FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088338085> ?p ?o ?g. }

• W2088338085 endingPage "130" @default.
• W2088338085 startingPage "113" @default.
• W2088338085 abstract "The pathogenesis of peripheral blood cytopenias in AIDS patients is clearly multifactorial. Among the various contributing mechanisms, those involving a direct role of HIV-1 have been actively investigated in the past few years. It has now been convincingly demonstrated that HIV can impair the survival/proliferative capacity of purified haematopoietic progenitor cells. Although a subset of haematopoietic progenitor cells are perhaps susceptible to HIV-1 infection, both in vitro and in vivo, the suppressive effect does not require either active or latent infection and is probably mediated by the interaction of viral or virus-associated proteins with the cell membrane of haematopoietic progenitor cells. Both the viral load and the biological characteristics of the virus play an important role in suppression, since different isolates displayed different inhibitory activity. Haematosuppression is not a specific property of monocytotropic versus lymphocytotropic or low-replicating versus high-replicating isolates, and it will be important to exactly establish which viral component is crucial to suppression of haematopoietic progenitor cells. Since the haematopoietic stem cell is the common progenitor to both the myeloid and lymphoid lineages, the capacity of HIV to impair the growth of early haematopoietic progenitor cells could contribute not only to the frequent occurrence of anaemia, granulocytopenia and thrombocytopenia in AIDS patients, but also to the inability of the bone marrow to reconstitute a functional pool of mature CD4+ T-cells. It is also possible that haematopoietic progenitor cells committed to the T-lymphoid lineage are impaired by HIV in their differential pathway within the thymus (Bonyhadi et al, 1993). Infection of megakaryocytes could result in underproduction of platelets and possibly represents a major pathogenetic mechanism of HIV-related thrombocytopenia. Infection of monocytes and T-lymphocytes leads in vitro and probably also in vivo to deranged cytokine production. In the first stages of the disease, increased cytokine production, consequent to a chronic immune activation, is probably responsible for the myelodysplastic/hyperplastic alterations observed at the bone marrow level. In more advanced stages of the disease, the general decline in immune function, the consequent imbalance in cytokine production, and the increase in viral burden, may contribute to dysregulated haematopoiesis and peripheral blood cytopenias." @default.
• W2088338085 created "2016-06-24" @default.
• W2088338085 creator A5043662372 @default.
• W2088338085 creator A5059527919 @default.
• W2088338085 date "1995-03-01" @default.
• W2088338085 modified "2023-09-24" @default.
• W2088338085 title "5 Effect of human immunodeficiency virus infection on haematopoiesis" @default.
• W2088338085 cites W1507250903 @default.
• W2088338085 cites W1519144004 @default.
• W2088338085 cites W1592374520 @default.
• W2088338085 cites W1599962408 @default.
• W2088338085 cites W1604626968 @default.
• W2088338085 cites W1752108741 @default.
• W2088338085 cites W1966120231 @default.
• W2088338085 cites W1967041200 @default.
• W2088338085 cites W1977665434 @default.
• W2088338085 cites W1979989842 @default.
• W2088338085 cites W1984511547 @default.
• W2088338085 cites W1994604760 @default.
• W2088338085 cites W1997169389 @default.
• W2088338085 cites W1998421163 @default.
• W2088338085 cites W1999939167 @default.
• W2088338085 cites W1999965933 @default.
• W2088338085 cites W2000137099 @default.
• W2088338085 cites W2000791973 @default.
• W2088338085 cites W2003847492 @default.
• W2088338085 cites W2005788336 @default.
• W2088338085 cites W2011625552 @default.
• W2088338085 cites W2017345241 @default.
• W2088338085 cites W2017916477 @default.
• W2088338085 cites W2022852420 @default.
• W2088338085 cites W2022854476 @default.
• W2088338085 cites W2025356375 @default.
• W2088338085 cites W2026500374 @default.
• W2088338085 cites W2036890038 @default.
• W2088338085 cites W2037210754 @default.
• W2088338085 cites W2043837850 @default.
• W2088338085 cites W2064914230 @default.
• W2088338085 cites W2065114401 @default.
• W2088338085 cites W2072863715 @default.
• W2088338085 cites W2074734171 @default.
• W2088338085 cites W2075135942 @default.
• W2088338085 cites W2079335891 @default.
• W2088338085 cites W2083735950 @default.
• W2088338085 cites W2091139672 @default.
• W2088338085 cites W2099787406 @default.
• W2088338085 cites W2128083417 @default.
• W2088338085 cites W2139113838 @default.
• W2088338085 cites W2161045200 @default.
• W2088338085 cites W2170206314 @default.
• W2088338085 cites W2230544711 @default.
• W2088338085 cites W2258659648 @default.
• W2088338085 cites W226476106 @default.
• W2088338085 cites W2317605718 @default.
• W2088338085 cites W2318770038 @default.
• W2088338085 cites W2320150009 @default.
• W2088338085 cites W2321301970 @default.
• W2088338085 cites W2334837504 @default.
• W2088338085 cites W2336115893 @default.
• W2088338085 cites W2342596370 @default.
• W2088338085 cites W2398146302 @default.
• W2088338085 cites W2409811498 @default.
• W2088338085 cites W2412785121 @default.
• W2088338085 cites W2416946457 @default.
• W2088338085 cites W2462427044 @default.
• W2088338085 cites W291798906 @default.
• W2088338085 cites W346035305 @default.
• W2088338085 cites W4243233723 @default.
• W2088338085 cites W4249129130 @default.
• W2088338085 cites W4252664596 @default.
• W2088338085 cites W71452661 @default.
• W2088338085 doi "https://doi.org/10.1016/s0950-3536(05)80234-3" @default.
• W2088338085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7545035" @default.
• W2088338085 hasPublicationYear "1995" @default.
• W2088338085 type Work @default.
• W2088338085 sameAs 2088338085 @default.
• W2088338085 citedByCount "39" @default.
• W2088338085 countsByYear W20883380852012 @default.
• W2088338085 countsByYear W20883380852013 @default.
• W2088338085 countsByYear W20883380852014 @default.
• W2088338085 countsByYear W20883380852017 @default.
• W2088338085 countsByYear W20883380852020 @default.
• W2088338085 countsByYear W20883380852022 @default.
• W2088338085 crossrefType "journal-article" @default.
• W2088338085 hasAuthorship W2088338085A5043662372 @default.
• W2088338085 hasAuthorship W2088338085A5059527919 @default.
• W2088338085 hasConcept C109159458 @default.
• W2088338085 hasConcept C15729860 @default.
• W2088338085 hasConcept C159047783 @default.
• W2088338085 hasConcept C201750760 @default.
• W2088338085 hasConcept C203014093 @default.
• W2088338085 hasConcept C2522874641 @default.
• W2088338085 hasConcept C2779282312 @default.
• W2088338085 hasConcept C2780007613 @default.
• W2088338085 hasConcept C28328180 @default.
• W2088338085 hasConcept C86803240 @default.
• W2088338085 hasConcept C95444343 @default.
• W2088338085 hasConceptScore W2088338085C109159458 @default.

• next