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- W2088348503 abstract "A collagenase proenzyme was found in crude human leucocyte extract. An activating agent was present in all the ten studied rheumatoid synovial fluids taken from knee joints. The activator was found to be heat labile and nondialyzable. Activation occurred after mixing crude extract with synovial fluid (protein ratio 1:1) and heating the mixture for several hours at 37°C. Collagenase was produced from proenzyme both when the activator acted on the crude leucocyte extract and when it acted on the same extract previously devoid of free collagenase; however, activation did not occur in crude extracts partially purified with dioxan. The amount of proenzyme in the extract was about 3 times greater than that of free collagenase. Activated proenzyme was capable of releasing soluble hydroxyproline peptides from reconstituted collagen fibrils at 37°C, and of decreasing the viscosity of collagen in solution at 26°C. Both the activated proenzyme and the free collagenase from leucocytes produced the same degradation products from soluble native collagen. An alternative possibility, that the activator was present in crude extract and the proenzyme in synovial fluid, was experimentally ruled out. The role of collagenase proenzyme from leucocytes in the inflamatory state of tissues is discussed." @default.
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- W2088348503 date "1972-12-01" @default.
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- W2088348503 title "Activation of leucocyte collagenase proenzyme by rheumatoid synovial fluid" @default.
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- W2088348503 doi "https://doi.org/10.1016/0005-2795(72)90330-3" @default.
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