FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088351636> ?p ?o ?g. }

• W2088351636 endingPage "571" @default.
• W2088351636 startingPage "564" @default.
• W2088351636 abstract "Following transient ischemia of the brain, the coupling between somatosensory activation and the hemodynamic-metabolic response is abolished for a certain period despite the partial recovery of somatosensory evoked responses. To determine whether this disturbance is due to alterations of the stimulus-induced neuronal excitation or to a breakdown of the coupling mechanisms, cortical spreading depression was used as a metabolic stimulus in rats before and after ischemia. Adult rats were subjected to 30 min of global forebrain ischemia and 3-6 h of recirculation. EEG, cortical direct current (DC) potential, and laser-Doppler flow were continuously recorded. Local CBF (LCBF), local CMRglc (LCMRglc), regional tissue contents of ATP, glucose, and lactate, and regional pH were determined by quantitative autoradiography, substrate-induced bioluminescence, and fluorometry. Amplitude and frequency of the DC shifts did not differ between groups. In control animals, spreading depression induced a 77% rise in cortical glucose consumption, a 66% rise in lactate content, and a drop in tissue pH of 0.3 unit. ATP and glucose contents were not depleted. During the passage of DC shifts, transient increases (less than 2 min) in laser-Doppler flow were observed, followed by a post-spreading depression hypoperfusion. A comparable although less expressed pattern of hemodynamic and metabolic changes was observed in the postischemic rats. Although baseline LCMRglc was depressed after ischemia, it was activated 47% during spreading depression. Lactate increased by 26%, pH decreased by 0.3 unit, and ATP and glucose remained unchanged. The extent of the transient increase in laser-Doppler flow did not differ from that of the control group, and a post-spreading depression hypoperfusion was also found.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2088351636 created "2016-06-24" @default.
• W2088351636 creator A5007603481 @default.
• W2088351636 date "1990-07-01" @default.
• W2088351636 modified "2023-10-18" @default.
• W2088351636 title "Metabolic and Hemodynamic Activation of Postischemic Rat Brain by Cortical Spreading Depression" @default.
• W2088351636 cites W1977384695 @default.
• W2088351636 cites W1977873342 @default.
• W2088351636 cites W1980098832 @default.
• W2088351636 cites W1982892406 @default.
• W2088351636 cites W1983226749 @default.
• W2088351636 cites W1995866170 @default.
• W2088351636 cites W2000463622 @default.
• W2088351636 cites W2011835237 @default.
• W2088351636 cites W2015067348 @default.
• W2088351636 cites W2019055116 @default.
• W2088351636 cites W2023826599 @default.
• W2088351636 cites W2024962262 @default.
• W2088351636 cites W2035289565 @default.
• W2088351636 cites W2037181441 @default.
• W2088351636 cites W2038862011 @default.
• W2088351636 cites W2038920673 @default.
• W2088351636 cites W2044963065 @default.
• W2088351636 cites W2060143794 @default.
• W2088351636 cites W2065933576 @default.
• W2088351636 cites W2071939559 @default.
• W2088351636 cites W2075473660 @default.
• W2088351636 cites W2078044800 @default.
• W2088351636 cites W2080949017 @default.
• W2088351636 cites W2085221965 @default.
• W2088351636 cites W2090306035 @default.
• W2088351636 cites W2094428417 @default.
• W2088351636 cites W2117421478 @default.
• W2088351636 cites W2117807828 @default.
• W2088351636 cites W2122131875 @default.
• W2088351636 cites W2130815585 @default.
• W2088351636 cites W2131924839 @default.
• W2088351636 cites W2139426548 @default.
• W2088351636 cites W2146950543 @default.
• W2088351636 cites W2179369946 @default.
• W2088351636 cites W2310907465 @default.
• W2088351636 cites W2403877358 @default.
• W2088351636 doi "https://doi.org/10.1038/jcbfm.1990.99" @default.
• W2088351636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2112136" @default.
• W2088351636 hasPublicationYear "1990" @default.
• W2088351636 type Work @default.
• W2088351636 sameAs 2088351636 @default.
• W2088351636 citedByCount "87" @default.
• W2088351636 countsByYear W20883516362012 @default.
• W2088351636 countsByYear W20883516362013 @default.
• W2088351636 countsByYear W20883516362014 @default.
• W2088351636 countsByYear W20883516362015 @default.
• W2088351636 countsByYear W20883516362016 @default.
• W2088351636 countsByYear W20883516362017 @default.
• W2088351636 countsByYear W20883516362019 @default.
• W2088351636 crossrefType "journal-article" @default.
• W2088351636 hasAuthorship W2088351636A5007603481 @default.
• W2088351636 hasBestOaLocation W20883516361 @default.
• W2088351636 hasConcept C122356138 @default.
• W2088351636 hasConcept C126322002 @default.
• W2088351636 hasConcept C134018914 @default.
• W2088351636 hasConcept C146957229 @default.
• W2088351636 hasConcept C157767197 @default.
• W2088351636 hasConcept C169760540 @default.
• W2088351636 hasConcept C172497186 @default.
• W2088351636 hasConcept C178853913 @default.
• W2088351636 hasConcept C185592680 @default.
• W2088351636 hasConcept C2778541695 @default.
• W2088351636 hasConcept C42219234 @default.
• W2088351636 hasConcept C541997718 @default.
• W2088351636 hasConcept C71924100 @default.
• W2088351636 hasConcept C86803240 @default.
• W2088351636 hasConceptScore W2088351636C122356138 @default.
• W2088351636 hasConceptScore W2088351636C126322002 @default.
• W2088351636 hasConceptScore W2088351636C134018914 @default.
• W2088351636 hasConceptScore W2088351636C146957229 @default.
• W2088351636 hasConceptScore W2088351636C157767197 @default.
• W2088351636 hasConceptScore W2088351636C169760540 @default.
• W2088351636 hasConceptScore W2088351636C172497186 @default.
• W2088351636 hasConceptScore W2088351636C178853913 @default.
• W2088351636 hasConceptScore W2088351636C185592680 @default.
• W2088351636 hasConceptScore W2088351636C2778541695 @default.
• W2088351636 hasConceptScore W2088351636C42219234 @default.
• W2088351636 hasConceptScore W2088351636C541997718 @default.
• W2088351636 hasConceptScore W2088351636C71924100 @default.
• W2088351636 hasConceptScore W2088351636C86803240 @default.
• W2088351636 hasIssue "4" @default.
• W2088351636 hasLocation W20883516361 @default.
• W2088351636 hasLocation W20883516362 @default.
• W2088351636 hasOpenAccess W2088351636 @default.
• W2088351636 hasPrimaryLocation W20883516361 @default.
• W2088351636 hasRelatedWork W143588566 @default.
• W2088351636 hasRelatedWork W1966504330 @default.
• W2088351636 hasRelatedWork W1979139803 @default.
• W2088351636 hasRelatedWork W2034474766 @default.
• W2088351636 hasRelatedWork W2034693740 @default.
• W2088351636 hasRelatedWork W2060637226 @default.
• W2088351636 hasRelatedWork W2244948747 @default.

• next