites W2140374361 @default.
- W2088333502 cites W2143271832 @default.
- W2088333502 cites W2145240148 @default.
- W2088333502 cites W2149840720 @default.
- W2088333502 cites W2150952999 @default.
- W2088333502 cites W2152863656 @default.
- W2088333502 cites W2160276873 @default.
- W2088333502 cites W2164808276 @default.
- W2088333502 cites W2169432046 @default.
- W2088333502 cites W2260292839 @default.
- W2088333502 cites W4313422280 @default.
- W2088333502 doi "https://doi.org/10.1016/j.clim.2014.06.007" @default.
- W2088333502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4119527" @default.
- W2088333502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24971701" @default.
- W2088333502 hasPublicationYear "2014" @default.
- W2088333502 type Work @default.
- W2088333502 sameAs 2088333502 @default.
- W2088333502 citedByCount "14" @default.
- W2088333502 countsByYear W20883335022015 @default.