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• W2088335765 abstract "Ten compounds, neopulchellin (1), 6α- hydroxyneopulchellin (2), β-sitosterol-3-O-β-D-glucoside (3), apigenin (4), quercitin (5), eupafolin (6), kaempferol-3-methoxy-7-O-α-L-rhamnoside (7), apigenin-7-O-β-D-glucopyranoside (8), α-amyrin (9) and β-sitosterol (10), were isolated from the leaves of Gaillardia aristata by applying bioassay guided fractionation. The cytotoxicity was traced against two human cancer cell lines (breast (MCF7) and colon (HCT116)). The highest cytotoxicity was revealed by compounds 1 and 2 (isolated from chloroform extract); with IC(50) values of 0.43, 0.32 µg mL(-1) against MCF7 and 0.46, 0.34 µg mL(-1) against HCT116, respectively. Compounds 9 and 10 (isolated from the n-hexane extract) exhibited lower IC(50) values of 3.05, 2.35 µg mL(-1) against MCF7 and 3.05, 2.35 µg mL(-1) against HCT116, respectively, while compounds 4-7 obtained from the ethyl acetate extract revealed the lowest cytotoxicity. Identification of the aforementioned compounds was carried out on the basis of their physico-chemical properties and spectral analysis (UV, EI/MS, 1D and 2D)." @default.
• W2088335765 created "2016-06-24" @default.
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• W2088335765 date "2011-08-17" @default.
• W2088335765 modified "2023-09-27" @default.
• W2088335765 title "Cytotoxic compounds from the leaves ofGaillardia aristataPursh. growing in Egypt" @default.
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• W2088335765 doi "https://doi.org/10.1080/14786419.2011.606219" @default.
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